Frank A. Fitzpatrick

Overview

Best Publications

• Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

  J E Bleasdale;N R Thakur;R S Gremban;G L Bundy

  718
  Citations

• Cyclooxygenase-2 and carcinogenesis

  Stephen M. Prescott;F.A. Fitzpatrick

  716
  Citations

• Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro.

  F A Fitzpatrick;M A Wynalda

  434
  Citations

• Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of "epoxygenase"-derived eicosanoids.

  F A Fitzpatrick;R C Murphy

  376
  Citations

• Cyclooxygenase enzymes: regulation and function.

  F A Fitzpatrick

  355
  Citations

• Regulated formation of eicosanoids

  F.A. Fitzpatrick;Roy Soberman

  290
  Citations

• Erythrocyte-neutrophil interactions: formation of leukotriene B4 by transcellular biosynthesis.

  J E McGee;F A Fitzpatrick

  230
  Citations

• Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry.

  F A Fitzpatrick;M D Ennis;M E Baze;M A Wynalda

  205
  Citations

• Inflammation, carcinogenesis and cancer.

  F.A. Fitzpatrick

  202
  Citations

• Metabolism of leukotriene A4 by human erythrocytes. A novel cellular source of leukotriene B4.

  F Fitzpatrick;W Liggett;J McGee;S Bunting

  202
  Citations

• Electrophilic Prostaglandins and Lipid Aldehydes Repress Redox-sensitive Transcription Factors p53 and Hypoxia-inducible Factor by Impairing the Selenoprotein Thioredoxin Reductase

  Philip J. Moos;Kornelia Edes;Pamela Cassidy;Pamela Cassidy;Edmund Massuda

  192
  Citations

• Albumin stabilizes leukotriene A4.

  F A Fitzpatrick;D R Morton;M A Wynalda

  192
  Citations

• Triene prostaglandins: Prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances

  Mark O. Whitaker;Angela Wyche;Frank Fitzpatrick;Howard Sprecher

  187
  Citations

• Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes.

  J McGee;F Fitzpatrick

  185
  Citations

• Redox Signaling, Alkylation (Carbonylation) of Conserved Cysteines Inactivates Class I Histone Deacetylases 1, 2, and 3 and Antagonizes Their Transcriptional Repressor Function

  Kelly Doyle;Frank A. Fitzpatrick

  183
  Citations

• Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes.

  L Orning;G Krivi;F A Fitzpatrick

  173
  Citations

• Evaluation of a 7-Day Continuous Intravenous Infusion of Decitabine: Inhibition of Promoter-Specific and Global Genomic DNA Methylation

  Wolfram E. Samlowski;Sancy A. Leachman;Mark Wade;Pamela Cassidy

  170
  Citations

• Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase.

  Robert A. Lepley;Danny T. Muskardin;Frank A. Fitzpatrick

  169
  Citations

• Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis

  Philip J. Moos;F. A. Fitzpatrick

  163
  Citations

• 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.

  R A Lepley;F A Fitzpatrick

  160
  Citations