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Biology and Biochemistry

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Overview

Dagan Wells is affiliated with John Radcliffe Hospital in the United Kingdom and has published extensively in the fields of medicine, biochemistry, genetics, and molecular biology. Their research focuses primarily on reproductive biology, prenatal screening, and molecular genetics, with particular attention to assisted reproductive technologies and genetic engineering methods.

Their recent publications include the following papers:

  • Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues, 2020, Fertility and Sterility
  • Frequent loss of heterozygosity in CRISPR-Cas9-edited early human embryos, 2021, Proceedings of the National Academy of Sciences
  • PGDIS position statement on the transfer of mosaic embryos 2021, 2022, Reproductive BioMedicine Online
  • ESHRE survey results and good practice recommendations on managing chromosomal mosaicism, 2022, Human Reproduction Open
  • First pilot study of maternal spindle transfer for the treatment of repeated in vitro fertilization failures in couples with idiopathic infertility, 2023, Fertility and Sterility

Wells has collaborated frequently with Katharina Späth, Nada Kubikova, Kishlay Kumar, Marga Esbert, and Marta Venturas.

The scientist has contributed numerous articles in several publication venues, with notable frequencies in:

  • Human Reproduction
  • Fertility and Sterility
  • Reproductive BioMedicine Online
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences

Their main fields of study consist of Medicine and Biochemistry, Genetics, and Molecular Biology. Subfields include Molecular Biology, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health, Genetics, and Immunology.

The core topics addressed in their body of work include:

  • Prenatal Screening and Diagnostics
  • Reproductive Biology and Fertility
  • CRISPR and Genetic Engineering
  • Reproductive System and Pregnancy
  • Assisted Reproductive Technology and Twin Pregnancy
  • Mitochondrial Function and Pathology
  • Pluripotent Stem Cells Research

Best Publications

  • Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization

    Dagan Wells;Joy D.A. Delhanty

  • Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.

    Santiago Munné;Brian Kaplan;John L. Frattarelli;Tim Child

  • The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender

    Samer Alfarawati;Elpida Fragouli;Pere Colls;John Stevens

  • Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation

    Dagan Wells;Jon K. Sherlock;Alan H. Handyside;Joy D. A. Delhanty

  • Clinical application of comprehensive chromosomal screening at the blastocyst stage

    William B. Schoolcraft;Elpida Fragouli;John Stevens;Santiago Munne

  • Genome editing reveals a role for OCT4 in human embryogenesis

    Norah M. E. Fogarty;Afshan McCarthy;Kirsten E. Snijders;Benjamin E. Powell

  • Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos

    Cristina Gutiérrez-Mateo;Pere Colls;Jorge Sánchez-García;Tomas Escudero

  • Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization

    Gary L. Harton;Santiago Munné;Mark Surrey;Jamie Grifo

  • The origin and impact of embryonic aneuploidy

    Elpida Fragouli;Samer Alfarawati;Katharina Spath;Souraya Jaroudi

  • Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential

    Elpida Fragouli;Katharina Spath;Samer Alfarawati;Fiona Kaper

  • Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation

    Elpida Fragouli;Samer Alfarawati;Danny D. Daphnis;N-neka Goodall

  • Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

    Louise A. Hyslop;Paul Blakeley;Lyndsey Craven;Jessica Richardson

  • Live birth derived from oocyte spindle transfer to prevent mitochondrial disease

    John Zhang;Hui Liu;Shiyu Luo;Zhuo Lu

  • Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.

    Santiago Munné;Joshua Blazek;Michael Large;Pedro A. Martinez-Ortiz

  • First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.

    Dagan Wells;Dagan Wells;Tomas Escudero;Brynn Levy;Kurt Hirschhorn

  • Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid–aneuploid blastocysts

    Elpida Fragouli;Samer Alfarawati;Katharina Spath;Dhruti Babariya

  • Clinical utilisation of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation

    Dagan Wells;Kulvinder Kaur;Jamie A. Grifo;Michael Glassner

  • Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates

    Jacques Cohen;Dagan Wells;Santiago Munné

  • Comprehensive molecular cytogenetic analysis of the human blastocyst stage

    E. Fragouli;M. Lenzi;R. Ross;M. Katz-Jaffe

  • The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome.

    Zhongwei Huang;Dagan Wells

Frequent Co-Authors

Santiago Munné
Santiago Munné Saint Barnabas Medical Center
Joy D. A. Delhanty
Joy D. A. Delhanty University College London
Jacques Cohen
Jacques Cohen Reprogenetics
David E. Williams
David E. Williams University of Auckland
Joanna Poulton
Joanna Poulton University of Oxford
Darren K. Griffin
Darren K. Griffin University of Kent
Sherman J. Silber
Sherman J. Silber Mount Sinai Morningside
Chris Jones
Chris Jones Institute of Cancer Research
Sunil R. Lakhani
Sunil R. Lakhani University of Queensland
John Parrington
John Parrington University of Oxford

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