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Biology and Biochemistry

D-Index
43
Citations
9684
World Ranking
19361
National Ranking
1498

Overview

David S. Leake is affiliated with the University of Reading in the United Kingdom. Their research spans multiple fields including Medicine and Biochemistry, Genetics and Molecular Biology, with primary focuses in subfields such as Biochemistry, Immunology, Molecular Biology, Surgery, and Clinical Biochemistry.

Their published work covers a variety of scientific topics, notably:

  • Antioxidant Activity and Oxidative Stress
  • Advanced Glycation End Products research
  • Drug Transport and Resistance Mechanisms
  • Biomedical Research and Pathophysiology
  • Peroxisome Proliferator-Activated Receptors
  • Cholesterol and Lipid Metabolism
  • Lipoproteins and Cardiovascular Health

David S. Leake has contributed to several scientific papers recently, including:

  • "Cysteamine Decreases Low-Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low-Density Lipoprotein Receptor-Deficient Mice" (2021), published in the Journal of the American Heart Association
  • "Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment" (2021), published in Frontiers in Immunology
  • "Vitamins E and C do not effectively inhibit low density lipoprotein oxidation by ferritin at lysosomal pH" (2021), published in Free Radical Research
  • "Effect of vitamin E on low density lipoprotein oxidation at lysosomal pH" (2020), published in Free Radical Research
  • "Effects of lysosomal low-density lipoprotein oxidation by ferritin on macrophage function" (2022), published in Free Radical Research

Their frequent co-authors include:

  • Tom Houben
  • Tulasi Yadati
  • Ronit Shiri-Sverdlov
  • Oluwatosin O. Ojo
  • Hadeel K. M. Alboaklah

In terms of publication venues, David S. Leake most often publishes in:

  • Free Radical Research
  • Journal of the American Heart Association
  • Frontiers in Immunology
  • Biomedicines
  • Innate Immunity

Best Publications

  • Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids

    Urs P. Steinbrecher;Sampath Parthasarathy;David S. Leake;Joseph L. Witztum

  • Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages.

    Catherine V. de Whalley;Sara M. Rankin;J.Robin S. Hoult;Wendy Jessup;Wendy Jessup

  • Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor.

    Colin H. Macphee;Kitty E. Moores;Helen F. Boyd;Dash Dhanak

  • Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages Activation by Oxidatively Modified LDL and 4-Hydroxynonenal

    Tetsuro Ishii;Ken Itoh;Emilio Ruiz;David S. Leake

  • α-tocopherol consumption during low-density-lipoprotein oxidation

    W Jessup;S M Rankin;C V De Whalley;J R S Hoult

  • In Vitro Antioxidant Activity of Coffee Compounds and Their Metabolites

    José Ángel Gómez-Ruiz;David S. Leake;Jennifer M. Ames

  • The oxidative modification of low-density lipoproteins by macrophages.

    D S Leake;S M Rankin

  • Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men

    Sabine Tricon;Graham C Burdge;Emma L Jones;Jennifer J Russell

  • Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid.

    Rebecca A. Patterson;Elizabeth T.M. Horsley;David S. Leake

  • Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?

    Charles J.J Alderman;Peter R Bunyard;Benjamin M Chain;John C Foreman

  • Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions

    David S. Leake

  • Vitamin C Protects Human Vascular Smooth Muscle Cells Against Apoptosis Induced by Moderately Oxidized LDL Containing High Levels of Lipid Hydroperoxides

    Richard C. M. Siow;Justin P. Richards;Kevin C. Pedley;David S. Leake

  • Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses

    Elizabeth C. Leigh-Firbank;Anne M. Minihane;David S. Leake;John W. Wright

  • Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2.

    Anila A. Anwar;Francois Y.L. Li;David S. Leake;Tetsuro Ishii

  • Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.

    Keri L.H. Carpenter;Ian F. Dennis;Iain R. Challis;David P. Osborn

  • Practical Approaches to Low Density Lipoprotein Oxidation: Whys, Wherefores and Pitfalls*

    Catherine Rice-evans;David Leake;K. Richard Bruckdorfer;Anthony T. Diplock

  • Acidic pH enables caeruloplasmin to catalyse the modification of low‐density lipoprotein

    David J. Lamb;David S. Leake

  • Transition metal ions within human atherosclerotic lesions can catalyse the oxidation of low density lipoprotein by macrophages

    David J. Lamb;Malcolm J. Mitchinson;David S. Leake

  • Low Density Lipoprotein Undergoes Oxidation Within Lysosomes in Cells

    Yichuan Wen;David Sidney Leake

  • Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells

    Richard C.M. Siow;Tetsuro Ishii;Hideyo Sato;Hideyo Sato;Shigeru Taketani

Frequent Co-Authors

Catherine Rice-Evans
Catherine Rice-Evans King's College London
Timothy J. Peters
Timothy J. Peters University of Bristol
Wendy Jessup
Wendy Jessup Concord Repatriation General Hospital
Tetsuro Ishii
Tetsuro Ishii University of Tsukuba
Shiro Bannai
Shiro Bannai University of Tsukuba
Parveen Yaqoob
Parveen Yaqoob University of Reading
Jeremy D. Pearson
Jeremy D. Pearson King's College London
Benjamin M. Chain
Benjamin M. Chain University College London
Philip C. Calder
Philip C. Calder University of Southampton
David R. Katz
David R. Katz University College London

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