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Nicholas R. Waterfield

Nicholas R. Waterfield

Overview

Nicholas R. Waterfield is affiliated with the University of Warwick in the United Kingdom. Their research spans multiple disciplines including Biochemistry, Genetics and Molecular Biology, Agricultural and Biological Sciences, and Medicine. The scientist's work also covers subfields such as Insect Science, Genetics, Molecular Biology, Epidemiology, and Ecology.

The research topics frequently explored by Waterfield include:

  • Entomopathogenic Microorganisms in Pest Control
  • Bacterial Genetics and Biotechnology
  • Bacillus and Francisella bacterial research
  • Insect symbiosis and bacterial influences
  • Insect and Pesticide Research
  • Bacteriophages and microbial interactions
  • Yersinia bacterium, plague, ectoparasites research

Waterfield has published numerous papers, with recent notable works including:

  • Genome-wide dissection reveals diverse pathogenic roles of bacterial Tc toxins, 2021, PLoS Pathogens
  • Application of Quantitative PCR in the Diagnosis and Evaluating Treatment Efficacy of Leishmaniasis, 2020, Frontiers in Cellular and Infection Microbiology
  • A new family of globally distributed lytic roseophages with unusual deoxythymidine to deoxyuridine substitution, 2021, Current Biology
  • N-Glycans and sulfated glycosaminoglycans contribute to the action of diverse Tc toxins on mammalian cells, 2021, PLoS Pathogens
  • Detection of Pneumocystis jirovecii and Toxoplasma gondii in patients with lung infections by a duplex qPCR assay, 2021, PLoS neglected tropical diseases

Frequent collaborators of Waterfield include:

  • Alexia Hapeshi
  • Guowei Yang
  • Yun Wu
  • Shathviga Manoharan
  • Grace Taylor-Joyce

The scientist has contributed to a variety of publication venues. Key journals and platforms where their work has appeared include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Microbiology
  • PLoS Pathogens
  • PLoS neglected tropical diseases
  • Frontiers in Cellular and Infection Microbiology

Best Publications

  • A single Photorhabdus gene, makes caterpillars floppy (mcf), allows Escherichia coli to persist within and kill insects

    P. J. Daborn;N. Waterfield;C. P. Silva;C. P. Y. Au

  • Insecticidal toxins from Photorhabdus bacteria and their potential use in agriculture.

    Richard H. ffrench-Constant;Andrea Dowling;Nicholas R. Waterfield

  • A Pseudomonas aeruginosa Type VI Secretion Phospholipase D Effector Targets Both Prokaryotic and Eukaryotic Cells

    Feng Jiang;Nicholas R. Waterfield;Jian Yang;Guowei Yang

  • Photorhabdus and a host of hosts.

    Nicholas R. Waterfield;Todd Ciche;David Clarke

  • The tc genes of Photorhabdus: a growing family

    Nicholas R Waterfield;David J Bowen;Jacqueline D Fetherston;Robert D Perry

  • Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen.

    Richard Ffrench-Constant;Nicholas Waterfield;Phillip Daborn;Susan Joyce

  • Photorhabdus virulence cassettes confer injectable insecticidal activity against the wax moth.

    G. Yang;A. J. Dowling;U. Gerike;R. H. ffrench-Constant

  • Bacterial infection of a model insect: Photorhabdus luminescens and Manduca sexta

    Carlos P. Silva;Nicholas R. Waterfield;Phillip J. Daborn;Paul Dean

  • Sequencing and Analysis of the Prolate-Headed Lactococcal Bacteriophage c2 Genome and Identification of the Structural Genes

    M. W. Lubbers;N. R. Waterfield;T. P. J. Beresford;R. W. F. Le Page

  • The KdpD/KdpE two-component system: integrating K⁺ homeostasis and virulence.

    Zoë N. Freeman;Stephen Dorus;Nicholas R. Waterfield

  • A genomic sample sequence of the entomopathogenic bacterium Photorhabdus luminescens W14: potential implications for virulence.

    Richard H. Ffrench-Constant;Nicholas Waterfield;Valerie Burland;Nicole T. Perna

  • An ABC guide to the bacterial toxin complexes.

    Richard Ffrench-Constant;Nicholas Waterfield

  • The Photorhabdus Pir toxins are similar to a developmentally regulated insect protein but show no juvenile hormone esterase activity.

    Nicholas Waterfield;Shizuo George Kamita;Bruce D. Hammock;Richard Ffrench-Constant

  • Human infection with Photorhabdus asymbiotica: an emerging bacterial pathogen

    John Gerrard;Nicholas Waterfield;Renu Vohra;Richard ffrench-Constant

  • Potentiation and cellular phenotypes of the insecticidal Toxin complexes of Photorhabdus bacteria.

    N. Waterfield;M. Hares;G. Yang;A. Dowling

  • The Pseudomonas aeruginosa Type VI Secretion PGAP1-like Effector Induces Host Autophagy by Activating Endoplasmic Reticulum Stress

    Feng Jiang;Xia Wang;Bei Wang;Lihong Chen

  • Invertebrates as a source of emerging human pathogens

    Nicholas R. Waterfield;Brendan W. Wren;Richard H. ffrench-Constant

  • Comparative genomics of the emerging human pathogen Photorhabdus asymbiotica with the insect pathogen Photorhabdus luminescens

    Paul Wilkinson;Nicholas R Waterfield;Lisa Crossman;Craig Corton

  • Measuring virulence factor expression by the pathogenic bacterium Photorhabdus luminescens in culture and during insect infection.

    Phillip J. Daborn;Nicholas Waterfield;Mark A. Blight;Richard H. Ffrench-Constant

  • Evolution of microbial virulence: the benefits of stress.

    Dawn L. Arnold;Robert W. Jackson;Nick R. Waterfield;John W. Mansfield

Frequent Co-Authors

Richard H. ffrench-Constant
Richard H. ffrench-Constant University of Exeter
Julian Parkhill
Julian Parkhill University of Cambridge
Nicholas R. Thomson
Nicholas R. Thomson Wellcome Sanger Institute
Brendan W. Wren
Brendan W. Wren London School of Hygiene & Tropical Medicine
Narisara Chantratita
Narisara Chantratita Mahidol University
Edward J. Feil
Edward J. Feil University of Bath
Qi Jin
Qi Jin Peking Union Medical College Hospital
Sharon J. Peacock
Sharon J. Peacock University of Cambridge
Michael A. Quail
Michael A. Quail Wellcome Sanger Institute
Michael Otto
Michael Otto National Institutes of Health

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