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D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
15497
World Ranking
6425
National Ranking
2997

Overview

Daniel J. Donoghue is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant work in medicine. The scientist's studies extend into subfields including molecular biology, cell biology, oncology, genetics, and pulmonary and respiratory medicine.

Donoghue's main topics of research cover several areas, notably:

  • Fibroblast Growth Factor Research
  • Hippo pathway signaling and YAP/TAZ
  • Cancer Cells and Metastasis
  • Eosinophilic Disorders and Syndromes
  • Signaling Pathways in Disease
  • Protein Degradation and Inhibitors
  • Prostate Cancer Treatment and Research

The scientist has published extensively, with a notable presence in several journals and publication venues. Frequent venues for Donoghue's work include:

  • Oncotarget
  • Cytokine & Growth Factor Reviews
  • Zenodo (CERN European Organization for Nuclear Research)
  • Acta Neuropathologica Communications
  • American Journal of Medical Genetics Part A

Recent significant papers authored or co-authored by Donoghue include:

  • "Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment," 2021, Oncotarget
  • "Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness," 2022, Acta Neuropathologica Communications
  • "Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk," 2022, Cytokine & Growth Factor Reviews
  • "Typical achondroplasia secondary to a unique insertional variant of FGFR3 with in vitro demonstration of its effect on FGFR3 function," 2020, American Journal of Medical Genetics Part A
  • "Characterization of iPS87, a prostate cancer stem cell-like cell line," 2020, Oncotarget

Donoghue collaborates with several frequent co-authors, including:

  • April N. Meyer
  • Malalage N. Peiris
  • Martin Haas
  • Zian Jiang
  • Juyeon Ko

Best Publications

  • FGFR activation in skeletal disorders: too much of a good thing

    Melanie K. Webster;Daniel J. Donoghue

  • Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia.

    M. K. Webster;D. J. Donoghue

  • Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.

    Kristen C Hart;Scott C Robertson;Martha Y Kanemitsu;April N Meyer

  • Patched1 interacts with cyclin B1 to regulate cell cycle progression

    Elizabeth A. Barnes;Monica Kong;Vincent Ollendorff;Daniel J Donoghue

  • Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation

    Jianke Li;April N. Meyer;Daniel J. Donoghue

  • Antibiotic residues in poultry tissues and eggs: human health concerns?

    Dan J Donoghue

  • Cyclin B1 and CDK1: nuclear localization and upstream regulators

    Lisa A Porter;Daniel J Donoghue

  • cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2.

    M. S. Lee;S. Ogg;M. Xu;L. L. Parker

  • Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II.

    M K Webster;P Y D'Avis;S C Robertson;D J Donoghue

  • Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain.

    Scott C. Robertson;April N. Meyer;Kristen C. Hart;Brendan D. Galvin

  • RTK mutations and human syndromes: when good receptors turn bad

    Scott C Robertson;John A Tynan;Daniel J Donoghue

  • Effects of water- and lipid-soluble antioxidants on turkey sperm viability, membrane integrity, and motility during liquid storage

    A. M. Donoghue;D. J. Donoghue

  • Use of a specific bacteriophage treatment to reduce Salmonella in poultry products

    J. P. Higgins;S. E. Higgins;K. L. Guenther;W. Huff

  • Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus

    Charles Van Beveren;Janice A. Galleshaw;Vivian Jonas;Anton J. M. Berns;Anton J. M. Berns

  • Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype.

    Gary A. Bellus;Elaine B. Spector;Phyllis W. Speiser;Christine A. Weaver

  • A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene.

    Patricia L. Tavormina;Gary A. Bellus;Gary A. Bellus;Melanie K. Webster;Michael J. Bamshad

  • Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras

    Brendan D. Galvin;Kristen C. Hart;April N. Meyer;Melanie K. Webster

  • RTK mutations and human syndromeswhen good receptors turn bad.

    Scott C Robertson;John A Tynan;Daniel J Donoghue

  • Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase.

    Charlotte A. Bell;John A. Tynan;Kristen C. Hart;April N. Meyer

  • The importance of regulatory ubiquitination in cancer and metastasis.

    L. H. Gallo;J. Ko;D. J. Donoghue

Frequent Co-Authors

Ann M. Donoghue
Ann M. Donoghue United States Department of Agriculture
Kumar Venkitanarayanan
Kumar Venkitanarayanan University of Connecticut
Billy M. Hargis
Billy M. Hargis University of Arkansas at Fayetteville
Guillermo Tellez
Guillermo Tellez University of Arkansas at Fayetteville
William R. Wilcox
William R. Wilcox Emory University
Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Philip A. Moore
Philip A. Moore Agricultural Research Service
Clair A. Francomano
Clair A. Francomano Indiana University
Leslie M. Thompson
Leslie M. Thompson University of California, Irvine
Steven C. Ricke
Steven C. Ricke University of Wisconsin–Madison

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