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Biology and Biochemistry

D-Index
70
Citations
14689
World Ranking
7139
National Ranking
3277

Overview

O. John Semmes is affiliated with the Eastern Virginia Medical School in the United States. Their research spans several domains within medicine and molecular biology, focused primarily on prostate cancer treatment and related biomedical fields.

Semmes has published extensively across multiple venues. Frequent publication outlets include:

  • Proceedings of the National Academy of Sciences
  • Cancer Epidemiology Biomarkers & Prevention
  • PLoS Pathogens
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Prostate

The main fields of study covered in Semmes's publications are Medicine and Biochemistry, Genetics and Molecular Biology. Within those broader fields, prominent subfields include Pulmonary and Respiratory Medicine, Molecular Biology, Spectroscopy, Immunology, and Cancer Research.

Their research topics concentrate on:

  • Prostate Cancer Treatment and Research
  • Mass Spectrometry Techniques and Applications
  • Extracellular Vesicles in Disease
  • Advanced Proteomics Techniques and Applications
  • Glycosylation and Glycoproteins Research
  • Immunotherapy and Immune Responses
  • T-cell and Retrovirus Studies

Semmes has frequently collaborated with several co-authors, including:

  • Julius O. Nyalwidhe
  • Brian P. Main
  • Paul C. Boutros
  • Dean A. Troyer
  • Thomas Kislinger

Recent notable publications by Semmes include:

  • Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes, 2024, Nature Communications
  • Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis, 2022, Journal of Extracellular Vesicles
  • NF-κB-induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia, 2021, Proceedings of the National Academy of Sciences
  • Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles, 2021, Frontiers in Chemistry
  • Prostate Cancer Biomarker Development: National Cancer Institute's Early Detection Research Network Prostate Cancer Collaborative Group Review, 2020, Cancer Epidemiology Biomarkers & Prevention

Best Publications

  • Serum Protein Fingerprinting Coupled with a Pattern-matching Algorithm Distinguishes Prostate Cancer from Benign Prostate Hyperplasia and Healthy Men

    Bao Ling Adam;Yinsheng Qu;John W. Davis;Michael D. Ward

  • Boosted Decision Tree Analysis of Surface-enhanced Laser Desorption/Ionization Mass Spectral Serum Profiles Discriminates Prostate Cancer from Noncancer Patients

    Yinsheng Qu;Bao Ling Adam;Yutaka Yasui;Michael D. Ward

  • Evaluation of Serum Protein Profiling by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Detection of Prostate Cancer: I. Assessment of Platform Reproducibility

    O. John Semmes;Ziding Feng;Bao Ling Adam;Lionel L. Banez

  • Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

    Julia Laskin;Brandi S. Heath;Patrick J. Roach;Lisa H. Cazares

  • Clinical proteomics: A need to define the field and to begin to set adequate standards.

    Harald Mischak;Rolf Apweiler;Rosamonde E. Banks;Mark Conaway

  • Recommendations for Biomarker Identification and Qualification in Clinical Proteomics

    Harald Mischak;Guenter Allmaier;Rolf Apweiler;Teresa Attwood

  • Lectin Capture Strategies Combined with Mass Spectrometry for the Discovery of Serum Glycoprotein Biomarkers

    Richard R. Drake;E. Ellen Schwegler;Gunjan Malik;Jose Diaz

  • Imaging Mass Spectrometry of a Specific Fragment of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 2 Discriminates Cancer from Uninvolved Prostate Tissue

    Lisa H. Cazares;Dean Troyer;Savvas Mendrinos;Raymond A. Lance

  • Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometry.

    Lisa H. Cazares;Bao Ling Adam;Michael D. Ward;Suhail Nasim

  • Proteomic approaches to biomarker discovery in prostate and bladder cancers.

    Bao Ling Adam;Antonia Vlahou;Oliver John Semmes;George L. Wright

  • Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells

    S Mehdi Belgnaoui;Roger G Gosden;O John Semmes;Abdelali Haoudi

  • Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response

    Susan J Marriott;Oliver John Semmes

  • SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma.

    E. Ellen Schwegler;Lisa Cazares;Laura F. Steel;Bao Ling Adam

  • Serum Levels of an Isoform of Apolipoprotein A-II as a Potential Marker for Prostate Cancer

    Gunjan Malik;Michael D. Ward;Saurabh K. Gupta;Michael W. Trosset

  • A Novel Approach Toward Development of a Rapid Blood Test for Breast Cancer

    Antonia Vlahou;Christine Laronga;Lori Wilson;Betsy Gregory

  • National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Clinical Practice: Quality Requirements

    Catharine M. Sturgeon;Barry R. Hoffman;Daniel W. Chan;Soo Ling Ch'ng

  • In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

    Simona Principe;E. Ellen Jones;Yunee Kim;Ankit Sinha

  • Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1

    Sarah Welbourn;Sucharita M. Dutta;O. John Semmes;Klaus Strebel

  • Serum protein profiles to identify head and neck cancer.

    J. Trad Wadsworth;Kenneth D. Somers;Lisa H. Cazares;Gunjan Malik

  • Serum Protein Fingerprinting Coupled with a Pattern-matching Algorithm Distinguishes Prostate Cancer from Benign Prostate Hyperplasia and Healthy Men 1

    Bao-Ling Adam;Yinsheng Qu;John W. Davis;Michael D. Ward

Frequent Co-Authors

Michael D. Ward
Michael D. Ward New York University
Ziding Feng
Ziding Feng Fred Hutchinson Cancer Research Center
Thomas Kislinger
Thomas Kislinger University of Toronto
William E. Grizzle
William E. Grizzle University of Alabama at Birmingham
Yutaka Yasui
Yutaka Yasui St. Jude Children's Research Hospital
Daniel W. Chan
Daniel W. Chan Johns Hopkins University School of Medicine
Paul F. Schellhammer
Paul F. Schellhammer Eastern Virginia Medical School
Ian M. Thompson
Ian M. Thompson The University of Texas Health Science Center at San Antonio
Jeffrey A. Medin
Jeffrey A. Medin Medical College of Wisconsin
Anand Mehta
Anand Mehta Medical University of South Carolina

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