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Jean-Philippe Loeffler

Jean-Philippe Loeffler

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
14970
World Ranking
7498
National Ranking
248

Overview

Jean-Philippe Loeffler is affiliated with the University of Strasbourg in France. Their research primarily focuses on medical sciences, with a specialization in neurology, genetics, physiology, molecular biology, and cellular and molecular neuroscience. Their work emphasizes amyotrophic lateral sclerosis (ALS) research, Parkinson's disease mechanisms and treatments, neurogenetic and muscular disorders, lysosomal storage disorders, muscle physiology and disorders, genetic neurodegenerative diseases, and mitochondrial function and pathology.

The most frequent publication venues for Loeffler include Brain Communications, bioRxiv (Cold Spring Harbor Laboratory), Seminars in Cell and Developmental Biology, British Journal of Pharmacology, and European Journal of Pharmacology.

Among their recent papers are:

  • "Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis," 2020, Brain Communications
  • "Sphingolipids metabolism alteration in the central nervous system: Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases," 2020, Seminars in Cell and Developmental Biology
  • "Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93Amice," 2021, British Journal of Pharmacology
  • "Drug repositioning in neurodegeneration: An overview of the use of ambroxol in neurodegenerative diseases," 2020, European Journal of Pharmacology
  • "Alteration of the Neuromuscular Junction and Modifications of Muscle Metabolism in Response to Neuron-Restricted Expression of the CHMP2Bintron5 Mutant in a Mouse Model of ALS-FTD Syndrome," 2022, Biomolecules

Loeffler collaborates frequently with several coauthors, including Shyuan T. Ngo, Frédérique René, Frederik J. Steyn, Alberto Ferri, and Cristiana Valle.

Best Publications

  • Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA

    Jean-Paul Behr;Barbara Demeneix;Jean-Philippe Loeffler;Jose Perez-Mutul

  • Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model.

    Luc Dupuis;Hugues Oudart;Frédérique René;Jose-Luis Gonzalez de Aguilar

  • Energy metabolism in amyotrophic lateral sclerosis.

    Luc Dupuis;Luc Dupuis;Pierre-François Pradat;Albert C Ludolph;Jean-Philippe Loeffler;Jean-Philippe Loeffler

  • Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration.

    Caroline Rouaux;Natasa Jokic;Corinne Mbebi;Stephanie Boutillier

  • Lipopolyamines, their preparation and their use

    Jean-Paul Behr;Jean-Philippe Loeffler

  • Guidelines for preclinical animal research in ALS/MND: A consensus meeting.

    Albert C. Ludolph;Caterina Bendotti;Eran Blaugrund;Adriano Chio

  • Sodium Valproate Exerts Neuroprotective Effects In Vivo through CREB-Binding Protein-Dependent Mechanisms But Does Not Improve Survival in an Amyotrophic Lateral Sclerosis Mouse Model

    Caroline Rouaux;Irina Panteleeva;Frédérique René;Jose-Luis Gonzalez de Aguilar

  • Spatial Memory Consolidation is Associated with Induction of Several Lysine-Acetyltransferase (Histone Acetyltransferase) Expression Levels and H2B/H4 Acetylation-Dependent Transcriptional Events in the Rat Hippocampus

    Olivier Bousiges;Anne Pereira de Vasconcelos;Romain Neidl;Romain Neidl;Brigitte Cosquer

  • A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP

    Xiangjun Meng;Mili L. Leyva;Marjorie Jenny;Isabelle Gross

  • Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models

    Luc Dupuis;Jean-Philippe Loeffler;Jean-Philippe Loeffler

  • Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons

    Luc Dupuis;Luc Dupuis;Jose-Luis Gonzalez de Aguilar;Jose-Luis Gonzalez de Aguilar;Andoni Echaniz-Laguna;Andoni Echaniz-Laguna;Judith Eschbach;Judith Eschbach

  • A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

    Lavinia Palamiuc;Lavinia Palamiuc;Anna Schlagowski;Shyuan T Ngo;Aurelia Vernay;Aurelia Vernay

  • Nogo-A, -B, and -C Are Found on the Cell Surface and Interact Together in Many Different Cell Types

    Dana A. Dodd;Barbara Niederoest;Stefan Bloechlinger;Luc Dupuis

  • The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis

    Jean-Philippe Loeffler;Jean-Philippe Loeffler;Gina Picchiarelli;Gina Picchiarelli;Luc Dupuis;Luc Dupuis;Jose-Luis Gonzalez De Aguilar;Jose-Luis Gonzalez De Aguilar

  • Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis.

    Luc Dupuis;Jose-Luis Gonzalez de Aguilar;Franck di Scala;Frédérique Rene

  • Impaired glucose tolerance in patients with amyotrophic lateral sclerosis.

    Pierre-Francois Pradat;Gaelle Bruneteau;Paul H Gordon;Luc Dupuis

  • Ruthenium (II)-Derived Organometallic Compounds Induce Cytostatic and Cytotoxic Effects on Mammalian Cancer Cell Lines through p53-Dependent and p53-Independent Mechanisms

    Christian Gaiddon;Pierre Jeannequin;Pierre Bischoff;Michel Pfeffer

  • The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model

    Natasa Jokic;Jose-Luis Gonzalez de Aguilar;Leda Dimou;Shuo Lin

  • Gene transfer into primary and established mammalian cell lines with lipopolyamine-coated DNA

    Jean-Philippe Loeffler;Jean-Paul Behr

  • Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders

    Caroline Rouaux;Jean-Philippe Loeffler;Anne-Laurence Boutillier

Frequent Co-Authors

Jean-Paul Behr
Jean-Paul Behr Centre national de la recherche scientifique, CNRS
Albert C. Ludolph
Albert C. Ludolph University of Ulm
Claude B. Sirlin
Claude B. Sirlin University of California, San Diego
Barbara A. Demeneix
Barbara A. Demeneix Centre national de la recherche scientifique, CNRS
Michael Spedding
Michael Spedding DuPont (United States)
André Delacourte
André Delacourte University of Lille
Luc Buée
Luc Buée University of Lille
Bradley T. Hyman
Bradley T. Hyman Harvard University
Rita Guerreiro
Rita Guerreiro Van Andel Institute
Jose Bras
Jose Bras Van Andel Institute

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