Richard E. Heikkila

Best Publications

• Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

  WilliamdotJ. Nicklas;Ivy Vyas;Richard E. Heikkila

  1832
  Citations

• Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors.

  Richard E. Heikkila;Lawrence Manzino;Felicitas S. Cabbat;Roger C. Duvoisin

  1525
  Citations

• Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice

  Richard E. Heikkila;Arthur Hess;Roger C. Duvoisin

  1514
  Citations

• Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity

  Patricia K. Sonsalla;William J. Nicklas;Richard E. Heikkila

  734
  Citations

• Studies on the distinction between uptake inhibition and release of [3H]dopamine in rat brain tissue slices

  Unknown

  468
  Citations

• Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

  Richard E. Heikkila;William J. Nicklas;Ivy Vyas;Roger C. Duvoisin

  404
  Citations

• MPTP, MPP+ and mitochondrial function.

  W J Nicklas;S K Youngster;M V Kindt;R E Heikkila

  353
  Citations

• Studies on the Neurotoxicity of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine: Inhibition of NAD‐Linked Substrate Oxidation by Its Metabolite, 1‐Methyl‐4‐Phenylpyridinium

  Ivy Vyas;Richard E. Heikkila;William J. Nicklas

  344
  Citations

• Amphetamine: evaluation of d- and l-isomers as releasing agents and uptake inhibitors for 3H-dopamine and 3H-norepinephrine in slices of rat neostriatum and cerebral cortex.

  R E Heikkila;H Orlansky;C Mytilineou;G Cohen

  328
  Citations

• Hydrogen peroxide production by rat brain in vivo.

  Pierre M. Sinet;Richard E. Heikkila;Gerald Cohen

  285
  Citations

• Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.

  P K Sonsalla;D E Riordan;R E Heikkila

  278
  Citations

• Behavioral correlations of dopamine receptor activation

  Oscar Gershanik;Richard E. Heikkila;Roger C. Duvoisin

  226
  Citations

• The developing neostriatum of the rabbit: Correlation of fluorescence histochemistry, electron microscopy, endogenous dopamine levels, and [3H]dopamine uptake

  Unknown

  223
  Citations

• Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.

  Richard E. Heikkila;Beth-Anne Sieber;Lawrence Manzino;Patricia K. Sonsalla

  207
  Citations

• Inhibition of Biogenic Amine Uptake by Hydrogen Peroxide: A Mechanism for Toxic Effects of 6-Hydroxydopamine

  Unknown

  204
  Citations

• Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration.

  A Giovanni;B A Sieber;R E Heikkila;P K Sonsalla

  195
  Citations

• TETRAHYDROISOQUINOLINE ALKALOIDS: UPTAKE BY RAT BRAIN HOMOGENATES AND INHIBITION OF CATECHOLAMINE UPTAKE

  Richard Heikkila;Gerald Cohen;Dorothy Dembiec

  183
  Citations

• Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport.

  Mayer Ra;Kindt Mv;Heikkila Re

  178
  Citations

• Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice

  A Giovanni;B A Sieber;R E Heikkila;P K Sonsalla

  170
  Citations

• Long-term duodenal infusion of levodopa for motor fluctuations in parkinsonism.

  J. I. Sage;S. Trooskin;P. K. Sonsalla;R. Heikkila

  164
  Citations