Ruth Luthi-Carter

Best Publications

• Regional and cellular gene expression changes in human Huntington's disease brain.

  Angela Kaye Hodges;Andrew D. Strand;Aaron K. Aragaki;Alexandre Kuhn

  951
  Citations

• Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease

  Ruth Luthi-Carter;Andrew Strand;Nikki L. Peters;Steven M. Solano

  881
  Citations

• Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

  Robert J. Ferrante;James K. Kubilus;Junghee Lee;Hoon Ryu

  848
  Citations

• Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

  Ruth Luthi-Carter;Sarah A. Hanson;Andrew D. Strand;Donald A. Bergstrom

  460
  Citations

• SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

  Ruth Luthi-Carter;David M. Taylor;Judit Pallos;Emmanuel Lambert

  393
  Citations

• Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

  Mali Jiang;Jiawei Wang;Jiawei Wang;Jinrong Fu;Lin Du

  368
  Citations

• Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease.

  Paolo Guidetti;Ruth E Luthi-Carter;Sarah J Augood;Robert Schwarcz

  351
  Citations

• Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

  Ruth Luthi-Carter;Andrew D. Strand;Sarah A. Hanson;Charles Kooperberg

  312
  Citations

• Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

  Alexandre Kuhn;Darlene R. Goldstein;Angela Hodges;Angela Hodges;Andrew D. Strand

  312
  Citations

• Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

  Alexandre Kuhn;Doris Thu;Henry J Waldvogel;Richard L M Faull

  289
  Citations

• Sustained effects of nonallele-specific Huntingtin silencing†

  Valérie Drouet;Valérie Drouet;Valérie Perrin;Raymonde Hassig;Raymonde Hassig;Noëlle Dufour;Noëlle Dufour

  250
  Citations

• Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease.

  Doris C. V. Thu;Dorothy E. Oorschot;Lynette J. Tippett;Alissa L. Nana

  243
  Citations

• Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

  John Labbadia;Helen Cunliffe;Andreas Weiss;Elena Katsyuba

  209
  Citations

• HTT-lowering reverses Huntington’s disease immune dysfunction caused by NFκB pathway dysregulation

  Ulrike Träger;Ralph Andre;Nayana Lahiri;Anna Magnusson-Lind;Anna Magnusson-Lind

  201
  Citations

• HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

  Michal Mielcarek;Christian Landles;Andreas Weiss;Amyaouch Bradaia

  193
  Citations

• MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington"s Disease-Related Mechanisms

  Ana Jovicic;Julien Francisco Zaldivar Jolissaint;Roger Moser;Mariana de Fatima Silva Santos

  193
  Citations

• Biological and potential therapeutic roles of sirtuin deacetylases.

  D. M. Taylor;M. M. Maxwell;R. Luthi-Carter;A. G. Kazantsev

  192
  Citations

• What have we learned from gene expression profiles in Huntington's disease?

  Tamara Seredenina;Ruth Luthi-Carter

  189
  Citations

• A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase.

  David M. Taylor;Uma Balabadra;Zhongmin Xiang;Ben Woodman

  187
  Citations

• Neuroprotection by Hsp104 and Hsp27 in Lentiviral-based Rat Models of Huntington's Disease

  Valérie Perrin;Etienne Régulier;Toufik Abbas-Terki;Raymonde Hassig

  171
  Citations