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Genetics

D-Index
44
Citations
14969
World Ranking
4242
National Ranking
480

Overview

Vardhman K. Rakyan is affiliated with Queen Mary University of London in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a significant body of work in Medicine. The scientist's expertise concentrates notably in Molecular Biology, Genetics, and areas linked to Pediatrics, Perinatology, and Child Health, as well as Periodontics and Hematology.

Their research topics cover a variety of biomedical themes including Epigenetics and DNA Methylation, RNA modifications and cancer, and Birth, Development, and Health. Additional focal points include Genomic variations and chromosomal abnormalities, Cancer-related gene regulation, RNA and protein synthesis mechanisms, and Oral microbiology and periodontitis research.

Vardhman K. Rakyan has contributed scholarly articles primarily in the following publication venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Genome biology
  • Aging
  • Cell Genomics

Significant recent papers authored by Rakyan encompass:

  • "Ribosomal DNA copy number is associated with body mass in humans and other mammals" (2024, Nature Communications)
  • "Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states" (2022, Genome biology)
  • "Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma" (2021, Nature Communications)
  • "DNA methylation clocks as a predictor for ageing and age estimation in naked mole-rats, Heterocephalus glaber" (2020, Aging)
  • "The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations" (2020, PLoS Genetics)

Frequent collaborators in their research include:

  • Francisco Rodríguez-Algarra
  • Michelle L. Holland
  • Sarah J. Marzi
  • Selin Yildizoglu
  • Pui Pik Law

The volume and diversity of their work indicate a research career engaged deeply with molecular and genetic mechanisms underpinning health and disease, with a consistent focus on epigenetic regulation and RNA biology.

Best Publications

  • DNA methylation profiling of human chromosomes 6, 20 and 22

    Florian Eckhardt;Joern Lewin;Rene Cortese;Vardhman K Rakyan

  • Epigenome-wide association studies for common human diseases

    Vardhman K. Rakyan;Thomas A. Down;David J. Balding;Stephan Beck

  • Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

    Vardhman K. Rakyan;Thomas A. Down;Siarhei Maslau;Toby Andrew

  • A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

    Thomas A. Down;Vardhman K. Rakyan;Daniel J. Turner;Paul Flicek

  • Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission

    Vardhman K. Rakyan;Suyinn Chong;Marnie E. Champ;Peter C. Cuthbert

  • DNA methylation aging clocks: challenges and recommendations

    Christopher G Bell;Robert Lowe;Peter D Adams;Peter D Adams;Andrea A Baccarelli

  • Metastable epialleles in mammals

    Vardhman K Rakyan;Marnie E Blewitt;Riki Druker;Jost I Preis

  • DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome Project

    Vardhman K Rakyan;Thomas Hildmann;Karen L Novik;Jörn Lewin

  • An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)

    Vardhman K. Rakyan;Thomas A. Down;Natalie P. Thorne;Paul Flicek

  • Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

    Vardhman K. Rakyan;Huriya Beyan;Thomas A. Down;Mohammed I. Hawa

  • BLUEPRINT to decode the epigenetic signature written in blood

    David Adams;Lucia Altucci;Stylionos E. Antonarakis;Juan Ballesteros

  • Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

    Christopher G Bell;Andrew E Teschendorff;Vardhman K Rakyan;Alexander P Maxwell

  • Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

    Christopher G. Bell;Sarah Finer;Cecilia M. Lindgren;Gareth A. Wilson

  • The methylome: approaches for global DNA methylation profiling.

    Stephan Beck;Vardhman K. Rakyan

  • BulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files.

    Alexander Payne;Nadine Holmes;Vardhman K. Rakyan;Matthew Loose

  • Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene IMPLICATIONS FOR FEEDBACK AUTOREGULATION OF ACTIVE VITAMIN D LEVELS AT THE FETOMATERNAL INTERFACE

    Boris Novakovic;Mandy Sibson;Hong Kiat Ng;Hong Kiat Ng;Ursula Chandini Manuelpillai

  • The marks, mechanisms and memory of epigenetic states in mammals.

    Vardhman K. Rakyan;Jost Preis;Hugh D. Morgan;Emma Whitelaw

  • From genome to epigenome

    Adele Murrell;Vardhman K. Rakyan;Stephan Beck

  • Correlation of an epigenetic mitotic clock with cancer risk

    Zhen Yang;Andrew Wong;Diana Kuh;Dirk S. Paul

  • Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies.

    Robert Lowe;Carolina Gemma;Huriya Beyan;Mohammed I. Hawa

Frequent Co-Authors

Stephan Beck
Stephan Beck University College London
Andrew E. Teschendorff
Andrew E. Teschendorff University College London
Thomas A. Down
Thomas A. Down Wellcome/Cancer Research UK Gurdon Institute
Dirk S. Paul
Dirk S. Paul University of Cambridge
Bernhard O. Boehm
Bernhard O. Boehm Nanyang Technological University
Martin Widschwendter
Martin Widschwendter University College London
Sreeram V. Ramagopalan
Sreeram V. Ramagopalan University of Oxford
Richard Saffery
Richard Saffery University of Melbourne
Jeffrey M. Craig
Jeffrey M. Craig Deakin University

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