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Microbiology

D-Index
55
Citations
13992
World Ranking
3779
National Ranking
1479

Overview

Cynthia L. Sears is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a particular focus on oncology and infectious diseases.

The main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Subfields of their research cover:

  • Molecular Biology
  • Oncology
  • Epidemiology
  • Infectious Diseases
  • Surgery

The scientist's work concentrates on key topics such as:

  • Gut microbiota and health
  • Cancer Immunotherapy and Biomarkers
  • Clostridium difficile and Clostridium perfringens research
  • Mycobacterium research and diagnosis
  • Colorectal Cancer Screening and Detection
  • Cancer Research and Treatments
  • Pancreatic and Hepatic Oncology Research

Cynthia L. Sears has published extensively, with frequent appearances in journals including:

  • Gastroenterology
  • The Journal of Infectious Diseases
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Discovery

Recent significant papers authored or co-authored by the scientist include:

  • Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps, 2021, Cell
  • A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes, 2021, Cancer Discovery
  • Intestinal Bacteria Maintain Adult Enteric Nervous System and Nitrergic Neurons via Toll-like Receptor 2-induced Neurogenesis in Mice, 2020, Gastroenterology
  • Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice, 2022, Cancer Discovery
  • Prevalence and association of pks+ Escherichia coli with colorectal cancer in patients at the University Malaya Medical Centre, Malaysia, 2020, PLoS ONE

Cynthia L. Sears collaborates frequently with other researchers, including:

  • Julia L. Drewes
  • Shaoguang Wu
  • James R. White
  • Fyza Y. Shaikh
  • Martha J. Shrubsole

Best Publications

  • Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

    Erick Riquelme;Erick Riquelme;Yu Zhang;Liangliang Zhang;Maria Montiel

  • Microbes, Microbiota, and Colon Cancer

    Cynthia L. Sears;Wendy S. Garrett

  • Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.

    Cynthia L. Sears;James B. Kaper

  • The emerging clinical importance of non-O157 Shiga toxin-producing Escherichia coli.

    Kristine E. Johnson;Cheleste M. Thorpe;Cynthia L. Sears

  • The Bacteroides fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients

    Annemarie Boleij;Elizabeth M. Hechenbleikner;Andrew C. Goodwin;Ruchi Badani

  • Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

    Heather M. O'Hagan;Wei Wang;Subhojit Sen;Christina DeStefano Shields

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • A dynamic partnership: celebrating our gut flora.

    Cynthia L. Sears

  • Enterotoxigenic Bacteroides fragilis: a Rogue among Symbiotes

    Cynthia L. Sears

  • Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation

    Shaoguang Wu;Patrice J. Morin;Djik Maouyo;Cynthia L. Sears

  • High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia.

    Julia L. Drewes;James R. White;Christine M. Dejea;Payam Fathi

  • Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice

    Ki Jong Rhee;Shaoguang Wu;Xinqun Wu;David L. Huso

  • Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and γ-secretase-dependent E-cadherin cleavage

    Shaoguang Wu;Ki Jong Rhee;Ming Zhang;Augusto Franco

  • Persistent Diarrhea Signals a Critical Period of Increased Diarrhea Burdens and Nutritional Shortfalls: A Prospective Cohort Study among Children in Northeastern Brazil

    A. A. M. Lima;S. R. Moore;M. S. Barboza;A. M. Soares

  • Perspective: Alpha-Bugs, Their Microbial Partners, and the Link to Colon Cancer

    Cynthia L. Sears;Drew M. Pardoll

  • Longitudinal Study of Cryptosporidium Infection in Children in Northeastern Brazil

    Robert D. Newman;Cynthia Louise Sears;Sean R. Moore;James P. Nataro

  • Bacteroides fragilis Enterotoxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 through Mitogen-Activated Protein Kinases and a Tyrosine Kinase-Regulated Nuclear Factor-κB Pathway

    Shaoguang Wu;Jan Powell;Nes Mathioudakis;Sheryl Kane

  • A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes.

    Sheetal Parida;Shaoguang Wu;Sumit Siddharth;Guannan Wang

  • Giardia duodenalis assemblage, clinical presentation and markers of intestinal inflammation in Brazilian children

    Anita Kohli;Oluma Y. Bushen;Relana C. Pinkerton;Eric Houpt

  • The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis.

    E Thiele Orberg;H Fan;A J Tam;C M Dejea

  • Microbiota dysbiosis in select human cancers: Evidence of association and causality.

    Jie Chen;Jada C. Domingue;Cynthia L. Sears

  • Triazole Cross-Resistance among Candida spp.: Case Report, Occurrence among Bloodstream Isolates, and Implications for Antifungal Therapy

    Shelley S. Magill;Christine Shields;Cynthia L. Sears;Michael Choti

Frequent Co-Authors

Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine
Franck Housseau
Franck Housseau Johns Hopkins University School of Medicine
James R. White
James R. White Johns Hopkins University School of Medicine
David L. Huso
David L. Huso Johns Hopkins University
James P. Nataro
James P. Nataro University of Virginia
Aldo A. M. Lima
Aldo A. M. Lima Universidade Federal do Ceará
Robert J. Coffey
Robert J. Coffey Vanderbilt University Medical Center
Robert A. Casero
Robert A. Casero Johns Hopkins University School of Medicine
Karen C. Carroll
Karen C. Carroll Johns Hopkins University School of Medicine
Aviv Regev
Aviv Regev Genentech

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