World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
162
Citations
137708
World Ranking
110
National Ranking
84

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

Darwin J. Prockop mainly investigates Biochemistry, Hydroxyproline, Proline, Protocollagen and Hydroxylation. His studies deal with areas such as Covalent bond and Antigen as well as Biochemistry. His Hydroxyproline study combines topics in areas such as Collagen biosynthesis, Intracellular and Incubation.

His Proline research is multidisciplinary, incorporating elements of Extracellular, Secretion and Lysine. Much of his study explores Protocollagen relationship to Stereochemistry. His Enzyme study combines topics from a wide range of disciplines, such as Chromatography and Agarose.

His most cited work include:

  • Modified procedure for the assay of H3- or C14-labeled hydroxyproline (619 citations)
  • Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon (256 citations)
  • The Biosynthesis of Collagen: (Second of Three Parts) (208 citations)

What are the main themes of his work throughout his whole career to date?

Darwin J. Prockop focuses on Biochemistry, Proline, Hydroxyproline, Hydroxylation and Protocollagen. His study in Enzyme, Lysine, Hydroxylysine, Biosynthesis and In vitro is done as part of Biochemistry. His studies in Proline integrate themes in fields like Extracellular, Extracellular matrix, Intracellular and Incubation.

His Hydroxyproline research integrates issues from Amino acid, Stereochemistry, Cartilage and Metabolism. The various areas that Darwin J. Prockop examines in his Hydroxylation study include Puromycin and Peptide. His Protocollagen research is multidisciplinary, incorporating perspectives in Golgi apparatus, Endoplasmic reticulum and Vacuole.

He most often published in these fields:

  • Biochemistry (72.50%)
  • Proline (52.50%)
  • Hydroxyproline (51.25%)

What were the highlights of his more recent work (between 1973-2015)?

  • Gene (7.50%)
  • Genetics (6.25%)
  • Molecular biology (11.25%)

In recent papers he was focusing on the following fields of study:

His main research concerns Gene, Genetics, Molecular biology, Mutation and Procollagen peptidase. Darwin J. Prockop has included themes like Glutamine, Cartilage and Function in his Gene study. In general Genetics study, his work on Exon, Genetic determinism, Genetic predisposition and Mutant often relates to the realm of Structural Protein Gene, thereby connecting several areas of interest.

Darwin J. Prockop focuses mostly in the field of Molecular biology, narrowing it down to topics relating to Allele and, in certain cases, Residue, Tryptophan and Arginine. His Mutation research incorporates elements of Nucleic acid, Polymorphism, Genetic linkage, Restriction fragment length polymorphism and Linkage. His work deals with themes such as Protocollagen, Hydroxylation, Golgi apparatus, Endoplasmic reticulum and Cell fractionation, which intersect with Procollagen peptidase.

Between 1973 and 2015, his most popular works were:

  • Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes. (188 citations)
  • Two improved methods for preparing ferritin-protein conjugates for electron microscopy. (142 citations)
  • A second mutation in the type II procollagen gene (COL2AI) causing stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon. (92 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Biochemistry

His primary areas of investigation include Exon, Gene, Genetics, Phenotype and Osteochondrodysplasia. His research in Exon intersects with topics in Gene mutation, Procollagen peptidase, Molecular biology, Allele and Gene duplication. Darwin J. Prockop studies Gene, namely Mutation.

The concepts of his Phenotype study are interwoven with issues in Genetic determinism and Genotype.

Best Publications

  • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

    M. Dominici;K. Le Blanc;I. Mueller;I. Slaper-Cortenbach

  • Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues

    Darwin J. Prockop

  • Adult rat and human bone marrow stromal cells differentiate into neurons

    Dale Woodbury;Emily J. Schwarz;Darwin J. Prockop;Ira B. Black

  • Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains

    Gene C. Kopen;Darwin J. Prockop;Donald G. Phinney

  • Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta

    Edwin M. Horwitz;Darwin J. Prockop;Lorraine A. Fitzpatrick;Winston W. K. Koo

  • Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.

    Donald G. Phinney;Darwin J. Prockop

  • Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

    Ryang Hwa Lee;Andrey A Pulin;Min Jeong Seo;Daniel J. Kota;Daniel J. Kota

  • COLLAGENS: Molecular Biology, Diseases, and Potentials for Therapy

    Darwin J. Prockop;Kari I. Kivirikko

  • An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.

    Carl A Gregory;W Grady Gunn;Alexandra Peister;Darwin J Prockop

  • Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow.

    David C. Colter;Reiner Class;Carla M. DiGirolamo;Darwin J. Prockop

  • Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats—similarities to astrocyte grafts

    Azizi Sa;Stokes D;Augelli Bj;DiGirolamo C

  • Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery

    C. P. Hofstetter;E. J. Schwarz;D. Hess;J. Widenfalk

  • Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential

    Alexandra Peister;Jason A. Mellad;Jason A. Mellad;Benjamin L. Larson;Benjamin L. Larson;Brett M. Hall;Brett M. Hall

  • Modifications of a specific assay for hydroxyproline in urine

    Kari I. Kivirikko;Ossi Laitinen;Darwin J. Prockop

  • A specific method for the analysis of hydroxyproline in tissues and urine.

    Darwin J. Prockop;Sidney Udenfriend

  • Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality

    Ichiro Sekiya;Benjamin L. Larson;Jason R. Smith;Radhika Pochampally

  • Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice

    R F Pereira;K W Halford;M D O'Hara;D B Leeper

  • Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells.

    David C. Colter;Ichiro Sekiya;Darwin J. Prockop

  • Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate.

    Carla M. DiGirolamo;David Stokes;David Colter;Donald G. Phinney

  • Mitochondrial transfer between cells can rescue aerobic respiration

    Jeffrey L. Spees;Scott D. Olson;Mandolin J. Whitney;Darwin J. Prockop

Frequent Co-Authors

Joel Rosenbloom
Joel Rosenbloom Thomas Jefferson University
Joseph M. Lane
Joseph M. Lane Hospital for Special Surgery
Björn Olsen
Björn Olsen Harvard University
David E Pleasure
David E Pleasure University of California, Davis
Sergio A. Jimenez
Sergio A. Jimenez Thomas Jefferson University
Nicholas A. Kefalides
Nicholas A. Kefalides University of Pennsylvania
Kari I. Kivirikko
Kari I. Kivirikko University of Oulu
Matthew L. Warman
Matthew L. Warman Boston Children's Hospital
Elaine H. Zackai
Elaine H. Zackai Children's Hospital of Philadelphia
Han G. Brunner
Han G. Brunner Radboud University

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