D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 70 Citations 15,942 256 World Ranking 3559 National Ranking 297

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Enzyme
  • Biochemistry

Biochemistry, Stereochemistry, Myxobacteria, Biological activity and Sorangium cellulosum are his primary areas of study. Staphylococcus aureus is closely connected to Strain in his research, which is encompassed under the umbrella topic of Biochemistry. His Stereochemistry research is multidisciplinary, incorporating elements of Isolation and Biosynthesis.

His Myxobacteria research integrates issues from Peptide, Antifungal, Microbiology and In vitro. His Biological activity research incorporates themes from Myxococcus, MTT assay, Cell growth and Fermentation. Gerhard Höfle has included themes like Bacterial gliding, Antibiotics, Ether, Oxazole and Streptomyces in his Sorangium cellulosum study.

His most cited work include:

  • 4‐Dialkylaminopyridines as Highly Active Acylation Catalysts. [New synthetic method (25)] (859 citations)
  • Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. (540 citations)
  • Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution† (437 citations)

What are the main themes of his work throughout his whole career to date?

Gerhard Höfle focuses on Stereochemistry, Myxobacteria, Biochemistry, Sorangium cellulosum and Bacterial gliding. His study looks at the relationship between Stereochemistry and topics such as Biosynthesis, which overlap with Methionine. His study explores the link between Myxobacteria and topics such as Antibiotics that cross with problems in Isolation.

His work on Gene cluster expands to the thematically related Biochemistry. Gerhard Höfle interconnects Metabolite and Organic chemistry in the investigation of issues within Sorangium cellulosum. Gerhard Höfle combines subjects such as Combinatorial chemistry, Epothilones and Thiazole with his study of Epothilone.

He most often published in these fields:

  • Stereochemistry (56.62%)
  • Myxobacteria (22.79%)
  • Biochemistry (20.96%)

What were the highlights of his more recent work (between 2001-2016)?

  • Stereochemistry (56.62%)
  • Myxobacteria (22.79%)
  • Biochemistry (20.96%)

In recent papers he was focusing on the following fields of study:

Gerhard Höfle mainly investigates Stereochemistry, Myxobacteria, Biochemistry, Biosynthesis and Sorangium cellulosum. His Stereochemistry research incorporates elements of Biological activity, Stigmatella aurantiaca and Polyketide. The concepts of his Myxobacteria study are interwoven with issues in Amino acid, Fermentation, Two-dimensional nuclear magnetic resonance spectroscopy, Combinatorial chemistry and Bacterial gliding.

His study in Gene cluster extends to Biochemistry with its themes. He has researched Biosynthesis in several fields, including Natural product, Quinoline and Terpenoid. His biological study spans a wide range of topics, including Derivative, Cytotoxic T cell, Ring and Gram-positive bacteria.

Between 2001 and 2016, his most popular works were:

  • The Biosynthesis of the Aromatic Myxobacterial Electron Transport Inhibitor Stigmatellin Is Directed by a Novel Type of Modular Polyketide Synthase (162 citations)
  • Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria. (128 citations)
  • Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis. (103 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Enzyme
  • Biochemistry

Gerhard Höfle mainly focuses on Stereochemistry, Biochemistry, Myxobacteria, Sorangium cellulosum and Biological activity. The Stereochemistry study combines topics in areas such as Stigmatella aurantiaca and Amide. Biochemistry is closely attributed to Antimicrobial in his study.

His studies deal with areas such as Fermentation, Lactone and Microbiology as well as Myxobacteria. His research in Sorangium cellulosum intersects with topics in Apoptosis, Cell cycle and Epothilones. His Biological activity research is multidisciplinary, incorporating perspectives in Pyrrole, Ring, Oxazoline, Myxobacterales and Leupyrrin A1.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

4-Dialkylaminopyridines as Highly Active Acylation Catalysts. [New synthetic method (25)]

Gerhard Höfle;Wolfgang Steglich;Helmut Vorbrüggen.
Angewandte Chemie (1978)

1502 Citations

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties.

Klaus Gerth;Norbert Bedorf;Gerhard Höfle;Herbert Irschik.
The Journal of Antibiotics (1996)

872 Citations

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution†

Gerhard Höfle;Norbert Bedorf;Heinrich Steinmetz;Dietmar Schomburg.
Angewandte Chemie (1996)

683 Citations

4‐Dialkylaminopyridine als hochwirksame Acylierungskatalysatoren

Gerhard Höfle;Wolfgang Steglich;Helmut Vorbrüggen.
Angewandte Chemie (1978)

578 Citations

Nucleoside Syntheses, XXIII1) On the Mechanism of Nucleoside Synthesis

Helmut Vorbrüggen;Gerhard Höfle.
Chemische Berichte (1981)

388 Citations

Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties.

Florenz Sasse;Heinrich Steinmetz;Jurgen Heil;Gerhard Hofle.
The Journal of Antibiotics (2000)

350 Citations

New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.

Barbara Silakowski;Hans Ulrich Schairer;Heidi Ehret;Brigitte Kunze.
Journal of Biological Chemistry (1999)

337 Citations

Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase.

Thorsten Friedrich;Petra Van Heek;Hans Leif;Tomoko Ohnishi.
FEBS Journal (1994)

335 Citations

4‐Dimethylamino‐pyridin, ein hochwirksamer Acylierungskatalysator

W. Steglich;G. Höfle.
Angewandte Chemie (1969)

277 Citations

The Biosynthesis of the Aromatic Myxobacterial Electron Transport Inhibitor Stigmatellin Is Directed by a Novel Type of Modular Polyketide Synthase

Nikolaos Gaitatzis;Barbara Silakowski;Brigitte Kunze;Gabriele Nordsiek.
Journal of Biological Chemistry (2002)

258 Citations

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