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Microbiology

D-Index
71
Citations
15354
World Ranking
1877
National Ranking
795

Overview

Donald W. MacGlashan is a researcher affiliated with Johns Hopkins University in the United States, specializing primarily in Medicine and Immunology and Microbiology. Their work encompasses several interconnected subfields including Immunology, Immunology and Allergy, Rheumatology, Genetics, and Physiology.

The scientist has contributed extensively to topics related to allergy and immunological responses. The main areas of focus include:

  • Mast cells and histamine
  • Food Allergy and Anaphylaxis Research
  • Urticaria and Related Conditions
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Asthma and respiratory diseases
  • Drug-Induced Adverse Reactions
  • Allergic Rhinitis and Sensitization

Among recent publications, the following papers feature prominently:

  • Response of peripheral blood basophils in subjects with chronic spontaneous urticaria during treatment with omalizumab, 2021, Journal of Allergy and Clinical Immunology
  • The efficacy of omalizumab treatment in chronic spontaneous urticaria is associated with basophil phenotypes, 2021, Journal of Allergy and Clinical Immunology
  • Targeting the FcεRI Pathway as a Potential Strategy to Prevent Food-Induced Anaphylaxis, 2020, Frontiers in Immunology
  • A phase II study of Bruton's tyrosine kinase inhibition for the prevention of anaphylaxis, 2023, Journal of Clinical Investigation
  • Vancomycin immediate skin responses in vancomycin-naïve subjects, 2021, Clinical & Experimental Allergy

Donald W. MacGlashan frequently collaborates with a core group of researchers, which includes:

  • Melanie C. Dispenza
  • John T. Schroeder
  • Kristin Chichester
  • Santiago Alvarez-Arango
  • Bruce S. Bochner

The majority of Donald W. MacGlashan's publications appear in established journals such as:

  • Journal of Allergy and Clinical Immunology (11 publications)
  • Clinical & Experimental Allergy (5 publications)
  • Frontiers in Immunology (2 publications)
  • Journal of Clinical Investigation (1 publication)
  • Methods in molecular biology (1 publication)

The research contributions of Donald W. MacGlashan include work on cellular mechanisms underlying allergic diseases, with particular attention to basophil function and mediator release in conditions like chronic spontaneous urticaria. This includes investigations into the effects of omalizumab treatment and approaches targeting immune pathways to prevent anaphylaxis. Their work spans both clinical and experimental domains within allergy and immunology.

Best Publications

  • Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody.

    Donald W. MacGlashan;Bruce S. Bochner;Daniel C. Adelman;Paula M. Jardieu

  • Omalizumab-induced reductions in mast cell FcεRI expression and function

    Lisa A. Beck;Gregory V. Marcotte;Donald MacGlashan;Alkis Togias

  • The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils.

    Michele Columbo;Edward M. Horowitz;Luis M. Botana;Donald W. MacGlashan

  • Prostaglandin-Induced Activation of Nociceptive Neurons via Direct Interaction with Transient Receptor Potential A1 (TRPA1)

    Thomas E. Taylor-Clark;Bradley J. Undem;Donald W. MacGlashan;Srinivas Ghatta

  • Generation of leukotrienes by purified human lung mast cells.

    D W MacGlashan;R P Schleimer;S P Peters;E S Schulman

  • Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells.

    R P Schleimer;E S Schulman;D W MacGlashan;S P Peters

  • Secretion of IL-4 from human basophils. The relationship between IL-4 mRNA and protein in resting and stimulated basophils.

    Donald MacGlashan;Jane M. White;Shau Ku Huang;Santa J. Ono

  • Arachidonic acid metabolism in purified human lung mast cells.

    S P Peters;D W MacGlashan;E S Schulman;R P Schleimer

  • Human lung mast cells: purification and characterization.

    E S Schulman;D W MacGlashan;S P Peters;R P Schleimer

  • Down-Regulation of Human Basophil IgE and FCεRIα Surface Densities and Mediator Release by Anti-IgE-Infusions Is Reversible In Vitro and In Vivo

    Sarbjit S. Saini;Donald W. Macglashan;Sherry A. Sterbinsky;Alkis Togias

  • Histamine: A mediator of inflammation.

    Donald MacGlashan

  • Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes

    D. MacGlashan

  • Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate.

    P T Peachell;D W MacGlashan;L M Lichtenstein;R P Schleimer

  • Diagnostic Tests Based on Human Basophils: Potentials, Pitfalls and Perspectives

    Jörg Kleine-Tebbe;Stephan Erdmann;Edward F. Knol;Donald W. MacGlashan

  • IgE-dependent IL-4 secretion by human basophils. The relationship between cytokine production and histamine release in mixed leukocyte cultures.

    John T. Schroeder;Donald W. MacGlashan;Anne Kagey-Sobotka;Jane M. White

  • In vitro regulation of FcεRIα expression on human basophils by IgE antibody

    Donald MacGlashan;Jane McKenzie-White;Kristine Chichester;Bruce S. Bochner

  • Regulation of human basophil mediator release by cytokines. I. Interaction with antiinflammatory steroids.

    R P Schleimer;C P Derse;B Friedman;S Gillis

  • Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy

    Jessica H. Savage;Jean Paul Courneya;Patricia M. Sterba;Donald W. Macglashan

  • Heterogeneity of human mast cells

    E S Schulman;A Kagey-Sobotka;D W MacGlashan;N F Adkinson

  • Characterization of inflammatory mediator release from purified human lung mast cells

    R. P. Schleimer;D. W. Macglashan;S. P. Peters;R. N. Pinckard

Frequent Co-Authors

Lawrence M. Lichtenstein
Lawrence M. Lichtenstein Johns Hopkins University
Robert P. Schleimer
Robert P. Schleimer Northwestern University
Sarbjit S. Saini
Sarbjit S. Saini Johns Hopkins University
Bruce S. Bochner
Bruce S. Bochner Northwestern University
John T. Schroeder
John T. Schroeder Johns Hopkins University
Anne Kagey-Sobotka
Anne Kagey-Sobotka Johns Hopkins University
Jane Warner
Jane Warner University of Southampton
Ann M. Dvorak
Ann M. Dvorak Beth Israel Deaconess Medical Center
Robert G. Hamilton
Robert G. Hamilton Johns Hopkins University School of Medicine
Robert M. Naclerio
Robert M. Naclerio University of Chicago

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