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Chemistry

D-Index
51
Citations
8226
World Ranking
14095
National Ranking
785

Research.com Recognitions

  • 2016 - Longstaff Prize, Royal Society of Chemistry (UK)
  • 1999 - Meldola Medal and Prize, Royal Society of Chemistry (UK)

Overview

Peter O'Brien is a researcher affiliated with the University of York in the United Kingdom. Their work spans the fields of Chemistry and Biochemistry, Genetics and Molecular Biology, with a strong focus on sub-disciplines such as Organic Chemistry, Molecular Biology, Materials Chemistry, Computational Theory and Mathematics, and Biomedical Engineering.

The scientist's research primarily covers topics including Chemical Synthesis and Analysis, Computational Drug Discovery Methods, Innovative Microfluidic and Catalytic Techniques Innovation, Catalytic Cross-Coupling Reactions, Coordination Chemistry and Organometallics, Crystallization and Solubility Studies, and X-ray Diffraction in Crystallography.

Selected recent publications demonstrate a concentration on fragment-based drug discovery and crystallographic screening. They include:

  • Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease, 2020, Nature Communications
  • Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking, 2021, Science Advances
  • Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Design and Synthesis of 56 Shape-Diverse 3D Fragments, 2020, Chemistry - A European Journal
  • Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries, 2022, Drug Discovery Today

Frequent collaborators in research include James D. Firth, Hanna F. Klein, Roderick E. Hubbard, Simon Jones, and Thomas D. Downes.

Their work has appeared repeatedly in several publication venues, such as Zenodo (CERN European Organization for Nuclear Research), The Cambridge Structural Database, bioRxiv (Cold Spring Harbor Laboratory), Chemistry - A European Journal, and Nature Chemistry.

Peter O'Brien has been recognized with awards including the Longstaff Prize from the Royal Society of Chemistry (UK) in 2016 and the Meldola Medal and Prize from the same society in 1999.

Best Publications

  • Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.

    Alice Douangamath;Daren Fearon;Paul Gehrtz;Tobias Krojer

  • Sharpless Asymmetric Aminohydroxylation: Scope, Limitations, and Use in Synthesis.

    Peter O'Brien

  • Synthesis of Spirocyclic Indolenines

    Michael J. James;Peter O'Brien;Richard J. K. Taylor;William P. Unsworth

  • A readily-accessible (+)-sparteine surrogate

    Michael J. Dearden;Catherine R. Firkin;Jean-Paul R. Hermet;Peter O'brien

  • Recent advances in asymmetric synthesis using chiral lithium amide bases

    Peter O’Brien

  • Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.

    Marion Schuller;Galen J. Correy;Stefan Gahbauer;Daren Fearon

  • Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects

    Darren Stead;Giorgio Carbone;Peter O’Brien;Kevin R. Campos

  • Silver(I)‐ or Copper(II)‐Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds

    Michael J. James;James D. Cuthbertson;Peter O'Brien;Richard J. K. Taylor

  • Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications.

    Graeme Barker;Julia L. McGrath;Artis Klapars;Darren Stead

  • Catalytic asymmetric synthesis of ferrocenes and P-stereogenic bisphosphines

    Cédric Genet;Steven J. Canipa;Peter O'brien;Sven Taylor

  • Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles

    Michael J. James;Rosa E. Clubley;Kleopas Y. Palate;Thomas J. Procter

  • Catalyst-Driven Scaffold Diversity: Selective Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones.

    John T R Liddon;Michael J James;Aimee K Clarke;Peter O'Brien

  • A New Sparteine Surrogate for Asymmetric Deprotonation of N-Boc Pyrrolidine

    Darren Stead;Peter O'Brien;Adam Sanderson

  • Catalytic asymmetric deprotonation using a ligand exchange approach.

    Matthew J. McGrath;Peter O'Brien

  • Basic instinct: design, synthesis and evaluation of (+)-sparteine surrogates for asymmetric synthesis.

    Peter O'Brien

  • Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones.

    Hon Eong Ho;Angela Pagano;James A. Rossi-Ashton;James R. Donald

  • Evaluation of (+)-sparteine-like diamines for asymmetric synthesis.

    Michael J. Dearden;Matthew J. Mcgrath;Peter O'brien

  • Silica-Supported Silver Nitrate as a Highly Active Dearomatizing Spirocyclization Catalyst: Synergistic Alkyne Activation by Silver Nanoparticles and Silica.

    Aimee K. Clarke;Michael J. James;Peter O'Brien;Richard J. K. Taylor

  • Synthesis of P-stereogenic compounds via kinetic deprotonation and dynamic thermodynamic resolution of phosphine sulfides: opposite sense of induction using (-)-sparteine.

    Jonathan J. Gammon;Viktoria H. Gessner;Greg R. Barker;Johan Granander

  • Asymmetric deprotonation using s-BuLi or i-PrLi and chiral diamines in THF: the diamine matters.

    Giorgio Carbone;Peter O'Brien;Göran Hilmersson

  • Diamine-Free Lithiation−Trapping of N-Boc Heterocycles using s-BuLi in THF

    Graeme Barker;Peter O’Brien;Kevin R. Campos

  • An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters

    Nadeem S. Sheikh;Daniele Leonori;Graeme Barker;James D. Firth

  • Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

    Alice Douangamath;Daren Fearon;Paul Gehrtz;Tobias Krojer

Frequent Co-Authors

Adrian C. Whitwood
Adrian C. Whitwood University of York
Roderick E. Hubbard
Roderick E. Hubbard University of York
Jonathan Clayden
Jonathan Clayden University of Bristol
Paul R. Raithby
Paul R. Raithby University of Bath
Brian M. Stoltz
Brian M. Stoltz California Institute of Technology
Iwan J. P. de Esch
Iwan J. P. de Esch Vrije Universiteit Amsterdam
Carsten Strohmann
Carsten Strohmann TU Dortmund University
Martin E.M. Noble
Martin E.M. Noble Newcastle University
Jason E. Gestwicki
Jason E. Gestwicki University of California, San Francisco
Alan Ashworth
Alan Ashworth University of California, San Francisco

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