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Biology and Biochemistry

D-Index
53
Citations
9226
World Ranking
16249
National Ranking
246

Overview

Mikael Rhen is affiliated with the Karolinska Institute in Sweden. Their research primarily focuses on the intersection of microbiology, molecular biology, and immunology. Over their career, they have contributed to several research areas including Salmonella and Campylobacter epidemiology, bacteriophages and microbial interactions, immune response and inflammation, DNA repair mechanisms, Vibrio bacteria studies, bacterial genetics and biotechnology, and urinary tract infection management.

The main fields of study associated with Mikael Rhen's work are Biochemistry, Genetics and Molecular Biology, as well as Immunology and Microbiology. Their subfields include Food Science, Immunology, Ecology, Endocrinology, and Molecular Biology.

They have frequently co-authored with researchers such as Maria Fällman, Kemal Avican, Jehad Aldahdooh, Matteo Togninalli, and Jing Tang. Publication venues where Mikael Rhen's work has appeared include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Frontiers in Microbiology, Frontiers in Cellular and Infection Microbiology, and Cell Reports.

Recent papers authored or co-authored by Mikael Rhen are:

  • RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection, 2021, Nature Communications
  • Nitrate Metabolism Modulates Biosynthesis of Biofilm Components in Uropathogenic Escherichia coli and Acts as a Fitness Factor During Experimental Urinary Tract Infection, 2020, Frontiers in Microbiology
  • Replication of Salmonella enterica serovar Typhimurium in RAW264.7 Phagocytes Correlates With Hypoxia and Lack of iNOS Expression, 2020, Frontiers in Cellular and Infection Microbiology
  • Influence of the microenvironment on modulation of the host response by typhoid toxin, 2021, Cell Reports
  • An optotracer-based antibiotic susceptibility test specifically targeting the biofilm lifestyle of Salmonella, 2022, Biofilm

The breadth of Mikael Rhen's research topics reflect a comprehensive engagement with bacterial pathogenesis, microbial ecology, host-pathogen interactions, and applied microbiology methods. This includes investigation of bacterial stress responses during infection, metabolic pathways affecting biofilm formation, and the development of specialized antibiotic susceptibility tests targeting biofilm-forming bacteria.

Best Publications

  • Molecular analysis of spv virulence genes of the salmonella virulence plasmids

    Paul A. Gulig;Hirofumi Danbara;Donald G. Guiney;Alistair J. Lax

  • Activation of the contact-phase system on bacterial surfaces—a clue to serious complications in infectious diseases

    Heiko Herwald;Matthias Mörgelin;Arne Olsén;Mikael Rhen

  • Escherichia coli fimbriae recognizing sialyl galactosides.

    T K Korhonen;V Väisänen-Rhen;M Rhen;A Pere

  • Mesenteric Lymph Nodes Confine Dendritic Cell-Mediated Dissemination of Salmonella enterica Serovar Typhimurium and Limit Systemic Disease in Mice

    Sabrina Voedisch;Christian Koenecke;Sascha David;Heike Herbrand

  • Actin is ADP‐ribosylated by the Salmonella enterica virulence‐associated protein SpvB

    Dilek Tezcan-Merdol;Tomas Nyman;Uno Lindberg;Friedrich Haag

  • Binding of Escherichia coli S fimbriae to human kidney epithelium.

    Timo K. Korhonen;Jaakko Parkkinen;Jörg Hacker;Jukka Finne

  • The spvB gene‐product of the Salmonella enterica virulence plasmid is a mono(ADP‐ribosyl)transferase

    Helge Otto;Dilek Tezcan-Merdol;Roman Girisch;Friedrich Haag

  • Uptake and replication of Salmonella enterica in Acanthamoeba rhysodes.

    Dilek Tezcan-Merdol;Marianne Ljungström;Jadwiga Winiecka-Krusnell;Ewert Linder;Ewert Linder

  • Expression of thin aggregative fimbriae promotes interaction of Salmonella typhimurium SR-11 with mouse small intestinal epithelial cells.

    Soila Sukupolvi;Robin G. Lorenz;Jeffrey I. Gordon;Zhao Bian

  • P-fimbriae of Escherichia coli are subject to phase variation

    Mikael Rhen;P.Helena Mäkelä;Timo K. Korhonen

  • High abundance of virulence gene homologues in marine bacteria

    Olof P. Persson;Jarone Pinhassi;Lasse Riemann;Britt-Inger Marklund

  • Cyclic di-GMP signalling controls virulence properties of Salmonella enterica serovar Typhimurium at the mucosal lining

    Agaristi Lamprokostopoulou;Claudia Monteiro;Mikael Rhen;Ute Römling

  • Location of adhesion sites for P-fimbriated and for 075X-positive Escherichia coli in the human kidney

    Bogdan Nowicki;Harry Holthöfer;Timo Saraneva;Mikael Rhen

  • Regulation of biofilm formation in Salmonella enterica serovar Typhimurium

    Roger Simm;Irfan Ahmad;Mikael Rhen;Soazig Le Guyon

  • Salmonella typhimurium mutants that downregulate phagocyte nitric oxide production.

    Sofia Eriksson;Johanna Björkman;Stefan Borg;Anna Syk

  • P fimbriae of Escherichia coli: Molecular cloning of DNA fragments containing the structural genes

    Mikael Rhen;Jonathan Knowles;Merja E. Penttilä;Matti Sarvas

  • TRANSCRIPTIONAL REGULATION OF SALMONELLA-ENTERICA VIRULENCE PLASMID GENES IN CULTURED MACROPHAGES

    Mikael Rhen;Petri Riikonen;Suvi Taira

  • Role of rpoS in the regulation of Salmonella plasmid virulence (spv) genes.

    Pipsa Heiskanen;Suvi Taira;Mikael Rhen

  • The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection

    Lisa Del Bel Belluz;Riccardo Guidi;Ioannis S. Pateras;Laura Levi

  • Independent bottlenecks characterize colonization of systemic compartments and gut lymphoid tissue by salmonella.

    Chee Han Lim;Sabrina Voedisch;Benjamin Wahl;Syed Fazle Rouf

Frequent Co-Authors

Timo K. Korhonen
Timo K. Korhonen University of Helsinki
P. Helena Mäkelä
P. Helena Mäkelä University of Helsinki
Harry Holthöfer
Harry Holthöfer University of Helsinki
Donald G. Guiney
Donald G. Guiney University of California, San Diego
Gunilla Källenius
Gunilla Källenius Karolinska Institute
Stefan B. Svenson
Stefan B. Svenson Swedish University of Agricultural Sciences
Per Klemm
Per Klemm Technical University of Denmark
Matti Saraste
Matti Saraste European Bioinformatics Institute
Merja Penttilä
Merja Penttilä Aalto University

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