World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
79
Citations
20773
World Ranking
3646
National Ranking
1173

Research.com Recognitions

  • 1941 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Internal medicine
  • Biochemistry

I.L. Chaikoff mostly deals with Internal medicine, Endocrinology, Biochemistry, Cholesterol and Metabolism. His work in the fields of Internal medicine, such as Thyroid, Blood chemistry and Weaning, overlaps with other areas such as Mechanism. Colloid and Iodine metabolism is closely connected to Trypsinization in his research, which is encompassed under the umbrella topic of Endocrinology.

In the subject of general Biochemistry, his work in Lipogenesis, In vitro, Enzyme and Fatty acid synthesis is often linked to Diabetic rat, thereby combining diverse domains of study. His Cholesterol research is multidisciplinary, relying on both Adrenal gland, Stomach, Endogeny and Fatty acid. His studies in Metabolism integrate themes in fields like Radioactive phosphorus, Respiration, Protein intake and Choline.

His most cited work include:

  • Plasma inorganic iodide as a homeostatic regulator of thyroid function. (426 citations)
  • Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths. (295 citations)
  • Extent and patterns of adaptation of enzyme activities in livers of normal rats fed diets high in glucose and fructose. (260 citations)

What are the main themes of his work throughout his whole career to date?

I.L. Chaikoff spends much of his time researching Internal medicine, Endocrinology, Biochemistry, Cholesterol and Thyroid. The concepts of his Internal medicine study are interwoven with issues in Fructose and Enzyme. In his research on the topic of Endocrinology, Iodine in biology is strongly related with Iodine.

His work carried out in the field of Biochemistry brings together such families of science as Radioactive phosphorus and Chromatography. His Cholesterol metabolism and Lipoprotein study in the realm of Cholesterol interacts with subjects such as Chylomicron and Chyle. His Metabolism study combines topics in areas such as Small intestine and Blood plasma.

He most often published in these fields:

  • Internal medicine (54.38%)
  • Endocrinology (54.08%)
  • Biochemistry (46.53%)

What were the highlights of his more recent work (between 1961-2008)?

  • Endocrinology (54.08%)
  • Internal medicine (54.38%)
  • Biochemistry (46.53%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Endocrinology, Internal medicine, Biochemistry, Cholesterol and Thyroid. His Endocrinology study deals with Iodine intersecting with Follicular phase. His research integrates issues of Organ culture and Trypsinization in his study of Internal medicine.

His research is interdisciplinary, bridging the disciplines of Chromatography and Biochemistry. His work on Sterol as part of general Cholesterol study is frequently connected to Chyle, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His research investigates the link between Thyroid and topics such as In vitro that cross with problems in Cofactor.

Between 1961 and 2008, his most popular works were:

  • Localization of the block in lipogenesis resulting from feeding fat. (116 citations)
  • Control of Lipid Metabolism in Hepatomas: Insensitivity of Rate of Fatty Acid and Cholesterol Synthesis by Mouse Hepatoma BW7756 to Fasting and to Feedback Control (105 citations)
  • Hydrogen transfer in fatty acid synthesis by rat liver and mammary-gland cell-free preparations studied with tritium-labelled pyridine nucleotides and glucose (84 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Internal medicine
  • Biochemistry

I.L. Chaikoff spends much of his time researching Biochemistry, Internal medicine, Endocrinology, Fatty acid and Cholesterol. His research combines Chromatography and Biochemistry. I.L. Chaikoff regularly ties together related areas like Fructose in his Internal medicine studies.

He has researched Endocrinology in several fields, including In vitro, Malate dehydrogenase and Pyruvic acid. His Fatty acid study combines topics from a wide range of disciplines, such as Carbon dioxide, Protein metabolism and Citric acid cycle. His study in the field of Sterol also crosses realms of Chylomicron, Chyle and Rabbit.

Best Publications

  • Plasma inorganic iodide as a homeostatic regulator of thyroid function.

    J. Wolff;I.L. Chaikoff

  • Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths.

    B. Bloom;I. L. Chaikoff;W. O. Reinhardt

  • Extent and patterns of adaptation of enzyme activities in livers of normal rats fed diets high in glucose and fructose.

    Walter M. Fitch;I.L. Chaikoff

  • The Extrahepatic Synthesis of Cholesterol

    Paul A. Srere;I.L. Chaikoff;S.S. Treitman;L.S. Burstein

  • Previous nutritional state and glucose conversion to fatty acids in liver slices.

    E.J. Masoro;I.L. Chaikoff;S.S. Chernick;J.M. Felts

  • Two blocks in carbohydrate utilization in the liver of the diabetic rat.

    S.S. Chernick;I.L. Chaikoff

  • The origin of cholesterol in liver, small intestine, adrenal gland, and testis of the rat: dietary versus endogenous contributions.

    M.D. Morris;I.L. Chaikoff

  • C14-CHOLESTEROL V. OBLIGATORY FUNCTION OF BILE IN INTESTINAL ABSORPTION OF CHOLESTEROL

    M. D. Siperstein;I. L. Chaikoff;W. O. Reinhardt

  • Conversion of fatty acids to carbohydrate; application of isotopes to this problem and role of the Krebs cycle as a synthetic pathway.

    E. O. Weinman;E. H. Strisower;I. L. Chaikoff

  • Glycolytic pathways and lipogenesis in mammary glands of lactating and nonlactating normal rats.

    S. Abraham;I.L. Chaikoff

  • Lipogenesis and glucose oxidation in the liver of the alloxan-diabetic rat.

    S.S. Chernick;I.L. Chaikoff;E.J. Masoro;Eugenia. Isaeff

  • Localization of the block in lipogenesis resulting from feeding fat.

    W. Bortz;S. Abraham;I.L. Chaikoff

  • Disposition of the cholesterol moiety of a chylomicron-containing lipoprotein fraction of chyle in the rat *

    W.J. Lossow;Nathan Brot;I.L. Chaikoff

  • Removal by the isolated rat liver of palmitate-1-C14 bound to albumin and of palmitate-1-C14 and cholesterol-4-C14 in chylomicrons from perfusion fluid.

    L.A. Hillyard;C.E. Cornelius;I.L. Chaikoff

  • Control of Lipid Metabolism in Hepatomas: Insensitivity of Rate of Fatty Acid and Cholesterol Synthesis by Mouse Hepatoma BW7756 to Fasting and to Feedback Control

    John R. Sabine;S. Abraham;I. L. Chaikoff

  • Site of formation of plasma phospholipides studied with C14-labeled palmitic acid.

    D.S. Goldman;I.L. Chaikoff;W.O. Reinhardt;C. Entenman

  • The nature of the circulating thyroid hormone.

    Alvin Taurog;I.L. Chaikoff

  • The Effect of Fructose Feeding on Glycolytic Enzyme Activities of the Normal Rat Liver

    Walter M. Fitch;R. Hill;I.L. Chaikoff

  • Significance of Endogenous Cholesterol in Arteriosclerosis: Synthesis in Arterial Tissue

    M. D. Siperstein;I. L. Chaikoff;S. S. Chernick

  • A new phospholipide-splitting enzyme specific for the ester linkage between the nitrogenous base and the phosphoric acid grouping.

    Donald J. Hanahan;I.L. Chaikoff

  • Lipogenesis from glucose in the normal and liverless animal as studied with C14-labeled glucose.

    E.J. Masoro;I.L. Chaikoff;W.G. Dauben

  • The In Vitro Conversion of C14-Labeled Glucose to Fatty Acids.∗

    S. S. Chernick;E. J. Masoro;I. L. Chaikoff

Frequent Co-Authors

William G. Dauben
William G. Dauben University of California, Berkeley
W. Z. Hassid
W. Z. Hassid University of California, Berkeley
Joseph Katz
Joseph Katz Johns Hopkins University
Paul A. Srere
Paul A. Srere The University of Texas Southwestern Medical Center

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