World's Best Scientists 2026 revealed!

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Medicine

D-Index
101
Citations
45569
World Ranking
7866
National Ranking
240

Overview

Jean Chastre is affiliated with Sorbonne University in France and has contributed extensively to the field of medicine with a focus on epidemiology, critical care, infectious diseases, pulmonary and respiratory medicine, and applied microbiology and biotechnology. Their work predominantly addresses clinical challenges related to respiratory infections and intensive care treatment protocols.

Their research covers a range of topics, including:

  • Nosocomial infections in ICU
  • Pneumonia and respiratory infections
  • Respiratory support and mechanisms
  • Antibiotic use and resistance
  • Sepsis diagnosis and treatment
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Tuberculosis research and epidemiology

Jean Chastre has published numerous papers in highly regarded medical journals. Notable recent publications include:

  • "Treatment of Community-Acquired Pneumonia in Immunocompromised Adults" (2020, CHEST Journal)
  • "Ventilator-associated pneumonia in patients with SARS-CoV-2-associated acute respiratory distress syndrome requiring ECMO: a retrospective cohort study" (2020, Annals of Intensive Care)
  • "The challenge of ventilator-associated pneumonia diagnosis in COVID-19 patients" (2020, Critical Care)
  • "Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM" (2020, Annals of the American Thoracic Society)
  • "Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial" (2021, The Lancet Infectious Diseases)

Their collaborations include frequent co-authors such as Charles-Édouard Luyt, Grant Waterer, Tobias Welte, Michael S. Niederman, and Antoní Torres. These partnerships reflect a network of scholars working on overlapping topics in critical care and infectious diseases.

Jean Chastre has published several papers in key journals related to their fields, including Open Forum Infectious Diseases, Critical Care, Annals of Intensive Care, Annals of the American Thoracic Society, and The Lancet Infectious Diseases. These venues highlight the medical and clinical nature of their research output.

The scientist's body of work is rooted in advancing understanding and clinical management of infections in intensive care contexts, particularly ventilator-associated pneumonia and community-acquired pneumonia in vulnerable populations. Their research also touches on antimicrobial stewardship and emerging challenges posed by viral respiratory syndromes such as COVID-19.

Best Publications

  • Ventilator-associated pneumonia.

    Jean Chastre;Jean-Yves Fagon

  • Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial.

    Jean Chastre;Michel Wolff;Jean-Yves Fagon;Sylvie Chevret

  • Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay

    Jean-Yves Fagon;Jean Chastre;Allan J. Hance;Philippe Montravers

  • Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial.

    Lila Bouadma;Charles-Edouard Luyt;Florence Tubach;Christophe Cracco

  • International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia

    Antoni Torres;Michael S Niederman;Jean Chastre;Santiago Ewig

  • Ventilator-associated pneumonia caused by potentially drug-resistant bacteria

    Jean-Louis Trouillet;Jean Chastre;Albert Vuagnat;Marie-Laure Joly-Guillou

  • Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques.

    Jean-Yves Fagon;Jean Chastre;Yves Domart;Jean-Louis Trouillet

  • Tidal Volume Reduction for Prevention of Ventilator-induced Lung Injury in Acute Respiratory Distress Syndrome

    Brochard L;Roudot-Thoraval F;Roupie E;Delclaux C

  • Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock*

    Alain Combes;Pascal Leprince;Charles-Edouard Luyt;Nicolas Bonnet

  • Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study.

    Richard G. Wunderink;Michael S. Niederman;Marin H. Kollef;Andrew F. Shorr

  • Nosocomial Pneumonia and Mortality Among Patients in Intensive Care Units

    Jean-Yves Fagon;Jean Chastre;Albert Vuagnat;Jean-Louis Trouillet

  • Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006.

    Massimo Antonelli;Mitchell Levy;Peter J. D. Andrews;Jean Chastre

  • Ventilator-associated pneumonia

    Jean Chastre;Jean-Yves Fagon;Groupe Hospitalier Pitié-Salpêtrière

  • Detection of Nosocomial Lung Infection in Ventilated Patients: Use of a Protected Specimen Brush and Quantitative Culture Techniques in 147 Patients

    Jean-Yves Fagon;Jean Chastre;Allan J. Hance;Marguerite Guiguet

  • The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome

    Matthieu Schmidt;Elie Zogheib;Hadrien Rozé;Xavier Repesse

  • Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis

    Philipp Schuetz;Yannick Wirz;Ramon Sager;Mirjam Christ-Crain;Mirjam Christ-Crain

  • Evaluation of bronchoscopic techniques for the diagnosis of nosocomial pneumonia.

    J Chastre;J Y Fagon;M Bornet-Lecso;S Calvat

  • Morbidity, mortality, and quality-of-life outcomes of patients requiring ≥14 days of mechanical ventilation

    Alain Combes;Marie-Alyette Costa;Jean-Louis Trouillet;Jérôme Baudot

  • Characterization of intensive care unit patients using a model based on the presence or absence of organ dysfunctions and/or infection: The ODIN model

    J. Y. Fagon;J. Chastre;A. Novara;P. Medioni

  • Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections (Review)

    Schuetz P;Müller B;Christ-Crain M;Stolz D

Frequent Co-Authors

Charles-Edouard Luyt
Charles-Edouard Luyt Assistance Publique – Hôpitaux de Paris
Pascal Leprince
Pascal Leprince Université Paris Cité
Antoni Torres
Antoni Torres University of Barcelona
Jordi Rello
Jordi Rello Instituto de Salud Carlos III
Tobias Welte
Tobias Welte University of Hannover
Matthieu Schmidt
Matthieu Schmidt Université Paris Cité
Marin H. Kollef
Marin H. Kollef Washington University in St. Louis
Michael S. Niederman
Michael S. Niederman Cornell University
Michel Wolff
Michel Wolff Université Paris Cité
Matteo Bassetti
Matteo Bassetti University of Genoa

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