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45
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11776
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574

Overview

Rainer Freynhagen is affiliated with the Technical University of Munich in Germany and has made contributions primarily in the field of medicine, with a focus on understanding and treating pain. Their research spans several subfields including physiology, pharmacology, neurology, anesthesiology, pain medicine, and cognitive neuroscience.

The scientist's body of work focuses on topics related to pain mechanisms and treatments, musculoskeletal pain and rehabilitation, botulinum toxin and related neurological disorders, pain management including opioid use, the placebo effect, and myofascial pain diagnosis and treatment. These areas highlight a comprehensive engagement with both the physiological and clinical aspects of pain research.

Freynhagen has coauthored multiple papers with frequent collaborators including Ralf Baron, Thomas R. Tölle, Rolf-Detlef Treede, Nadine Attal, and Per Hansson. These collaborations have been instrumental in advancing various aspects of pain research.

The scientist has published extensively in several journals, with the most frequent venues being:

  • Pain
  • Current Medical Research and Opinion
  • PAIN Reports
  • Pain Medicine
  • Journal of Neural Transmission

The following are selected recent publications by Rainer Freynhagen:

  • No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy, 2020, Pain
  • Progressive Response to Repeat Application of Capsaicin 179 mg (8% w/w) Cutaneous Patch in Peripheral Neuropathic Pain: Comprehensive New Analysis and Clinical Implications, 2021, Pain Medicine
  • When to consider "mixed pain"? The right questions can make a difference!, 2020, Current Medical Research and Opinion
  • Botulinum neurotoxin injections for muscle-based (dystonia and spasticity) and non-muscle-based (neuropathic pain) pain disorders: a meta-analytic study, 2020, Journal of Neural Transmission
  • Contralateral Sensory and Pain Perception Changes in Patients With Unilateral Neuropathy, 2021, Neurology

These publications reflect an ongoing investigation into neuropathic pain, sensory profiles, treatment with agents like capsaicin and botulinum toxin, and clinical considerations in differentiating pain types.

Best Publications

  • painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain

    Rainer Freynhagen;Ralf Baron;Ulrich Gockel;Thomas R. Tölle

  • Using screening tools to identify neuropathic pain

    Michael I. Bennett;Nadine Attal;Miroslav M. Backonja;Ralf Baron

  • Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles.

    Ralf Baron;Christoph Maier;Nadine Attal;Andreas Binder

  • Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens

    Unknown

  • A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms

    Ralf Baron;Thomas R. Tölle;Ulrich Gockel;Mathias Brosz

  • Ziconotide for treatment of severe chronic pain

    Achim Schmidtko;Jörn Lötsch;Rainer Freynhagen;Gerd Geisslinger

  • The evaluation of neuropathic components in low back pain

    Rainer Freynhagen;Ralf Baron

  • Duloxetine and pregabalin: high-dose monotherapy or their combination? The "COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain.

    Solomon Tesfaye;Stefan Wilhelm;Alberto Lledo;Alexander Schacht

  • Pregabalin for relief of neuropathic pain associated with diabetic neuropathy: a randomized, double-blind study.

    Thomas Tölle;Rainer Freynhagen;Mark Versavel;Uwe Trostmann

  • Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients.

    A. Koch;K. Zacharowski;O. Boehm;M. Stevens

  • Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Answers from quantitative sensory testing

    Rainer Freynhagen;Roman Rolke;Ralf Baron;Thomas R. Tölle

  • Diagnosis and management of neuropathic pain

    R. J. Freynhagen;Michael I. Bennett

  • A cross-sectional survey of 3035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles

    Stefanie E Rehm;Jana Koroschetz;Ulrich Gockel;Mathias Brosz

  • The painDETECT project – far more than a screening tool on neuropathic pain

    Rainer Freynhagen;Thomas R. Tölle;Ulrich Gockel;Ralf Baron

  • Current understanding of the mixed pain concept: a brief narrative review

    Rainer Freynhagen;Harold Arevalo Parada;Carlos Alberto Calderon-Ospina;Juythel Chen

  • Stratifying patients with peripheral neuropathic pain based on sensory profiles : algorithm and sample size recommendations

    Jan Vollert;Jan Vollert;Christoph Maier;Nadine Attal;David L H Bennett

  • The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy.

    Ralf Baron;Rainer Freynhagen;Thomas R. Tölle;Christian Cloutier

  • Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT)

    Rainer Freynhagen;Ralf Baron;Thomas Tölle;Edgar Stemmler

  • Fibromyalgia and neuropathic pain - differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia

    Jana Koroschetz;Stefanie E Rehm;Ulrich Gockel;Mathias Brosz

  • Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers.

    Jörn Lötsch;Nils von Hentig;Rainer Freynhagen;Norbert Griessinger

  • Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: Data from the randomized, double-blind, COMBO-DN study

    Didier Bouhassira;Stefan Wilhelm;Alexander Schacht;Serge Perrot

Frequent Co-Authors

Thomas R. Tölle
Thomas R. Tölle Technical University of Munich
Rolf-Detlef Treede
Rolf-Detlef Treede Heidelberg University
Per Hansson
Per Hansson Karolinska Institute
Märta Segerdahl
Märta Segerdahl Karolinska Institute
Christoph Maier
Christoph Maier Ruhr University Bochum
Nadine Attal
Nadine Attal Grenoble Alpes University
Roman Rolke
Roman Rolke RWTH Aachen University
Nanna B. Finnerup
Nanna B. Finnerup Aarhus University
Giorgio Cruccu
Giorgio Cruccu Sapienza University of Rome
Claudia Sommer
Claudia Sommer University of Würzburg

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