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Hiroaki Nagano

Hiroaki Nagano

D-Index & Metrics

Medicine

D-Index
86
Citations
28384
World Ranking
14086
National Ranking
422

Overview

Hiroaki Nagano is affiliated with Osaka University in Japan and has contributed extensively to medical research, particularly in the fields of oncology, surgery, and hepatology. Their work focuses largely on pancreatic and hepatic oncology, with specific attention to cholangiocarcinoma, gallbladder cancer, hepatocellular carcinoma, and related liver diseases.

The scientist's publications demonstrate a consistent engagement with cancer research and treatment methodologies, including studies on colorectal and gastric cancers. Recent notable papers include:

  • Randomized phase III study of gemcitabine, cisplatin plus S-1 versus gemcitabine, cisplatin for advanced biliary tract cancer (KHBO1401-MITSUBA), 2022, Journal of Hepato-Biliary-Pancreatic Sciences
  • Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial, 2023, The Lancet
  • Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model, 2020, Biomaterials
  • The impact of COVID-19 on surgical procedures in Japan: analysis of data from the National Clinical Database, 2021, Surgery Today
  • Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids, 2021, Biomedicine & Pharmacotherapy

Frequent collaborators include Yoshitaro Shindo, Hiroto Matsui, Tatsuya Ioka, Ryouichi Tsunedomi, and Yukio Tokumitsu, reflecting longstanding research partnerships.

Hiroaki Nagano has published multiple articles in well-known academic venues, with the most frequent publication outlets being:

  • Annals of Gastroenterological Surgery
  • Journal of Hepato-Biliary-Pancreatic Sciences
  • Surgery Today
  • Anticancer Research
  • Scientific Reports

The primary field of study for Nagano is medicine, with 352 publications. The major subfields contributing to their research output include oncology, surgery, pulmonary and respiratory medicine, epidemiology, and hepatology.

The main research topics covered involve:

  • Pancreatic and Hepatic Oncology Research
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Gallbladder and Bile Duct Disorders
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Colorectal Cancer Treatments and Studies
  • Gastric Cancer Management and Outcomes
  • Liver Disease Diagnosis and Treatment

Best Publications

  • International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

    Franck Pagès;Bernhard Mlecnik;Florence Marliot;Gabriela Bindea;Gabriela Bindea;Gabriela Bindea

  • Reprogramming of mouse and human cells to pluripotency using mature microRNAs.

    Norikatsu Miyoshi;Hideshi Ishii;Hideshi Ishii;Hiroaki Nagano;Naotsugu Haraguchi

  • CD13 is a therapeutic target in human liver cancer stem cells

    Naotsugu Haraguchi;Hideshi Ishii;Hideshi Ishii;Koshi Mimori;Fumiaki Tanaka

  • Clinical practice guidelines for hepatocellular carcinoma: The Japan Society of Hepatology 2017 (4th JSH-HCC guidelines) 2019 update.

    Norihiro Kokudo;Nobuyuki Takemura;Kiyoshi Hasegawa;Tadatoshi Takayama

  • The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

    Satoshi Shimizu;Tetsuo Takehara;Hayato Hikita;Takahiro Kodama

  • Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma.

    Yoshito Tomimaru;Hidetoshi Eguchi;Hiroaki Nagano;Hiroshi Wada

  • Defined factors induce reprogramming of gastrointestinal cancer cells

    Norikatsu Miyoshi;Hideshi Ishii;Hideshi Ishii;Ken Ichi Nagai;Hiromitsu Hoshino

  • Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation.

    Takahiro Tsuboyama;Hiromitsu Onishi;Tonsok Kim;Hirofumi Akita

  • Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow

    Sachiyo Kogita;Yasuharu Imai;Masahiro Okada;Tonsok Kim

  • Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.

    Satoshi Tanaka;Hayato Hikita;Tomohide Tatsumi;Ryotaro Sakamori

  • Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.

    Shinji Yamamoto;Yasuhiko Tomita;Yoshihiko Hoshida;Takaya Morooka

  • Sorafenib plus low-dose cisplatin and fluorouracil hepatic arterial infusion chemotherapy versus sorafenib alone in patients with advanced hepatocellular carcinoma (SILIUS): a randomised, open label, phase 3 trial.

    Masatoshi Kudo;Kazuomi Ueshima;Osamu Yokosuka;Sadahisa Ogasawara

  • Combined intraarterial 5‐fluorouracil and subcutaneous interferon‐α therapy for advanced hepatocellular carcinoma with tumor thrombi in the major portal branches

    Masato Sakon;Hiroaki Nagano;Keizo Dono;Shoji Nakamori

  • Patterns and clinicopathologic features of extrahepatic recurrence of hepatocellular carcinoma after curative resection.

    Yubo Yang;Hiroaki Nagano;Hideo Ota;Osakuni Morimoto

  • Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma.

    Motoi Kondo;Hirofumi Yamamoto;Hiroaki Nagano;Jiro Okami

  • Overexpression of Cyclooxygenase-2 in Carcinoma of the Pancreas

    Jiro Okami;Hirofumi Yamamoto;Yoshiyuki Fujiwara;Masaki Tsujie

  • Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer

    Shin Nakahira;Shoji Nakamori;Masanori Tsujie;Yuji Takahashi

  • Superparamagnetic iron oxide-enhanced magnetic resonance images of hepatocellular carcinoma : Correlation with histological grading

    Yasuharu Imai;Takamichi Murakami;Shigeyuki Yoshida;Masahiro Nishikawa

  • MicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells.

    Y Tomimaru;H Eguchi;H Nagano;H Wada

  • Treatment of node-positive endometrial cancer with complete node dissection, chemotherapy and radiation therapy

    T Onda;H Yoshikawa;K Mizutani;M Mishima

Frequent Co-Authors

Hidetoshi Eguchi
Hidetoshi Eguchi Osaka University
Masaki Mori
Masaki Mori Kyushu University
Yuichiro Doki
Yuichiro Doki Osaka University
Morito Monden
Morito Monden Osaka University
Shoji Nakamori
Shoji Nakamori Osaka University
Hirofumi Yamamoto
Hirofumi Yamamoto Osaka University
Hironobu Nakamura
Hironobu Nakamura Osaka University
Takamichi Murakami
Takamichi Murakami Kobe University
Eiji Miyoshi
Eiji Miyoshi Osaka University
Hiroki Yamaue
Hiroki Yamaue Wakayama Medical University

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