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Chemistry

D-Index
54
Citations
9154
World Ranking
12747
National Ranking
938

Overview

Florenz Sasse is affiliated with Technische Universität Braunschweig in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with an emphasis on Molecular Biology, Pharmacology, Toxicology, Organic Chemistry, and Epidemiology.

The scientist's work focuses on several key topics including:

  • Microbial Natural Products and Biosynthesis
  • Plant biochemistry and biosynthesis
  • Biochemical and Structural Characterization
  • Bioactive Compounds and Antitumor Agents
  • Medicinal Plants and Bioactive Compounds
  • Natural product bioactivities and synthesis
  • Synthesis and Biological Evaluation

Florenz Sasse's recent papers reflect a broad engagement with natural products and their biological activities. Some of the notable publications include:

  • Natural products targeting the elongation phase of eukaryotic protein biosynthesis, 2020, published in Natural Product Reports
  • Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade, 2022, published in Molecules
  • Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections, 2025, published in Cell Host & Microbe
  • Increasing the chances of finding novel antibiotics to manage multidrug-resistant pathogens, 2021, published in Kavaka

Frequent co-authors associated with Florenz Sasse's research include:

  • Mark Brönstrup
  • Saheed O. Anifowose
  • Wejdan S. AL-Qahtani
  • Badr Aldahmash
  • Maroua Jalouli

The scientist's publications appear in diverse venues such as:

  • Natural Product Reports
  • Molecules
  • Cell Host & Microbe
  • Kavaka

Best Publications

  • Complete genome sequence of the myxobacterium Sorangium cellulosum

    Susanne Schneiker;Olena Perlova;Olaf Kaiser;Klaus Gerth

  • Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties.

    Florenz Sasse;Heinrich Steinmetz;Jurgen Heil;Gerhard Hofle

  • Fungal endophytes and bioprospecting

    T.S. Suryanarayanan;N. Thirunavukkarasu;M.B. Govindarajulu;F. Sasse

  • New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.

    Ingo H. Hardt;Heinrich Steinmetz;Klaus Gerth;F. Sasse

  • Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria.

    Heinrich Steinmetz;Nicole Glaser;Eberhardt Herdtweck;Florenz Sasse

  • Antiviral drug discovery: broad-spectrum drugs from nature

    J. P. Martinez;F. Sasse;M. Brönstrup;J. Diez

  • Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties.

    Brigitte Kunze;Rolf Jansen;Florenz Sasse;Gerhard Höfle

  • Argyrin a reveals a critical role for the tumor suppressor protein p27kip1 in mediating antitumor activities in response to proteasome inhibition.

    Irina Nickeleit;Steffen Zender;Florenz Sasse;Robert Geffers

  • Mechanism of Action of Tubulysin, an Antimitotic Peptide from Myxobacteria

    Mohamed W. Khalil;Florenz Sasse;Heinrich Lünsdorf;Yasser A. Elnakady

  • Chondramides A~D, New Antifungal and Cytostatic Depsipeptides from Chondromyces crocatus(Myxobacteria)Production, Physico-chemical and Biological Properties

    Brigitte Kunze;Rolf Jansen;Florenz Sasse;Gerhard Höfle

  • Archazolid and apicularen : novel specific V-ATPase inhibitors

    Markus Huss;Florenz Sasse;Brigitte Kunze;Rolf Jansen

  • Archazolids, new cytotoxic macrolactones from Archangium gephyra (Myxobacteria). Production, isolation, physico-chemical and biological properties.

    Florenz Sasse;Heinrich Steinmetz;Gerhard Höfle;Hans Reichenbach

  • Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity.

    Axel Sandmann;Florenz Sasse;Rolf Müller

  • Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist

    Thomas A. Knappe;Florian Manzenrieder;Carlos Mas-Moruno;Uwe Linne

  • Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase

    A. Capell;S. Liebscher;K. Fellerer;N. Brouwers

  • The Chondramides: Cytostatic Agents From Myxobacteria Acting on the Actin Cytoskeleton

    Florenz Sasse;Brigitte Kunze;Thomas M. A. Gronewold;Hans Reichenbach

  • Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties.

    Florenz Sasse;Heinrich Steinmetz;Thomas Schupp;Frank Petersen

  • Semisynthesis and degradation of the tubulin inhibitors epothilone and tubulysin

    G. Höfle;N. Glaser;T. Leibold;U. Karama

  • Design, synthesis, and biological properties of highly potent tubulysin D analogues.

    Andrew W. Patterson;Hillary M. Peltier;Florenz Sasse;Jonathan A. Ellman

  • Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale.

    Mahmoud Fahmi Elsebai;Stefan Kehraus;Ulrike Lindequist;Florenz Sasse

  • Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties.

    Florenz Sasse;Heinrich Steinmetz;Gerhard Höfle;Hans Reichenbach

Frequent Co-Authors

Hans Reichenbach
Hans Reichenbach University of California, Los Angeles
Gerhard Höfle
Gerhard Höfle Helmholtz Centre for Infection Research
Andreas Kirschning
Andreas Kirschning University of Hannover
Rolf Jansen
Rolf Jansen Helmholtz Centre for Infection Research
Martin E. Maier
Martin E. Maier University of Tübingen
Rolf Müller
Rolf Müller Saarland University
Andreas Meyerhans
Andreas Meyerhans Pompeu Fabra University
Claus Jacob
Claus Jacob Saarland University
Klaus Gerth
Klaus Gerth Helmholtz Centre for Infection Research
Ronald Frank
Ronald Frank Rutgers, The State University of New Jersey

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