2026 Michael L. Freeman: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	65	9314	8594	4112	3689	229	12806

Overview

Michael L. Freeman is affiliated with Vanderbilt University Medical Center in the United States. Their research primarily focuses on medicine with several subfields including surgery, sensory systems, physiology, epidemiology, and public health, environmental and occupational health.

The scientist's work encompasses a variety of topics such as:

Helicobacter pylori-related gastroenterology studies
Ion Channels and Receptors
HIV/AIDS oral health manifestations
Gastrointestinal motility and disorders
Congenital gastrointestinal and neural anomalies
Cardiovascular, Neuropeptides, and Oxidative Stress Research
Biochemical effects in animals

Freeman has contributed publications to frequent venues, including:

American Journal of Physiology-Gastrointestinal and Liver Physiology
Scientific Medical Data
Biomedicine & Pharmacotherapy
Surgery
Frontiers in Medicine

Notable recent papers authored or co-authored by Freeman include:

"Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function," 2022, American Journal of Physiology-Gastrointestinal and Liver Physiology
"Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice," 2021, Biomedicine & Pharmacotherapy
"Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications," 2022, Surgery
"Inhibition of GSK-3β restores delayed gastric emptying in obesity-induced diabetic female mice," 2020, American Journal of Physiology-Gastrointestinal and Liver Physiology
"A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific," 2023, Frontiers in Medicine

Freeman frequently collaborates with other researchers including:

Chethan Sampath
Pandu R. Gangula
Shanthi Srinivasan
Eva Poveda López
Abhinav V. Raju

Best Publications

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.

Fei Hong;Michael L Freeman;Daniel C Liebler

469
Citations
Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

Swati Biswas;Marta Guix;Cammie Rinehart;Teresa C. Dugger

406
Citations
A System of Cytokines Encapsulated in ExtraCellular Vesicles

Wendy Fitzgerald;Michael L. Freeman;Michael Marcel Lederman;Elena Vasilieva

390
Citations
Specific Patterns of Electrophile Adduction Trigger Keap1 Ubiquitination and Nrf2 Activation

Fei Hong;Konjeti R. Sekhar;Michael L. Freeman;Daniel C. Liebler

387
Citations
Novel n-3 Fatty Acid Oxidation Products Activate Nrf2 by Destabilizing the Association between Keap1 and Cullin3 *

Ling Gao;Jiakun Wang;Konjeti R. Sekhar;Huiyong Yin

344
Citations
Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo

Nancy J. Brown;Shinya Nakamura;Lijun Ma;Ikuko Nakamura

343
Citations
Age-related retinopathy in NRF2-deficient mice

Zhenyang Zhao;Yan Chen;Jian Wang;Paul Sternberg

330
Citations
Cell biology of hyperthermia and radiation

W.C. Dewey;D.P. Highfield;M.L. Freeman;R.A. Coss

310
Citations
Modulation of plasminogen activator inhibitor-1 in vivo: A new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition

Tsuyoshi Oikawa;Michael Freeman;Wilbur Lo;Douglas E. Vaughan

301
Citations
Double-Strand Break Repair Deficiency and Radiation Sensitivity in BRCA2 Mutant Cancer Cells

Derek W. Abbott;Michael L. Freeman;Jeffrey T. Holt

278
Citations
Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.

Jingbo Pi;Yushi Bai;Jeffrey M. Reece;Jason Williams

257
Citations
Survivin As a Therapeutic Target for Radiation Sensitization in Lung Cancer

Bo Lu;Yi Mu;Carolyn Cao;Fenghua Zeng

249
Citations
Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

Girish Rachakonda;Ying Xiong;Konjeti R. Sekhar;Sheryl L. Stamer

241
Citations
Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling.

Kwang Woon Kim;Robert W. Mutter;Carolyn Cao;Jeffrey M. Albert

231
Citations
Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections.

Michael L. Freeman;Brian S. Sheridan;Robert H. Bonneau;Robert L. Hendricks

222
Citations
NADPH oxidase limits innate immune responses in the lungs in mice.

Brahm H. Segal;Brahm H. Segal;Wei Han;Jennifer J. Bushey;Myungsoo Joo

213
Citations
Cysteine-based regulation of the CUL3 adaptor protein Keap1.

Konjeti R. Sekhar;Girish Rachakonda;Michael L. Freeman

185
Citations
Inflammatory chemokine receptors regulate CD8+ T cell contraction and memory generation following infection

Jacob E. Kohlmeier;William W. Reiley;Georgia Perona-Wright;Michael L. Freeman

176
Citations
Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas

Donnie R. Stacy;Kim Ely;Pierre P. Massion;Wendell G. Yarbrough

168
Citations
Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2.

Konjet R Sekhar;Xue Xian Yan;Michael L Freeman

164
Citations