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Biology and Biochemistry

D-Index
52
Citations
15918
World Ranking
16467
National Ranking
6816

Overview

Lukas Chavez is affiliated with the University of California, San Diego in the United States. Their research expertise spans the fields of Biochemistry, Genetics, and Molecular Biology, with a strong focus also on Medicine. Within these domains, they have contributed notably to Molecular Biology, Genetics, Cancer Research, Oncology, and Epidemiology.

Their scientific output includes numerous publications concentrated on topics such as Glioma Diagnosis and Treatment, Cancer Genomics and Diagnostics, RNA modifications and cancer, Cancer-related molecular mechanisms research, Protein Degradation and Inhibitors, Epigenetics and DNA Methylation, and Ferroptosis and cancer prognosis.

Among their recent published works are:

  • "Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma" (2020, Neuro-Oncology)
  • "The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies" (2020, Cancer Discovery)
  • "Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma" (2023, Nature Genetics)
  • "PTEN deficiency leads to proteasome addiction: a novel vulnerability in glioblastoma" (2021, Neuro-Oncology)
  • "3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma" (2023, Nature Communications)

Chavez frequently collaborates with a core group of researchers, including Owen Chapman, Jill P. Mesirov, Robert J. Wechsler-Reya, Sunita Sridhar, and Shanqing Wang. This network reflects a sustained partnership in advancing cancer biology and genomics understanding.

Their publications are predominantly featured in journals such as Neuro-Oncology, Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Cancer Discovery, and Nature Communications.

Best Publications

  • DNA methylation-based classification of central nervous system tumours

    David Capper;David Capper;David Capper;David T. W. Jones;Martin Sill;Volker Hovestadt

  • The landscape of genomic alterations across childhood cancers

    Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter

  • The whole-genome landscape of medulloblastoma subtypes

    Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Ivo Buchhalter;A. Sorana Morrissy;Volker Hovestadt

  • DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

    Felix Sahm;Felix Sahm;Daniel Schrimpf;Damian Stichel;David T.W. Jones

  • Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

    Pascal D. Johann;Pascal D. Johann;Serap Erkek;Marc Zapatka;Kornelius Kerl

  • Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

    Myunggon Ko;Jungeun An;Hozefa S. Bandukwala;Lukas Chavez

  • Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

    Sebastian M. Waszak;Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Giles W. Robinson

  • Active medulloblastoma enhancers reveal subgroup-specific cellular origins

    Charles Y. Lin;Charles Y. Lin;Serap Erkek;Yiai Tong;Linlin Yin

  • MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments

    Matthias Lienhard;Christina Grimm;Markus Morkel;Ralf Herwig

  • Large conserved domains of low DNA methylation maintained by Dnmt3a.

    Mira Jeong;Deqiang Sun;Min Luo;Yun Huang

  • Innate-like functions of natural killer T cell subsets result from highly divergent gene programs

    Isaac Engel;Grégory Seumois;Lukas Chavez;Daniela Samaniego-Castruita

  • Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

    Yun Huang;Lukas Chavez;Xing Chang;Xue Wang

  • Dynamic Changes in Chromatin Accessibility Occur in CD8+ T Cells Responding to Viral Infection

    James P. Scott-Browne;Isaac F. López-Moyado;Sara Trifari;Victor Wong

  • Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway

    Jason T. Huse;Matija Snuderl;David T. W. Jones;Carole D. Brathwaite

  • Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

    Tanvi Sharma;Tanvi Sharma;Edward C. Schwalbe;Edward C. Schwalbe;Daniel Williamson;Martin Sill

  • Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.

    Kristian W. Pajtler;Kristian W. Pajtler;Ji Wen;Martin Sill;Tong Lin

  • Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

    Zhen Dong;Guoxin Zhang;Meng Qu;Ryan C. Gimple;Ryan C. Gimple

  • Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.

    Pooja Panwalkar;Jonathan Clark;Vijay Ramaswamy;Debra Hawes

  • Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage

    Lukas Chavez;Justyna Jozefczuk;Christina Grimm;Jörn Dietrich

  • Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

    Stephen C. Mack;Kristian W. Pajtler;Kristian W. Pajtler;Lukas Chavez;Lukas Chavez;Konstantin Okonechnikov

Frequent Co-Authors

Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Marcel Kool
Marcel Kool German Cancer Research Center
David Capper
David Capper Charité - University Medicine Berlin
David T. W. Jones
David T. W. Jones German Cancer Research Center
Paul A. Northcott
Paul A. Northcott St. Jude Children's Research Hospital
Andrey Korshunov
Andrey Korshunov German Cancer Research Center
Anjana Rao
Anjana Rao La Jolla Institute For Allergy & Immunology
Peter Lichter
Peter Lichter German Cancer Research Center
Michael D. Taylor
Michael D. Taylor University of Toronto
Andreas von Deimling
Andreas von Deimling Heidelberg University

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