His scientific interests lie mostly in Receptor, Cell biology, Biochemistry, Homomeric and Protein subunit. In his works, Philippe Séguéla conducts interdisciplinary research on Receptor and Trigeminovascular system. His Cell biology research includes elements of D2-like receptor and Cys-loop receptors.
His Biochemistry research incorporates themes from Glutaraldehyde and Antiserum. His work deals with themes such as Xenopus and Ion channel, which intersect with Protein subunit. In his study, Neuroscience is inextricably linked to TRPV1, which falls within the broad field of Endocrinology.
His primary scientific interests are in Neuroscience, Receptor, Cell biology, Biochemistry and Homomeric. His Neuroscience research incorporates elements of Nociceptor and Nociception. His Receptor study incorporates themes from Extracellular and Pharmacology.
The concepts of his Cell biology study are interwoven with issues in Endocrinology, Xenopus, Microglia, Internal medicine and Metabotropic receptor. His studies examine the connections between Xenopus and genetics, as well as such issues in Protein subunit, with regards to Ion channel, Molecular biology and Peptide sequence. His Biochemistry study deals with Biophysics intersecting with Reversal potential.
Philippe Séguéla mainly investigates Neuroscience, Receptor, Cell biology, Optogenetics and Nociceptor. His Neuroscience study frequently draws parallels with other fields, such as Nociception. His study in the fields of Purinergic receptor under the domain of Receptor overlaps with other disciplines such as P2RX7.
The study incorporates disciplines such as In vitro, Neurotrophin, Ion channel and Metabotropic receptor in addition to Cell biology. Homomeric is closely connected to Membrane potential in his research, which is encompassed under the umbrella topic of Ion channel. His biological study spans a wide range of topics, including Peripheral and Opioid.
Neuroscience, Nociceptor, Nociception, Calcium and Pharmacology are his primary areas of study. In the field of Neuroscience, his study on Neuropathic pain and Electrophysiology overlaps with subjects such as Prefrontal cortex. His studies deal with areas such as Optogenetics and Channelrhodopsin as well as Nociceptor.
His Cell biology research extends to the thematically linked field of Calcium. His research in Cell biology tackles topics such as Antagonism which are related to areas like Microglia and Neuroinflammation. His Pharmacology study combines topics in areas such as Calcium in biology and Receptor.
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Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
P Seguela;J Wadiche;K Dineley-Miller;JA Dani.
The Journal of Neuroscience (1993)
International Union of Pharmacology. XXIV. Current Status of the Nomenclature and Properties of P2X Receptors and Their Subunits
Baljit S. Khakh;Geoffrey Burnstock;Charles Kennedy;Brian F. King.
Pharmacological Reviews (2001)
Antibodies against gamma-aminobutyric acid: specificity studies and immunocytochemical results.
P Seguela;M Geffard;R M Buijs;M Le Moal.
Proceedings of the National Academy of Sciences of the United States of America (1984)
An N-terminal variant of Trpv1 channel is required for osmosensory transduction
Reza Sharif Naeini;Marie-France Witty;Philippe Séguéla;Charles W Bourque.
Nature Neuroscience (2006)
Central P2X4 and P2X6 Channel Subunits Coassemble into a Novel Heteromeric ATP Receptor
Khanh-Tuoc Lê;Kazimierz Babinski;Philippe Séguéla.
The Journal of Neuroscience (1998)
First demonstration of highly specific and sensitive antibodies against dopamine.
M. Geffard;R. M. Buijs;P. Seguela;C. W. Pool.
Brain Research (1984)
A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain
P Seguela;A Haghighi;JJ Soghomonian;E Cooper.
The Journal of Neuroscience (1996)
TNP-ATP-resistant P2X ionic current on the central terminals and somata of rat primary sensory neurons.
Kenzo Tsuzuki;Ariel Ase;Philippe Séguéla;Terumasa Nakatsuka.
Journal of Neurophysiology (2003)
Downregulation of Tonic GABAergic Inhibition in a Mouse Model of Fragile X Syndrome
Giulia Curia;Thomas Papouin;Thomas Papouin;Philippe Séguéla;Massimo Avoli;Massimo Avoli.
Cerebral Cortex (2009)
A Protein Kinase C Site Highly Conserved in P2X Subunits Controls the Desensitization Kinetics of P2X2 ATP-gated Channels *
Éric Boué-Grabot;Vincent Archambault;Philippe Séguéla.
Journal of Biological Chemistry (2000)
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