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Pravinkumar B. Sehgal

Pravinkumar B. Sehgal

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
18218
World Ranking
6313
National Ranking
2958

Overview

Pravinkumar B. Sehgal is affiliated with Rockefeller University in the United States. Their research primarily spans the fields of Medicine and Agricultural and Biological Sciences, with a focus on Infectious Diseases, Animal Science and Zoology, Epidemiology, and Genetics.

They have contributed to studies on a range of topics related to viral infections, including:

  • Animal Virus Infections Studies
  • SARS-CoV-2 and COVID-19 Research
  • Influenza Virus Research Studies
  • Viral Infections and Vectors
  • Virus-based gene therapy research
  • Viral gastroenteritis research and epidemiology

Their recent publications illustrate their concentration on viral pathogens affecting animals, including coronaviruses and influenza viruses. These publications include:

  • "Highly Pathogenic Avian Influenza A (H5N1) Clade 2.3.2.1a virus infection in domestic cats, India, 2025" (2025), published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Establishment of an ex vivo lung explant culture model for dogs and cats to study SARS-CoV-2 infection" (2024), published in the International Journal of Advanced Biochemistry Research
  • "Comparative temporal transcriptome analyses of SARS-CoV-2 delta and omicron variants ex-vivo infection in cat lung explant culture" (2025), published in Frontiers in Cellular and Infection Microbiology

Throughout these works, Pravinkumar B. Sehgal has frequently collaborated with several coauthors, indicating an active research network. Frequent coauthors include:

  • Ashwin Ashok Raut
  • Sandeep Bhatia
  • Anamika Mishra
  • Atul Kumar Pateriya
  • A. S. Panwar

The scientist's publications have appeared in specialized journals relevant to infectious disease and molecular biology, with repeated contributions to bioRxiv (Cold Spring Harbor Laboratory), the International Journal of Advanced Biochemistry Research, and Frontiers in Cellular and Infection Microbiology.

Best Publications

  • Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

    Rachel M. Grossman;James Krueger;Debra Yourish;Angela Granelli-Piperno

  • Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

    Masayoshi Kohase;Dorothy Henriksen-DeStefano;Lester T. May;Jan Vilček

  • Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

    Uma Santhanam;Anuradha Ray;Pravinkumar B. Sehgal

  • The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and Gram stain in patients with preterm labor and intact membranes

    Roberto Romero;Bo Hyun Yoon;Moshe Mazor;Ricardo Gomez

  • A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.

    Harold S. Ginsberg;Lyle L. Moldawer;Pravinkumar B. Sehgal;Miriam Redington

  • Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man.

    Y Fong;L L Moldawer;M Marano;H Wei

  • On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion.

    A Ray;K S LaForge;P B Sehgal

  • Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6).

    Giovanna Tosato;Kenneth B. Seamon;Neil D. Goldman;Pravinkumar B. Sehgal

  • A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1.

    M Kohase;L T May;I Tamm;J Vilcek

  • A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes***

    Roberto Romero;Bo Hyun Yoon;Moshe Mazor;Ricardo Gomez

  • Cytokine-induced production of IFN-beta 2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17 beta.

    S S Tabibzadeh;U Santhanam;P B Sehgal;L T May

  • Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes.

    L. T. May;J. Ghrayeb;Uma Santhanam;S. B. Tatter

  • Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists.

    Anuradha Ray;Stephen B. Tatter;Lester T. May;Pravinkumar B. Sehgal

  • Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.

    Lester T. May;David C. Helfgott;Pravinkumar B. Sehgal

  • Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection.

    D C Helfgott;S B Tatter;U Santhanam;R H Clarick

  • Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical

    Pravinkumar B. Sehgal;Lester T. May;Igor Tamm;Jan Vilček

  • The inhibition of DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells

    Pravinkumar B. Sehgal;James E. Darnell;Igor Tamm

  • Halobenzimidazole Ribosides and RNA Synthesis of Cells and Viruses

    Igor Tamm;Pravinkumar B. Sehgal

  • Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts.

    D C Helfgott;L T May;Z Sthoeger;I Tamm

  • Heterogeneity of poly(I).poly(C)-induced human fibroblast interferon mRNA species

    Pravinkumar B. Sehgal;Anurag D. Sagar

Frequent Co-Authors

Igor Tamm
Igor Tamm Rockefeller University
Jan Vilcek
Jan Vilcek New York University
Roberto Romero
Roberto Romero National Institutes of Health
Lyle L. Moldawer
Lyle L. Moldawer University of Florida
James E. Darnell
James E. Darnell Rockefeller University
Frank H. Ruddle
Frank H. Ruddle Yale University
Nina Bhardwaj
Nina Bhardwaj Icahn School of Medicine at Mount Sinai
Masayori Inouye
Masayori Inouye Rutgers, The State University of New Jersey
Ricardo Gomez
Ricardo Gomez Pontificia Universidad Católica de Chile
Anne M. Bowcock
Anne M. Bowcock Icahn School of Medicine at Mount Sinai

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