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Chemistry

D-Index
56
Citations
12105
World Ranking
11554
National Ranking
3120

Overview

Joseph M. Fox is affiliated with the University of Delaware in the United States. Their research spans multiple areas within chemistry and related fields, with a focus on organic chemistry and molecular biology. Their work intersects various disciplines including biochemistry, genetics, molecular biology, and medicine.

Fox's primary fields of study include:

  • Chemistry
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields Fox has contributed to are:

  • Organic Chemistry
  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Biomedical Engineering
  • Atomic and Molecular Physics, and Optics

The main topics of their research work involve:

  • Click Chemistry and Applications
  • Chemical Synthesis and Analysis
  • Monoclonal and Polyclonal Antibodies Research
  • Advanced biosensing and bioanalysis techniques
  • Synthesis and Catalytic Reactions
  • Molecular Junctions and Nanostructures
  • Radiopharmaceutical Chemistry and Applications

Their recent papers include:

  • Bioorthogonal chemistry, 2021, published in Nature Reviews Methods Primers
  • Enabling In Vivo Photocatalytic Activation of Rapid Bioorthogonal Chemistry by Repurposing Silicon-Rhodamine Fluorophores as Cytocompatible Far-Red Photocatalysts, 2021, Journal of the American Chemical Society
  • Catalytic Activation of Bioorthogonal Chemistry with Light (CABL) Enables Rapid, Spatiotemporally Controlled Labeling and No-Wash, Subcellular 3D-Patterning in Live Cells Using Long Wavelength Light, 2022, Journal of the American Chemical Society
  • Divergent Synthesis of Monosubstituted and Unsymmetrical 3,6-Disubstituted Tetrazines from Carboxylic Ester Precursors, 2020, Angewandte Chemie International Edition
  • Ligand-Directed Photocatalysts and Far-Red Light Enable Catalytic Bioorthogonal Uncaging inside Live Cells, 2023, Journal of the American Chemical Society

Frequent co-authors who have collaborated with Fox include:

  • Xinqiao Jia
  • He Zhang
  • Christopher W. am Ende
  • Hanyuan Gao
  • Zibo Li

Fox's research has been published predominantly in the following venues:

  • Journal of the American Chemical Society
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Applied Materials & Interfaces

Best Publications

  • Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.

    Melissa L. Blackman;Maksim Royzen;Joseph M. Fox

  • Genetic Encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions.

    Kathrin Lang;Lloyd Davis;Stephen Wallace;Mohan Mahesh

  • Highly Active and Selective Catalysts for the Formation of α-Aryl Ketones

    Joseph M. Fox;Xiaohua Huang;and André Chieffi;Stephen L. Buchwald

  • Bioorthogonal chemistry

    Unknown

  • Design and synthesis of highly reactive dienophiles for the tetrazine-trans-cyclooctene ligation.

    Michael T. Taylor;Melissa L. Blackman;Olga Dmitrenko;Joseph M. Fox

  • Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes.

    Jason L. Seitchik;Jennifer C. Peeler;Michael T. Taylor;Melissa L. Blackman

  • Diels-Alder cycloaddition for fluorophore targeting to specific proteins inside living cells.

    Daniel S. Liu;Anupong Tangpeerachaikul;Ramajeyam Selvaraj;Michael T. Taylor

  • Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation

    Ampofo Darko;Stephen Wallace;Olga Dmitrenko;Melodie M. Machovina

  • trans-Cyclooctene — a stable, voracious dienophile for bioorthogonal labeling

    Ramajeyam Selvaraj;Joseph M Fox

  • Synthesis, Self-Assembly, and Nonlinear Optical Properties of Conjugated Helical Metal Phthalocyanine Derivatives

    Joseph M. Fox;Thomas J. Katz;Sven Van Elshocht;Thierry Verbiest

  • A photochemical synthesis of functionalized trans-cyclooctenes driven by metal complexation.

    Maksim Royzen;Glenn P A Yap;Joseph M Fox

  • Catalytic asymmetric vinylation of ketone enolates.

    André Chieffi;Ken Kamikawa;Jens Åhman;Joseph M. Fox

  • Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes

    Zibo Li;Hancheng Cai;Matthew Hassink;Melissa L. Blackman

  • Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging.

    Heather E. Murrey;Joshua C. Judkins;Christopher W. am Ende;T. Eric Ballard

  • Chiral Crown Conformation of Rh2(S-PTTL)4: Enantioselective Cyclopropanation with α-Alkyl-α-diazoesters

    Andrew DeAngelis;Olga Dmitrenko;Glenn P. A. Yap;Joseph M. Fox

  • Rhodium(II)-catalyzed enantioselective C-H functionalization of indoles.

    Andrew DeAngelis;Valerie W. Shurtleff;Olga Dmitrenko;Joseph M. Fox

  • Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation

    Han Zhang;William S. Trout;Shuang Liu;Gabriel A. Andrade

  • Rh-Catalyzed Intermolecular Reactions of Alkynes with α-Diazoesters That Possess β-Hydrogens: Ligand-Based Control over Divergent Pathways

    Patricia Panne;Joseph M. Fox

  • Rh-Catalyzed Intermolecular Reactions of α-Alkyl-α-Diazo Carbonyl Compounds with Selectivity over β-Hydride Migration

    Andrew DeAngelis;Robert Panish;Joseph M. Fox

  • The Use of Catalytic Amounts of CuCl and Other Improvements in the Benzyne Route to Biphenyl‐Based Phosphine Ligands

    Steven Kaye;Joseph M. Fox;Joseph M. Fox;Frederick A. Hicks;Stephen L. Buchwald

  • Rhodium(II)-Catalyzed Enantioselective C-H Functionalizationof Indoles

    A. DeAngelis;V. W. Shurtleff;O. Dmitrenko;J. M. Fox

Frequent Co-Authors

Glenn P. A. Yap
Glenn P. A. Yap University of Delaware
Xinqiao Jia
Xinqiao Jia University of Delaware
Xiaoyuan Chen
Xiaoyuan Chen National University of Singapore
Thomas J. Katz
Thomas J. Katz Columbia University
Jason W. Chin
Jason W. Chin MRC Laboratory of Molecular Biology
Robert D. Bach
Robert D. Bach University of Delaware
David L. Burris
David L. Burris University of Delaware
Richard C. D. Brown
Richard C. D. Brown University of Southampton
Colin Thorpe
Colin Thorpe University of Delaware

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