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Chemistry

D-Index
49
Citations
7986
World Ranking
14895
National Ranking
3800

Overview

Yvonne Lange is affiliated with Rush University Medical Center in the United States and conducts research primarily in the fields of biochemistry, genetics, molecular biology, and medicine. Their work is focused on molecular biology and cellular processes, with a notable emphasis on lipid membrane structure, cholesterol and lipid metabolism, and mechanisms related to drug transport and resistance. Additional areas of study include receptor mechanisms and signaling, sphingolipid metabolism and signaling, and topics involving caveolin-1 and peroxisome proliferator-activated receptors.

Lange's research output includes a combination of experimental and theoretical studies, often exploring the biochemical interactions of cholesterol within cell membranes and related biochemical pathways. They have published extensively on related topics, contributing to both fundamental models and applied research in lipid biochemistry.

Some of the recent papers authored or co-authored by Lange are:

  • Active cholesterol 20 years on, 2020, published in Traffic
  • A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding, 2023, published in Journal of Lipid Research

Lange has worked frequently with coauthors including Theodore L. Steck and S. M. Ali Tabei, indicating collaboration within a network of researchers specializing in related biomedical fields. Steck is a particularly frequent collaborator with seven joint works.

The main venues where Lange has published include:

  • Traffic
  • Journal of Lipid Research
  • Biochemistry
  • Progress in Lipid Research
  • bioRxiv (Cold Spring Harbor Laboratory)

The topics of work Lange is involved in cover:

  • Lipid Membrane Structure and Behavior
  • Cholesterol and Lipid Metabolism
  • Drug Transport and Resistance Mechanisms
  • Receptor Mechanisms and Signaling
  • Sphingolipid Metabolism and Signaling
  • Caveolin-1 and cellular processes
  • Peroxisome Proliferator-Activated Receptors

The subfields of study Lange contributes to include:

  • Molecular Biology
  • Surgery
  • Oncology
  • Cell Biology
  • Cancer Research

Lange's research integrates molecular and cellular biology approaches with biochemical insights, addressing complex biochemical interactions in health-related contexts, particularly in cholesterol biology and membrane dynamics. This work has implications for understanding cellular processes and may influence studies on drug transport and receptor signaling.

Best Publications

  • Plasma Membranes Contain Half the Phospholipid and 90% of the Cholesterol and Sphingomyelin in Cultured Human Fibroblasts*

    Y Lange;M H Swaisgood;B V Ramos;T L Steck

  • Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol.

    Yvonne Lange;Jin Ye;Mike Rigney;Theodore L. Steck

  • Probing Red Cell Membrane Cholesterol Movement with Cyclodextrin

    Theodore L. Steck;Jin Ye;Yvonne Lange

  • Cholesterol Movement in Niemann-Pick Type C Cells and in Cells Treated with Amphiphiles *

    Yvonne Lange;Jin Ye;Mike Rigney;Theodore L Steck

  • Disposition of intracellular cholesterol in human fibroblasts.

    Y Lange

  • The rate of transmembrane movement of cholesterol in the human erythrocyte.

    Y Lange;J Dolde;T L Steck

  • How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids

    Yvonne Lange;Jin Ye;Theodore L. Steck

  • Circulation of Cholesterol between Lysosomes and the Plasma Membrane

    Yvonne Lange;Jin Ye;Theodore L. Steck

  • Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol.

    Yvonne Lange;Theodore L. Steck

  • Cholesterol homeostasis. Modulation by amphiphiles.

    Y Lange;T L Steck

  • Cell cholesterol homeostasis: Mediation by active cholesterol

    Theodore L. Steck;Yvonne Lange

  • Interaction of chlorpromazine with the human erythrocyte membrane.

    M R Lieber;Y Lange;R S Weinstein;T L Steck

  • Tracking cell cholesterol with cholesterol oxidase.

    Yvonne Lange

  • Quantitation of the Pool of Cholesterol Associated with Acyl-CoA:Cholesterol Acyltransferase in Human Fibroblasts

    Yvonne Lange;Theodore L. Steck

  • Movement of 25-hydroxycholesterol from the plasma membrane to the rough endoplasmic reticulum in cultured hepatoma cells.

    Y. Lange;Jin Ye;F. Strebel

  • Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation.

    Drew M. Catron;Yvonne Lange;Jayme Borensztajn;Matthew D. Sylvester

  • Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.

    John P. Incardona;William Gaffield;Yvonne Lange;Adele Cooney

  • Role of the plasma membrane in cholesterol esterification in rat hepatoma cells.

    Y. Lange;F. Strebel;T.L. Steck

  • The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55.

    Drew M. Catron;Matthew D. Sylvester;Yvonne Lange;Madhusudan Kadekoppala

  • The effect of cholesterol and other intercalated amphipaths on the contour and stability of the isolated red cell membrane.

    Y Lange;H B Cutler;T L Steck

  • Interaction of cholesterol and lysophosphatidylcholine in determining red cell shape

    Yvonne Lange;James M. Slayton

  • The affinity of cholesterol for phosphatidylcholine and sphingomyelin

    Yvonne Lange;Josephine S. D'Alessandro;Donald M. Small

Frequent Co-Authors

Theodore L. Steck
Theodore L. Steck University of Chicago
Kasturi Haldar
Kasturi Haldar University of Notre Dame
Ka Yee C. Lee
Ka Yee C. Lee University of Chicago
Bradley D. Jones
Bradley D. Jones University of Iowa
Daniel S. Ory
Daniel S. Ory Washington University in St. Louis
Fong-Fu Hsu
Fong-Fu Hsu Washington University in St. Louis
Peter G. Pentchev
Peter G. Pentchev National Institutes of Health
Stanley Falkow
Stanley Falkow Stanford University
J. Glenn Songer
J. Glenn Songer University of Arizona
Denise M. Monack
Denise M. Monack Stanford University

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