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Biology and Biochemistry

D-Index
51
Citations
15152
World Ranking
16956
National Ranking
61

Overview

Kong-Peng Lam is affiliated with the Agency for Science, Technology and Research in Singapore. Their research primarily spans multiple areas related to medicine, immunology, and molecular biology, with significant contributions to understanding immune cell functions and interactions.

The scientific output of Kong-Peng Lam covers a range of fields, including:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these broader disciplines, their work focuses on specific subfields, notably:

  • Immunology
  • Molecular Biology
  • Oncology
  • Infectious Diseases
  • Epidemiology

The research topics addressed are:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Immune cells in cancer
  • SARS-CoV-2 and COVID-19 Research
  • Immune Response and Inflammation
  • Immunotherapy and Immune Responses

Examples of recent publications illustrating the scope of their work include:

  • Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer, 2021, Cancer Discovery
  • Glycolysis and Oxidative Phosphorylation Play Critical Roles in Natural Killer Cell Receptor-Mediated Natural Killer Cell Functions, 2020, Frontiers in Immunology
  • Fungal infections: Immune defense, immunotherapies and vaccines, 2023, Advanced Drug Delivery Reviews
  • IL-10 Enhances Human Natural Killer Cell Effector Functions via Metabolic Reprogramming Regulated by mTORC1 Signaling, 2021, Frontiers in Immunology
  • Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes, 2022, Cytotherapy

The venues chosen for publication also reflect active engagement in immunology and related biomedical sciences, with frequent contributions to:

  • Frontiers in Immunology
  • Cytotherapy
  • Pharmaceutics
  • Nature Communications
  • Cell Death and Disease

Kong-Peng Lam collaborates often with several researchers, based on co-authorship frequency, including:

  • Shengli Xu
  • Jia Tong Loh
  • Jianxin Huo
  • Shiyong Neo
  • Biyan Zhang

Best Publications

  • RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

    Yoichi Shinkai;Gary Rathbun;Kong-Peng Lam;Eugene M. Oltz

  • In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

    Kong-Peng Lam;Ralf Kühn;Klaus Rajewsky

  • TACI and BAFF-R mediate isotype switching in B cells.

    Emanuela Castigli;Stephen A Wilson;Sumi Scott;Fatma Dedeoglu

  • Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL.

    Micah J. Benson;Stacey R. Dillon;Emanuela Castigli;Raif S. Geha

  • Memory B-cell persistence is independent of persisting immunizing antigen

    Mitsuo Maruyama;Kong-Peng Lam;Kong-Peng Lam;Klaus Rajewsky

  • Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

    Di Yu;Andy Hee-Meng Tan;Xin Hu;Vicki Athanasopoulos

  • B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses.

    Shengli Xu;Kong-Peng Lam

  • RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.

    A. M. A. Nasirudeen;Hui Hui Wong;Peiling Thien;Shengli Xu

  • B Cell-Specific Deletion of Protein-Tyrosine Phosphatase Shp1 Promotes B-1a Cell Development and Causes Systemic Autoimmunity

    Lily I. Pao;Kong-Peng Lam;Joel M. Henderson;Jeffery L. Kutok

  • ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells

    Yvonne Burmeister;Timo Lischke;Anja C. Dahler;Hans Werner Mages

  • B Cell Antigen Receptor Specificity and Surface Density Together Determine B-1 versus B-2 Cell Development

    Kong-Peng Lam;Klaus Rajewsky

  • Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

    Hweixian Leong Penny;Je Lin Sieow;Giulia Adriani;Wei Hseun Yeap

  • Macrophage polarization to a unique phenotype driven by B cells

    Siew-Cheng Wong;Anne-Laure Puaux;Manesh Chittezhath;Irina Shalova

  • Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.

    Lina E. Tze;Brian R. Schram;Kong Peng Lam;Kristin A. Hogquist

  • Phospholipase Cγ2 Is Critical for Dectin-1-mediated Ca2+ Flux and Cytokine Production in Dendritic Cells

    Shengli Xu;Jianxin Huo;Koon-Guan Lee;Tomohiro Kurosaki

  • B-1 cells: unique origins and functions.

    Alan M. Stall;Sandra M. Wells;Kong Peng Lam

  • A conformational change in cytochrome c of apoptotic and necrotic cells is detected by monoclonal antibody binding and mimicked by association of the native antigen with synthetic phospholipid vesicles

    Ronald Jemmerson;Jiang Liu;Danielle Hausauer;‡ Kong-Peng Lam

  • B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

    Shengli Xu;Joy En-Lin Tan;Esther Poh-Ying Wong;Arunkumar Manickam

  • Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

    Koon-Guan Lee;Shengli Xu;Zi-Han Kang;Jianxin Huo

  • Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population.

    Jimmy Bok Yan So;Ritika Kapoor;Feng Zhu;Calvin Koh

Frequent Co-Authors

Klaus Rajewsky
Klaus Rajewsky Max Delbrück Center for Molecular Medicine
Dong-Yup Lee
Dong-Yup Lee Sungkyunkwan University
Christopher C. Goodnow
Christopher C. Goodnow Garvan Institute of Medical Research
Carola G. Vinuesa
Carola G. Vinuesa Australian National University
Tomohiro Kurosaki
Tomohiro Kurosaki Osaka University
Raif S. Geha
Raif S. Geha Boston Children's Hospital
Lai Guan Ng
Lai Guan Ng Westlake University
Subhra K. Biswas
Subhra K. Biswas Agency for Science, Technology and Research
Sven Pettersson
Sven Pettersson Karolinska Institute
Richard A. Kroczek
Richard A. Kroczek Robert Koch Institute

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