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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
20337
World Ranking
16925
National Ranking
6974

Overview

Clara Abraham is affiliated with Yale University in the United States. Their research primarily spans the fields of immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. The subfields of study include immunology, genetics, molecular biology, oncology, and epidemiology.

The scientist's work covers several major topics, notably:

  • Immune Cell Function and Interaction
  • Inflammatory Bowel Disease
  • Psoriasis: Treatment and Pathogenesis
  • IL-33, ST2, and ILC Pathways
  • Gut microbiota and health
  • Immune Response and Inflammation
  • Cytokine Signaling Pathways and Interactions

Among recent publications, Clara Abraham has contributed to the following papers:

  • The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair, 2021, Gastroenterology
  • IL-12 and IL-23 pathway inhibition in inflammatory bowel disease, 2023, Nature Reviews Gastroenterology & Hepatology
  • Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease, 2022, Gastroenterology
  • T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation, 2020, Cell Reports
  • Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response, 2021, Journal of Clinical Investigation

Clara Abraham has frequently published in venues such as:

  • Gastroenterology
  • Cellular and Molecular Gastroenterology and Hepatology
  • The Journal of Immunology
  • Nature Reviews Gastroenterology & Hepatology
  • Cell Reports

Frequent coauthors in their research include:

  • Matija Hedl
  • Jerrold R. Turner
  • Jie Yan
  • Kishu Ranjan
  • Rui Sun

Best Publications

  • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

    Luke Jostins;Stephan Ripke;Rinse K Weersma;Richard H Duerr

  • A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

    Richard H. Duerr;Kent D. Taylor;Steven R. Brant;Steven R. Brant;John D. Rioux;John D. Rioux

  • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

    Samuel Huber;Nicola Gagliani;Lauren A. Zenewicz;Francis J. Huber

  • Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

    Clara Abraham;Ruslan Medzhitov;Ruslan Medzhitov

  • Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

    Mark S. Silverberg;Judy H. Cho;John D. Rioux;Dermot P B McGovern

  • Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.

    Liping Su;Le Shen;Daniel R. Clayburgh;Sam C. Nalle

  • TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.

    Liping Su;Liping Su;Sam C. Nalle;Le Shen;Emily S. Turner

  • Interleukin‐23/Th17 pathways and inflammatory bowel disease

    Clara Abraham;Judy Cho

  • IFN-γ-Induced TNFR2 Expression Is Required for TNF-Dependent Intestinal Epithelial Barrier Dysfunction

    Fengjun Wang;Fengjun Wang;Brad T. Schwarz;W. Vallen Graham;Yingmin Wang

  • The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

    Laurence Menard;David Saadoun;Isabelle Isnardi;Yen Shing Ng

  • High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

    Philippe Goyette;Gabrielle Boucher;Dermot Mallon;Eva Ellinghaus

  • Regulation of IL-8 and IL-1β expression in Crohn's disease associated NOD2/CARD15 mutations

    Jing Li;Thomas Moran;Eric Swanson;Christina Julian

  • Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

    Shu Zhu;Siyuan Ding;Siyuan Ding;Penghua Wang;Zheng Wei

  • Chronic stimulation of Nod2 mediates tolerance to bacterial products.

    Matija Hedl;Jing Li;Judy H. Cho;Clara Abraham

  • The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair

    Wei-Ting Kuo;Li Zuo;Li Zuo;Matthew A. Odenwald;Shariq Madha

  • Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

    Ritu Sarin;Xingxin Wu;Clara Abraham

  • IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease.

    Clara Abraham;Judy H Cho

  • IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

    Yukihide Momozawa;Julia Dmitrieva;Emilie Théâtre;Valérie Deffontaine

  • A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

    Eimear E. Kenny;Itsik Pe'er;Amir Karban;Laurie Ozelius

  • Unraveling the Genetics of Autoimmunity

    Lauren A. Zenewicz;Clara Abraham;Richard A. Flavell;Richard A. Flavell;Judy H. Cho

Frequent Co-Authors

Judy H. Cho
Judy H. Cho Icahn School of Medicine at Mount Sinai
Jerrold R. Turner
Jerrold R. Turner Brigham and Women's Hospital
Richard A. Flavell
Richard A. Flavell Yale University
Steven R. Brant
Steven R. Brant Rutgers, The State University of New Jersey
Dermot P.B. McGovern
Dermot P.B. McGovern Cedars-Sinai Medical Center
Mark J. Daly
Mark J. Daly Massachusetts General Hospital
Richard H. Duerr
Richard H. Duerr University of Pittsburgh
Mark S. Silverberg
Mark S. Silverberg University of Toronto
Peter K. Gregersen
Peter K. Gregersen Feinstein Institute for Medical Research
Jerome I. Rotter
Jerome I. Rotter UCLA Medical Center

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