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Biology and Biochemistry

D-Index
57
Citations
19600
World Ranking
13548
National Ranking
1058

Overview

James R. Brown is affiliated with GlaxoSmithKline in the United Kingdom. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology as well as Medicine, with a strong focus on Molecular Biology, Epidemiology, and Pulmonary and Respiratory Medicine, among others.

Brown's work addresses a variety of topics, particularly in relation to microbiota and health, chronic respiratory conditions, infectious diseases, and bioinformatics. Key areas of focus include:

  • Gut microbiota and health
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Urinary Tract Infections Management
  • Machine Learning in Bioinformatics
  • Metabolomics and Mass Spectrometry Studies
  • Pediatric health and respiratory diseases
  • Genomics and Phylogenetic Studies

Some of the recent scientific papers authored or co-authored by Brown include:

  • PICRUSt2 for prediction of metagenome functions, 2020, Nature Biotechnology
  • Inflammatory Endotype-associated Airway Microbiome in Chronic Obstructive Pulmonary Disease Clinical Stability and Exacerbations: A Multicohort Longitudinal Analysis, 2020, American Journal of Respiratory and Critical Care Medicine
  • The sputum microbiome is distinct between COPD and health, independent of smoking history, 2020, Respiratory Research
  • Multi-omic meta-analysis identifies functional signatures of airway microbiome in chronic obstructive pulmonary disease, 2020, The ISME Journal
  • Expanding the drug discovery space with predicted metabolite-target interactions, 2021, Communications Biology

The scientist frequently collaborates with other researchers, including Andrea Nuzzo, Bahrad A. Sokhansanj, Gail Rosen, Zhang Wang, and Ruth Tal-Singer.

Brown's work has been published mainly in venues such as Communications Biology, BMC Microbiology, arXiv (Cornell University), Nature Biotechnology, and the American Journal of Respiratory and Critical Care Medicine. The contributions in these journals reflect a breadth of research output with topics covering microbiology, respiratory medicine, and bioinformatics applications.

Best Publications

  • PICRUSt2 for prediction of metagenome functions.

    Gavin M. Douglas;Vincent J. Maffei;Jesse R. Zaneveld;Svetlana N. Yurgel

  • Thousands of chemical starting points for antimalarial lead identification

    Francisco-Javier Gamo;Laura M. Sanz;Jaume Vidal;Cristina de Cozar

  • Archaea and the prokaryote-to-eukaryote transition.

    J R Brown;W F Doolittle

  • Root of the universal tree of life based on ancient aminoacyl-tRNA synthetase gene duplications.

    J R Brown;W F Doolittle

  • Universal trees based on large combined protein sequence data sets

    James R. Brown;Christophe J. Douady;Michael J. Italia;William E. Marshall

  • Lung microbiome dynamics in COPD exacerbations

    Zhang Wang;Mona Bafadhel;Koirobi Haldar;Koirobi Haldar;Aaron Spivak

  • A genomic analysis of two‐component signal transduction in Streptococcus pneumoniae

    John P. Throup;Kristin K. Koretke;Alexander P. Bryant;Karen A. Ingraham

  • Evolution of Two-Component Signal Transduction

    Kristin K. Koretke;Andrei N. Lupas;Patrick V. Warren;Martin Rosenberg

  • Ancient horizontal gene transfer.

    James R. Brown

  • Length heteroplasmy of sturgeon mitochondrial DNA: an illegitimate elongation model.

    N E Buroker;J R Brown;T A Gilbert;P J O'Hara

  • Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci

    E. Imogen Wilding;James R. Brown;Alexander P. Bryant;Alison F. Chalker

  • PICRUSt2: An improved and customizable approach for metagenome inference

    Gavin M. Douglas;Vincent J. Maffei;Jesse Zaneveld;Svetlana N. Yurgel

  • Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus.

    Antonella Napolitano;Sam Miller;Andrew W. Nicholls;David Baker

  • PICRUSt2: An improved and extensible approach for metagenome inference

    Gavin M. Douglas;Vincent J. Maffei;Jesse Zaneveld;Svetlana N. Yurgel

  • Genomic sequence of hyperthermophile, Pyrococcus furiosus: implications for physiology and enzymology.

    Frank T Robb;Dennis L Maeder;James R Brown;Jocelyne DiRuggiero

  • Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations

    David Mayhew;Nathalie Devos;Christophe Lambert;James R Brown

  • Intraspecific DNA sequence variation of the mitochondrial control region of white sturgeon (Acipenser transmontanus).

    James R. Brown;Andrew T. Beckenbach;Michael J. Smith

  • New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

    Imanol Peña;M. Pilar Manzano;Juan Cantizani;Albane Kessler

  • Phylogenetic analyses do not support horizontal gene transfers from bacteria to vertebrates

    Michael J. Stanhope;Andrei Lupas;Michael J. Italia;Kristin K. Koretke

  • Tempo, mode, the progenote, and the universal root.

    W F Doolittle;J R Brown

Frequent Co-Authors

Michael J. Stanhope
Michael J. Stanhope Cornell University
Ruth Tal-Singer
Ruth Tal-Singer GlaxoSmithKline (United Kingdom)
Christopher E. Brightling
Christopher E. Brightling University of Leicester
Andrei N. Lupas
Andrei N. Lupas Max Planck Society
Dave Singh
Dave Singh University of Manchester
Frank T. Robb
Frank T. Robb University of Maryland, Baltimore
Hans Neurath
Hans Neurath University of Washington
Curtis Huttenhower
Curtis Huttenhower Harvard University
Martin Rosenberg
Martin Rosenberg GlaxoSmithKline (United Kingdom)
Jadwiga A. Wedzicha
Jadwiga A. Wedzicha Imperial College London

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