D-Index & Metrics Best Publications
K. H. Andy Choo

K. H. Andy Choo

Royal Children's Hospital
Australia

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Chromosome

K. H. Andy Choo mainly focuses on Centromere, Genetics, Neocentromere, Chromatin and Centromere Protein A. The study incorporates disciplines such as RNA, Molecular biology, Cell biology, Transcription and Kinetochore in addition to Centromere. His work deals with themes such as Metaphase, INCENP and Embryogenesis, which intersect with Molecular biology.

As a member of one scientific family, he mostly works in the field of Neocentromere, focusing on Marker chromosome and, on occasion, Genome, DNA sequencing and Centromere protein B. His studies examine the connections between Chromatin and genetics, as well as such issues in Aurora B kinase, with regards to Condensin, Transcription factor and Transcription factor II D. His Centromere Protein A research is within the category of Chromosome.

His most cited work include:

  • Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype (484 citations)
  • Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution (293 citations)
  • A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA (288 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Genetics, Centromere, Neocentromere, Molecular biology and Chromosome. The concepts of his Centromere study are interwoven with issues in Metaphase, Evolutionary biology, Mitosis, Chromatin and Kinetochore. His studies deal with areas such as Computational biology and Aurora B kinase as well as Chromatin.

His work carried out in the field of Neocentromere brings together such families of science as Histone H3, Centromere Protein A, Nucleosome and Marker chromosome. His study in Centromere Protein A is interdisciplinary in nature, drawing from both Heterochromatin protein 1 and DNA-binding protein. His Molecular biology research incorporates themes from INCENP, In situ hybridization, BUB3, Gene and Centromere protein B.

He most often published in these fields:

  • Genetics (68.83%)
  • Centromere (59.74%)
  • Neocentromere (42.86%)

What were the highlights of his more recent work (between 2011-2014)?

  • Centromere (59.74%)
  • Genetics (68.83%)
  • Mitosis (22.08%)

In recent papers he was focusing on the following fields of study:

Centromere, Genetics, Mitosis, Histone and Chromatin are his primary areas of study. Centromere and General transcription factor are two areas of study in which K. H. Andy Choo engages in interdisciplinary work. His research in the fields of Neocentromere, Gene duplication and Chromosome aberration overlaps with other disciplines such as Gene mutation and Chromothripsis.

His Mitosis research is multidisciplinary, incorporating perspectives in Phenotype, DNA, Green fluorescent protein, Meiotic drive and Centromere protein B. His Histone research integrates issues from Satellite DNA, Chromosome, Eukaryotic chromosome fine structure, Human genome and Pericentric heterochromatin. The various areas that he examines in his Chromatin study include Death-associated protein 6, Transcription factor II D and Aurora B kinase, Kinetochore.

Between 2011 and 2014, his most popular works were:

  • Active transcription and essential role of RNA polymerase II at the centromere during mitosis (177 citations)
  • Contrasting roles of condensin I and condensin II in mitotic chromosome formation (124 citations)
  • The architecture and evolution of cancer neochromosomes. (113 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Chromosome

K. H. Andy Choo focuses on Aurora B kinase, Chromatin, Centromere, Genetics and Transcription factor. His Aurora B kinase study integrates concerns from other disciplines, such as Mitosis, Cell biology, Prophase, Anaphase and Condensin. His Condensin complex research extends to the thematically linked field of Chromatin.

His Centromere study focuses on Neocentromere in particular. His research on Genetics frequently links to adjacent areas such as Evolutionary biology. His Transcription factor research includes themes of Molecular biology, Transcription factor II D and Kinetochore.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

Anthony G. Uren;Lee Lee Wong;Miha Pakusch;Kerry J. Fowler.
Current Biology (2000)

709 Citations

Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

Owen J. Marshall;Anderly C. Chueh;Lee H. Wong;K.H. Andy Choo.
American Journal of Human Genetics (2008)

358 Citations

A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA

Desiree Du Sart;Michael R. Cancilla;Elizabeth Earle;Jen I. Mao.
Nature Genetics (1997)

353 Citations

Neocentromeres: role in human disease, evolution, and centromere study.

David J. Amor;K.H. Andy Choo.
American Journal of Human Genetics (2002)

301 Citations

Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere.

Lee H. Wong;Kate H. Brettingham-Moore;Lyn Chan;Julie M. Quach.
Genome Research (2007)

301 Citations

Domain organization at the centromere and neocentromere.

K.H.Andy Choo.
Developmental Cell (2001)

251 Citations

Human centromere repositioning “in progress”

David J. Amor;Karen Bentley;Jacinta Ryan;Jo Perry.
Proceedings of the National Academy of Sciences of the United States of America (2004)

246 Citations

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

F. Lyn Chan;Owen J. Marshall;Richard Saffery;Bo Won Kim.
Proceedings of the National Academy of Sciences of the United States of America (2012)

238 Citations

Building the centromere: from foundation proteins to 3D organization

David J. Amor;Paul Kalitsis;Huseyin Sumer;K.H. Andy Choo.
Trends in Cell Biology (2004)

226 Citations

Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins.

Richard Saffery;Danielle V. Irvine;Belinda Griffiths;Paul Kalitsis.
Human Molecular Genetics (2000)

198 Citations

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