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Junya Toguchida

Junya Toguchida

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
13657
World Ranking
8794
National Ranking
594

Overview

Junya Toguchida is affiliated with Kyoto University in Japan and conducts research primarily within the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work encompasses a broad range of topics, with a notable focus on molecular and cellular mechanisms related to disease and regenerative medicine.

The main topics covered by Toguchida's research include:

  • Sarcoma Diagnosis and Treatment
  • Pluripotent Stem Cells Research
  • Heterotopic Ossification and Related Conditions
  • Osteoarthritis Treatment and Mechanisms
  • Renal and related cancers
  • Ubiquitin and proteasome pathways
  • Mesenchymal stem cell research

Toguchida's subfields of study further highlight their multidisciplinary approach:

  • Molecular Biology
  • Rheumatology
  • Pulmonary and Respiratory Medicine
  • Surgery
  • Genetics

The research output includes publications in several notable venues, showing a focus on emerging biomedical engineering and clinical science fields. Frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Biomedical Engineering
  • Orphanet Journal of Rare Diseases
  • Cancer Science
  • Science

Key recent papers authored or co-authored by Toguchida cover diverse subjects ranging from developmental biology to tissue engineering, reflecting research on stem cells and biomechanics. Notable papers include:

  • Species-specific segmentation clock periods are due to differential biochemical reaction speeds, 2020, Science
  • Recapitulating the human segmentation clock with pluripotent stem cells, 2020, Nature
  • Bio-3D printing iPSC-derived human chondrocytes for articular cartilage regeneration, 2021, Biofabrication
  • Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells, 2021, Nature Biomedical Engineering
  • Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells, 2020, Stem Cells Translational Medicine

Toguchida collaborates frequently with a consistent group of co-authors, suggesting ongoing collaborative research efforts. These frequent co-authors include:

  • Shuichi Matsuda
  • Megumi Nishio
  • Sanae Nagata
  • Shunsuke Kawai
  • Hiroyuki Yoshitomi

Best Publications

  • Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

    T Sakai;J Toguchida;N Ohtani;D W Yandell

  • Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells.

    Takeshi Okamoto;Tomoki Aoyama;Tomitaka Nakayama;Takeharu Nakamata

  • Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.

    Junya Toguchida;Toshikazu Yamaguchi;Bruce Ritchie;Roberta L. Beauchamp

  • Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma

    Junya Toguchida;Toshikazu Yamaguchi;Siri H. Dayton;Roberta L. Beaughamp

  • Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

    Kyosuke Hino;Makoto Ikeya;Kazuhiko Horigome;Yoshihisa Matsumoto

  • Mutation Spectrum of the Retinoblastoma Gene in Osteosarcomas

    Bun-ichiro Wadayama;Junya Toguchida;Takashi Shimizu;Kanji Ishizaki

  • Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

    Masatoshi Kajiwara;Takashi Aoi;Keisuke Okita;Ryosuke Takahashi

  • Frequency and structure of p53 rearrangements in human osteosarcoma

    C. W. Miller;A. Aslo;C. Tsay;D. Slamon

  • Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion.

    Kotaro R. Shibata;Tomoki Aoyama;Yasuko Shima;Kenichi Fukiage

  • Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.

    Junya Toguchida;Kanji Ishizaki;Masao S. Sasaki;Mituo Ikenaga

  • Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma.

    Junya Toguchida;Kanji Ishizaki;Masao S. Sasaki;Yusuke Nakamura

  • Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL).

    Isao Nakamura;Shiro Ikegawa;Akihiko Okawa;Shin'ya Okuda

  • Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q.

    Toshikazu Yamaguchi;Junya Toguchida;Takao Yamamuro;Yoshihiko Kotoura

  • Complete genomic sequence of the human retinoblastoma susceptibility gene

    Junya Toguchida;Terri L. McGee;Jennifer C. Paterson;Janine R. Eagle

  • Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media

    Makoto Fukuta;Yoshinori Nakai;Kosuke Kirino;Masato Nakagawa

  • Role and Mutational Heterogeneity of the p53 Gene in Hepatocellular Carcinoma

    Naoshi Nishida;Yoshihiro Fukuda;Hiroyuki Kokuryu;Junya Toguchida

  • Loss of 17p, Mutation of the p53 Gene, and Overexpression of p53 Protein in Esophageal Squamous Cell Carcinomas

    Takashi Wagata;Ichio Shibagaki;Masayuki Imamura;Yutaka Shimada

  • Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas

    Satoshi Nagayama;Chikako Fukukawa;Toyomasa Katagiri;Takeshi Okamoto

  • Species-specific segmentation clock periods are due to differential biochemical reaction speeds

    Mitsuhiro Matsuda;Hanako Hayashi;Jordi Garcia-Ojalvo;Kumiko Yoshioka-Kobayashi

  • Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints

    P. Kumar;M. Oka;Junya Toguchida;M. Kobayashi

Frequent Co-Authors

Takashi Nakamura
Takashi Nakamura Kyoto University
Yusuke Nakamura
Yusuke Nakamura National Institutes of Biomedical Innovation, Health and Nutrition
Toyomasa Katagiri
Toyomasa Katagiri University of Tokushima
Takuya Yamamoto
Takuya Yamamoto Kyoto University
Toshio Heike
Toshio Heike Kyoto University
David W. Yandell
David W. Yandell Harvard University
Yasuhiro Yamada
Yasuhiro Yamada University of Tokyo
Takashi Shimizu
Takashi Shimizu Nagoya University
Hideki Yoshikawa
Hideki Yoshikawa Osaka University

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