World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
69
Citations
29004
World Ranking
2578
National Ranking
1217

Biology and Biochemistry

D-Index
69
Citations
29005
World Ranking
7238
National Ranking
3321

Research.com Recognitions

  • 2018 - Member of the National Academy of Medicine (NAM)
  • 2017 - Fellow of the Royal Society of Canada Academy of Science
  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2001 - Fellow of Alfred P. Sloan Foundation

Overview

Azad Bonni is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these areas, their work is concentrated in subfields such as Molecular Biology, Neurology, Genetics, Cellular and Molecular Neuroscience, and Cognitive Neuroscience.

Their main topics of study include:

  • Parkinson's Disease Mechanisms and Treatments
  • Ubiquitin and proteasome pathways
  • Neurological disorders and treatments
  • Nuclear Receptors and Signaling
  • Epigenetics and DNA Methylation
  • Genetics and Neurodevelopmental Disorders
  • Autism Spectrum Disorder Research

Azad Bonni has published extensively in several scientific venues. Their most frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Medicine
  • Nature Communications
  • Cell Reports
  • Neurology

Some recent papers authored or co-authored by Bonni illustrate their focus on neurodegenerative disease and molecular neuroscience:

  • "Trial of Prasinezumab in Early-Stage Parkinson's Disease," 2022, New England Journal of Medicine
  • "Robust principal component analysis for accurate outlier sample detection in RNA-Seq data," 2020, BMC Bioinformatics
  • "Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease," 2024, Nature Medicine
  • "A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data," 2021, Frontiers in Neurology
  • "Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning," 2022, Nature

Azad Bonni collaborates regularly with a number of researchers. Frequent co-authors include:

  • Gennaro Pagano
  • Hanno Svoboda
  • Tania Nikolcheva
  • Paulo Fontoura
  • Tanya Simuni

Throughout their career, Bonni has been recognized with several awards. These include:

  • Member of the National Academy of Medicine (NAM), 2018
  • Fellow of the Royal Society of Canada, 2017 (Academy of Science)
  • Fellow of the American Association for the Advancement of Science (AAAS), 2016
  • Fellow of Alfred P. Sloan Foundation, 2001

Best Publications

  • Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

    Anne Brunet;Azad Bonni;Michael J Zigmond;Michael Z Lin

  • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.

    Azad Bonni;Anne Brunet;Anne E. West;Sandeep Robert Datta

  • Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

    Azad Bonni;Yi Sun;Mireya Nadal-Vicens;Ami Bhatt

  • A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span

    Maria K. Lehtinen;Zengqiang Yuan;Peter R. Boag;Peter R. Boag;Yue Yang

  • SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

    Philipp Oberdoerffer;Shaday Michan;Michael McVay;Raul Mostoslavsky

  • Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

    David D. Ginty;Azad Bonni;Michael E. Greenberg

  • The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases

    Shigeki Iwase;Fei Lan;Peter Bayliss;Luis de la Torre-Ubieta

  • Neuronal Activity-Dependent Cell Survival Mediated by Transcription Factor MEF2

    Zixu Mao;Azad Bonni;Fen Xia;Mireya Nadal-Vicens

  • A Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation

    Aryaman Shalizi;Brice Gaudillière;Zengqiang Yuan;Judith Stegmüller

  • Trial of Prasinezumab in Early-Stage Parkinson's Disease.

    Unknown

  • Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain

    Yoshiyuki Konishi;Judith Stegmüller;Takahiko Matsuda;Shirin Bonni

  • Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

    Núria De La Iglesia;Genevieve Konopka;Sidharth V. Puram;Jennifer A. Chan

  • Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery

    Yoshiyuki Konishi;Maria Lehtinen;Nicole Donovan;Azad Bonni

  • Cell cycle regulation of neuronal apoptosis in development and disease.

    Esther B.E Becker;Azad Bonni

  • Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals

    Azad Bonni;David D. Ginty;Henryk Dudek;Michael E. Greenberg

  • JNK Phosphorylation and Activation of BAD Couples the Stress-activated Signaling Pathway to the Cell Death Machinery

    Nicole Donovan;Esther B.E. Becker;Yoshiyuki Konishi;Azad Bonni

  • Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth

    Anna Lasorella;Judith Stegmüller;Daniele Guardavaccaro;Guangchao Liu

  • A CaMKII-NeuroD signaling pathway specifies dendritic morphogenesis

    Brice Gaudillière;Yoshiyuki Konishi;Núria de la Iglesia;Gui lan Yao

  • p38 MAP Kinase Mediates Apoptosis through Phosphorylation of BimEL at Ser-65

    Beibei Cai;Sandra H. Chang;Esther B.E. Becker;Azad Bonni

  • Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus

    Azad Bonni;David A. Frank;Chris Schindler;Michael E. Greenberg

  • A Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic Neurons

    Albert H. Kim;Sidharth V. Puram;Parizad M. Bilimoria;Yoshiho Ikeuchi

Frequent Co-Authors

Michael E. Greenberg
Michael E. Greenberg Harvard University
John N. Constantino
John N. Constantino Washington University in St. Louis
David A. Frank
David A. Frank Harvard University
Anne Brunet
Anne Brunet Stanford University
J. Wade Harper
J. Wade Harper Harvard Medical School
Steven P. Gygi
Steven P. Gygi Harvard University
Michael A. Rudnicki
Michael A. Rudnicki Ottawa Hospital Research Institute
Kirsten I. Taylor
Kirsten I. Taylor Roche (Switzerland)
David D. Ginty
David D. Ginty Howard Hughes Medical Institute
Hanno Steen
Hanno Steen Boston Children's Hospital

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