World's Best Scientists 2026 revealed!
Award Badge
Neuroscience
Netherlands
2026

D-Index & Metrics

Neuroscience

D-Index
147
Citations
80995
World Ranking
160
National Ranking
3

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Netherlands Leader Award
  • 2025 - Research.com Neuroscience in Netherlands Leader Award

Overview

E.R. de Kloet is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the fields of neuroscience and medicine, with a significant focus on behavioral neuroscience, endocrinology, diabetes and metabolism, social psychology, clinical psychology, and biological psychiatry.

The scientist's research topics cover several areas related to stress and hormonal regulation. These include:

  • Stress Responses and Cortisol
  • Hormonal Regulation and Hypertension
  • Neuroendocrine regulation and behavior
  • Tryptophan and brain disorders
  • Circadian rhythm and melatonin
  • Maternal Mental Health During Pregnancy and Postpartum
  • Child and Adolescent Psychosocial and Emotional Development

E.R. de Kloet has contributed publications to multiple venues, with frequent appearances in:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Psychoneuroendocrinology
  • Archives of Veterinary Science and Medicine
  • Molecular Neurobiology
  • Molecular Psychiatry

Selected recent papers authored or coauthored by E.R. de Kloet include:

  • "The cortisol switch between vulnerability and resilience" (2023), published in Molecular Psychiatry
  • "Forced swim stressor: Trends in usage and mechanistic consideration" (2021), published in European Journal of Neuroscience
  • "Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress" (2020), published in Scientific Reports
  • "Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy" (2022), published in Neurobiology of Stress
  • "Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases" (2020), published in International Journal of Molecular Sciences

E.R. de Kloet often collaborates with several researchers, including:

  • Onno C. Meijer
  • Marc Molendijk
  • Alejandro F. De Nicola
  • María Meyer
  • Megan Galbally

Best Publications

  • Stress and the brain: from adaptation to disease

    E. Ron de Kloet;Marian Joëls;Florian Holsboer

  • Brain corticosteroid receptor balance in health and disease.

    E R De Kloet;E Vreugdenhil;M S Oitzl;M Joëls

  • Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

    J. M. H. M. Reul;E. R. De Kloet

  • Stress and cognition: are corticosteroids good or bad guys?

    E. Ron de Kloet;Melly S. Oitzl;Marian Joëls

  • Adrenal steroid receptors and actions in the nervous system

    B. S. McEwen;E. R. De Kloet;W. Rostene

  • LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

    C.R.W. Edwards;D. Burt;M.A. Mcintyre;E.R. De Kloet

  • Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to …

    Unknown

  • Brain corticosteroid receptor balance and homeostatic control

    Unknown

  • Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.

    M S Oitzl;E R de Kloet

  • Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems

    E.R. De Kloet;J.M.H.M. Reul

  • The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.

    Nikolaos P. Daskalakis;Nikolaos P. Daskalakis;Nikolaos P. Daskalakis;Rosemary C. Bagot;Rosemary C. Bagot;Karen J. Parker;Christiaan H. Vinkers

  • Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress

    Danielle L. Champagne;Rosemary C. Bagot;Felisa van Hasselt;Ger Ramakers

  • Differences in corticosterone and dexamethasone binding to rat brain and pituitary

    Ronald De Kloet;Gislaine Wallach;Bruce S. McEWEN

  • On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation.

    Anna Ratka;Winardi Sutanto;Margreet Bloemers;Ronald de Kloet

  • The coming out of the brain mineralocorticoid receptor

    Marian Joëls;Henk Karst;Roel DeRijk;E. Ronald de Kloet

  • The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

    Henrik Oster;Etienne Challet;Volker Ott;Emanuela Arvat

  • Do corticosteroids damage the brain

    J. Herbert;I. M. Goodyer;A. B. Grossman;M. H. Hastings

  • Control of neuronal excitability by corticosteroid hormones.

    Marian Joëls;E.Ronald de Kloet

  • Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

    M. Joëls;E.R. de Kloet

  • Corticosteroid hormones in the central stress response: quick-and-slow.

    E. Ronald de Kloet;Henk Karst;Marian Joëls

  • The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat.

    M P Carey;C H Deterd;J de Koning;F Helmerhorst

  • Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome.

    E N Griep;J W Boersma;E R de Kloet

  • Effects of Glucocorticoids and Norepinephrine on the Excitability in the Hippocampus

    M Joels;ER de Kloet

  • Cellular Localization of Interleukin 6 mRNA and Interleukin 6 Receptor mRNA in Rat Brain

    B. Schöbitz;E. R. de Kloet;W. Sutanto;F. Holsboer

  • Stress, genes and the mechanism of programming the brain for later life.

    E. Ronald de Kloet;Rosana M. Sibug;Frans M. Helmerhorst;Mathias Schmidt

  • Brain development under stress: hypotheses of glucocorticoid actions revisited.

    Melly S. Oitzl;Danielle L. Champagne;Rixt van der Veen;E. Ronald de Kloet

  • Penetration of Dexamethasone into Brain Glucocorticoid Targets Is Enhanced in mdr1A P-Glycoprotein Knockout Mice

    O. C. Meijer;E. C. M. de Lange;D. D. Breimer;A. G. de Boer

  • Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus.

    J. A. M. Van Eekelen;W. Jiang;E. R. De Kloet;M. C. Bohn

  • Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications.

    J. M. H. M. Reul;F. R. van den Bosch;E. R. de Kloet

  • Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain.

    B. Schöbitz;E. R. de Kloet;F. Holsboer

  • Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis.

    J.M.H.M. Reul;E.R. De Kloet

Frequent Co-Authors

Melly S. Oitzl
Melly S. Oitzl University of Amsterdam
Marian Joëls
Marian Joëls University of Groningen
Onno C. Meijer
Onno C. Meijer Leiden University Medical Center
Dirk H.G. Versteeg
Dirk H.G. Versteeg Utrecht University
Marianne B. Müller
Marianne B. Müller Johannes Gutenberg University of Mainz
Henk Karst
Henk Karst Utrecht University
Paul J. Lucassen
Paul J. Lucassen University of Amsterdam
Gábor L. Kovács
Gábor L. Kovács University of Pecs
Frans G. Zitman
Frans G. Zitman Leiden University
E.J.C. de Geus
E.J.C. de Geus Vrije Universiteit Amsterdam

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring neuroscience in the USA opens doors to diverse career paths, many of which intersect with psychology, counseling, and therapy. For those interested in supporting mental health, there are several online degree options that can complement neuroscience studies or serve as alternative pathways.

Accredited programs such as the cacrep counseling programs ensure high educational standards and can prepare you for professional licensure. If affordability is important, you might consider a respected online counseling degree, which offers flexibility and accessibility for diverse learners.

Students interested in family dynamics or relationship-oriented careers can explore family therapy degree programs, which focus on evidence-based approaches to counseling couples and families. Additionally, pursuing a master in psychology online can be a strong choice for those seeking to deepen their understanding of the human mind and prepare for advanced roles.

These related degrees provide valuable skills and knowledge, expanding professional opportunities in both clinical and research settings connected to neuroscience.

Best Scientists Citing E.R. de Kloet

Trending Scientists

Recently Published Articles