Osamu Takikawa

Best Publications

• Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.

  Gilles J. Guillemin;George Smythe;Osamu Takikawa;Bruce J. Brew;Bruce J. Brew

  555
  Citations

• Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells.

  Aikou Okamoto;Takashi Nikaido;Kazunori Ochiai;Satoshi Takakura

  553
  Citations

• Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

  Unknown

  467
  Citations

• Inhibition of experimental asthma by indoleamine 2,3-dioxygenase

  Tomoko Hayashi;Lucinda Beck;Cyprian Rossetto;Xing Gong

  454
  Citations

• Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism.

  Osamu Takikawa

  453
  Citations

• Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus

  G. J. Guillemin;B. J. Brew;C. E. Noonan;O. Takikawa

  370
  Citations

• Characterization of the kynurenine pathway in human neurons.

  Gilles J. Guillemin;Karen M. Cullen;Chai K. Lim;George A. Smythe

  362
  Citations

• Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

  Unknown

  357
  Citations

• Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer.

  K Ino;N Yoshida;H Kajiyama;K Shibata

  331
  Citations

• Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: its association with disease progression and survival.

  Kazuhiko Ino;Eiko Yamamoto;Kiyosumi Shibata;Hiroaki Kajiyama

  304
  Citations

• Lipopolysaccharide induction of indoleamine 2,3‐dioxygenase is mediated dominantly by an IFN‐γ‐independent mechanism

  Suwako Fujigaki;Kuniaki Saito;Kenji Sekikawa;Shigenobu Tone

  298
  Citations

• Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma.

  Tomoko Inaba;Kazuhiko Ino;Hiroaki Kajiyama;Eiko Yamamoto

  279
  Citations

• Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO)

  Juliana Croitoru-Lamoury;Francois Mj Lamoury;Michael Caristo;Kazuo Suzuki

  270
  Citations

• IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-γ increase in normal pregnancy but decrease in spontaneous abortion

  Naoko Miwa;Satoshi Hayakawa;Satomi Miyazaki;Subaru Myojo

  243
  Citations

• Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme

  Unknown

  241
  Citations

• Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells.

  Manuela Brenk;Marina Scheler;Susanne Koch;Jürgen Neumann

  230
  Citations

• Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer.

  Takafumi Nakamura;Tomoko Shima;Ai Saeki;Takao Hidaka

  210
  Citations

• Expression of Indoleamine 2,3-Dioxygenase in Tumor Endothelial Cells Correlates with Long-term Survival of Patients with Renal Cell Carcinoma

  Rainer Riesenberg;Christoph Weiler;Oliver Spring;Martin Eder

  195
  Citations

• Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis.

  Raghava Potula;Larisa Poluektova;Larisa Poluektova;Larisa Poluektova;Bryan Knipe;Bryan Knipe;Bryan Knipe;Jesse Chrastil;Jesse Chrastil;Jesse Chrastil

  188
  Citations

• Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

  Yoko Tajima;Masaki Ishikawa;Keiko Maekawa;Mayumi Murayama

  182
  Citations