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D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
12455
World Ranking
12537
National Ranking
431

Overview

Philippe Séguéla is affiliated with the Montreal Neurological Institute and Hospital in Canada. Their research primarily spans several interconnected fields including Neuroscience, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these, Séguéla has concentrated on subfields such as Cellular and Molecular Neuroscience, Physiology, Molecular Biology, Psychiatry and Mental Health, and Cognitive Neuroscience.

The main scientific topics covered in Séguéla's body of work include Pain Mechanisms and Treatments, Neuroscience and Neuropharmacology Research, Ion Channel Regulation and Function, Adenosine and Purinergic Signaling, Neuropeptides and Animal Physiology, Fibromyalgia and Chronic Fatigue Syndrome Research, and Pain Management and Placebo Effect.

Séguéla has contributed to a number of research papers published between 2019 and 2021. Notable works include:

  • Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons, 2020, Neuron
  • Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain, 2021, Cell Reports
  • Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus, 2020, Molecular Brain
  • Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice, 2020, Molecular Psychiatry
  • Chronic lithium treatment alters the excitatory/inhibitory balance of synaptic networks and reduces mGluR5-PKC signalling in mouse cortical neurons, 2021, Journal of Psychiatry and Neuroscience

Their research has been disseminated through several publication venues including bioRxiv (Cold Spring Harbor Laboratory), Journal of the Neurological Sciences, Neuron, Cell Reports, and Nature Neuroscience.

Séguéla frequently collaborates with other researchers. Key coauthors in their work are:

  • Kevin Lançon
  • Behrang Sharif
  • Ariel R. Ase
  • Alfredo Ribeiro-da-Silva
  • Calvin Wong

Best Publications

  • Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

    P Seguela;J Wadiche;K Dineley-Miller;JA Dani

  • International Union of Pharmacology. XXIV. Current Status of the Nomenclature and Properties of P2X Receptors and Their Subunits

    Khakh Bs;Burnstock G;Kennedy C;King Bf

  • Antibodies against gamma-aminobutyric acid: specificity studies and immunocytochemical results.

    P Seguela;M Geffard;R M Buijs;M Le Moal

  • An N-terminal variant of Trpv1 channel is required for osmosensory transduction

    Reza Sharif Naeini;Marie-France Witty;Philippe Séguéla;Charles W Bourque

  • Central P2X4 and P2X6 Channel Subunits Coassemble into a Novel Heteromeric ATP Receptor

    Khanh-Tuoc Lê;Kazimierz Babinski;Philippe Séguéla

  • First demonstration of highly specific and sensitive antibodies against dopamine.

    M. Geffard;R. M. Buijs;P. Seguela;C. W. Pool

  • A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain

    P Seguela;A Haghighi;JJ Soghomonian;E Cooper

  • TNP-ATP-resistant P2X ionic current on the central terminals and somata of rat primary sensory neurons.

    Kenzo Tsuzuki;Ariel Ase;Philippe Séguéla;Terumasa Nakatsuka

  • Downregulation of Tonic GABAergic Inhibition in a Mouse Model of Fragile X Syndrome

    Giulia Curia;Thomas Papouin;Thomas Papouin;Philippe Séguéla;Massimo Avoli;Massimo Avoli

  • A Protein Kinase C Site Highly Conserved in P2X Subunits Controls the Desensitization Kinetics of P2X2 ATP-gated Channels *

    Éric Boué-Grabot;Vincent Archambault;Philippe Séguéla

  • P2X receptor channels in chronic pain pathways.

    Louis-Philippe Bernier;Ariel R Ase;Philippe Séguéla

  • Noradrenaline axon terminals in adult rat neocortex: An immunocytochemical analysis in serial thin sections

    P. Séguéla;K.C. Watkins;M. Geffard;L. Descarries

  • Mammalian ASIC2a and ASIC3 Subunits Co-assemble into Heteromeric Proton-gated Channels Sensitive to Gd3+

    Kazimierz Babinski;Stefano Catarsi;Giuseppe Biagini;Philippe Séguéla

  • ADP and AMP Induce Interleukin-1β Release from Microglial Cells through Activation of ATP-Primed P2X7 Receptor Channels

    Yassar Chakfe;Rosanne Seguin;Jack P. Antel;Céline Morissette

  • Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels.

    I Bouchelet;Z Cohen;B Case;P Séguéla

  • Molecular Cloning and Regional Distribution of a Human Proton Receptor Subunit with Biphasic Functional Properties

    Kazimierz Babinski;Khanh‐Tuoc Lê;Philippe Séguéla

  • Remote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice

    I. Daou;A. H. Tuttle;G. Longo;J. S. Wieskopf

  • Ultrastructural features of dopamine axon terminals in the anteromedial and the suprarhinal cortex of adult rat

    Philippe Séguéla;Kenneth C. Watkins;Laurent Descarries

  • Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors

    K.-T. Leˆ;P. Villeneuve;A.R. Ramjaun;P.S. McPherson

  • Nicotine receptors in the mammalian brain.

    Charles W. Luetje;Jim Patrick;Philippe Séguéla

Frequent Co-Authors

Alfredo Ribeiro-da-Silva
Alfredo Ribeiro-da-Silva McGill University
Philip A. Barker
Philip A. Barker University of British Columbia
Laurent Descarries
Laurent Descarries University of Montreal
Jack P. Antel
Jack P. Antel McGill University
Jeffrey S. Mogil
Jeffrey S. Mogil McGill University
Edith Hamel
Edith Hamel Montreal Neurological Institute and Hospital
André Parent
André Parent Université Laval
Angel Alonso
Angel Alonso Montreal Neurological Institute and Hospital
Diomedes E. Logothetis
Diomedes E. Logothetis Northeastern University
Amit Bar-Or
Amit Bar-Or University of Pennsylvania

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