World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
16149
World Ranking
12359
National Ranking
5288

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cancer

Gilbert Jay mostly deals with Virology, Transgene, Virus, Molecular biology and Immunology. His Virology study incorporates themes from Carcinogenesis and Antigen. His Transgene research is multidisciplinary, relying on both Gene expression, Gene product, Regulator gene and Major histocompatibility complex.

His study in Virus is interdisciplinary in nature, drawing from both Cancer research, Neoplastic transformation, Sarcoma and Transforming virus. His work focuses on many connections between Molecular biology and other disciplines, such as 3T3 cells, that overlap with his field of interest in Heterologous, Leukemia, Confluency and Cell division. His Immunology research integrates issues from Genetically modified mouse and Amyloid precursor protein.

His most cited work include:

  • HBx gene of hepatitis B virus induces liver cancer in transgenic mice (1009 citations)
  • Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. (536 citations)
  • The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice (484 citations)

What are the main themes of his work throughout his whole career to date?

Gilbert Jay mainly focuses on Molecular biology, Gene, Antigen, Virology and Transgene. His Molecular biology research is multidisciplinary, incorporating elements of Cell culture, RNA, DNA, Cell biology and Regulation of gene expression. His study explores the link between Antigen and topics such as Immunoprecipitation that cross with problems in Epitope.

The various areas that Gilbert Jay examines in his Virology study include Gene product and Central nervous system. His Transgene research is mostly focused on the topic Genetically modified mouse. His Genetically modified mouse research focuses on subjects like Immunology, which are linked to Cancer research.

He most often published in these fields:

  • Molecular biology (46.23%)
  • Gene (26.42%)
  • Antigen (22.64%)

What were the highlights of his more recent work (between 1991-2016)?

  • Transgene (18.87%)
  • Molecular biology (46.23%)
  • Gene (26.42%)

In recent papers he was focusing on the following fields of study:

Gilbert Jay mainly investigates Transgene, Molecular biology, Gene, Genetically modified mouse and Cancer research. His Transgene research focuses on Cell biology and how it connects with Mammalian gene. The concepts of his Molecular biology study are interwoven with issues in MHC class I, Immune tolerance, Transfection and CD1.

His biological study spans a wide range of topics, including Virus, Virology, Cell culture and Pathology. His research investigates the link between Virus and topics such as Choroid plexus that cross with problems in Antigen. His Cancer research research incorporates elements of Carcinogenesis, Cancer and Prostate.

Between 1991 and 2016, his most popular works were:

  • The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice (484 citations)
  • Regulating gene expression in transgenic animals. (232 citations)
  • Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis. (148 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Cancer

His primary areas of investigation include Regulation of gene expression, Transgene, Molecular biology, Genetics and Gene expression. His Regulation of gene expression research includes themes of Transcriptional regulation, Transactivation, Liver cancer and HBx, Hepatitis B virus. His Transgene study combines topics in areas such as Apoptosis, Immunology, Amyloid precursor protein and Cell biology.

His studies deal with areas such as Natural killer T cell, Antigen-presenting cell, CD1, Natural killer cell and Immune tolerance as well as Molecular biology. His study with Major histocompatibility complex involves better knowledge in Gene. His studies in Gene integrate themes in fields like JC virus, Virology, Antigen and Choroid plexus.

Best Publications

  • HBx gene of hepatitis B virus induces liver cancer in transgenic mice

    Chang-Min Kim;Kazuhiko Koike;Izumu Saito;Tatsuo Miyamura

  • Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

    Albert B. Deleo;Gilbert Jay;Ettore Appella;Garrett C. Dubois

  • The Alzheimer's A Beta Peptide Induces Neurodegeneration and Apoptotic Cell Death in Transgenic Mice

    Frank M. LaFerla;Brad T. Tinkle;Charles J. Bieberich;Christian C. Haudenschild

  • The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

    M Nerenberg;SH Hinrichs;RK Reynolds;G Khoury

  • The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice.

    Jonathan Vogel;Steven Heye Hinrichs;Steven Heye Hinrichs;R. Kay Reynolds;Paul A. Luciw

  • Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice

    Jeffrey E. Green;Steven H. Hinrichs;Jonathan Vogel;Gilbert Jay

  • The released interleukin 2 receptor binds interleukin 2 efficiently.

    L A Rubin;G Jay;D L Nelson

  • Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene

    Kenichi Tanaka;Kurt J. Isselbacher;George Khoury;Gilbert Jay

  • A transgenic mouse model for human neurofibromatosis.

    SH Hinrichs;M Nerenberg;RK Reynolds;G Khoury

  • Regulating gene expression in transgenic animals.

    Catherine A. Kappel;Simon Xin-Min Zhang;Charles J. Bieberich;Gilbert Jay

  • Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry

    Mark C. Willingham;Gilbert Jay;Ira Pastan

  • Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice

    Claes Öhlén;Gunilla Kling;Petter Höglund;Mona Hansson

  • Neoplastic Transformation of Human Epidermal Keratinocytes by AD12-SV40 and Kirsten Sarcoma Viruses

    Johng S. Rhim;Gilbert Jay;Paul Arnstein;Floyd M. Price

  • The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

    R Pozzatti;J Vogel;G Jay

  • p53 transformation-related protein: detection by monoclonal antibody in mouse and human cells

    Wolfgang G. Dippold;Gilbert Jay;Albert B. DeLeo;George Khoury

  • Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.

    Young Do Yoo;Hiroyuki Ueda;Keunchil Park;Kathy C. Flanders

  • Identification of the SV40 agnogene product: a DNA binding protein.

    Gilbert Jay;Shigeko Nomura;Carl W. Anderson;George Khoury

  • Transgenic Mice Expressing a Truncated Form of the High Mobility Group I-C Protein Develop Adiposity and an Abnormally High Prevalence of Lipomas

    Paola Arlotta;Albert K.-F. Tai;Guidalberto Manfioletti;Charles Clifford

  • Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene

    Maria H. Johansson;Charles Bieberich;Gilbert Jay;Klas Kärre

  • The early region of human papovavirus JC induces dysmyelination in transgenic mice.

    Judy A. Small;Judy A. Small;George A. Scangos;Linda Cork;Gilbert Jay

Frequent Co-Authors

George Khoury
George Khoury National Institutes of Health
Petter Höglund
Petter Höglund Karolinska Institute
Kurt J. Isselbacher
Kurt J. Isselbacher Harvard University
Lloyd J. Old
Lloyd J. Old Ludwig Cancer Research
Klas Kärre
Klas Kärre Karolinska Institute
Ettore Appella
Ettore Appella National Institutes of Health
David L. Nelson
David L. Nelson Baylor College of Medicine
Paul A. Luciw
Paul A. Luciw University of California, Davis
Robert M. Friedman
Robert M. Friedman Oregon Health & Science University
Jonathan G. Seidman
Jonathan G. Seidman Harvard University

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