World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
18914
World Ranking
5617
National Ranking
2667

Overview

Denny Sakkas is affiliated with Yale University in the United States and has contributed extensively to the field of medicine, with a focus on reproductive health and related disciplines. Their research spans multiple subfields including Pediatrics, Perinatology and Child Health, Reproductive Medicine, Public Health, Environmental and Occupational Health, Molecular Biology, and Obstetrics and Gynecology.

Their work covers several key topics within reproductive biology and fertility, highlighting areas such as Assisted Reproductive Technology and Twin Pregnancy, Reproductive Health and Technologies, Prenatal Screening and Diagnostics, Ovarian Function and Disorders, Sperm and Testicular Function, and also extends into Renal and related cancers.

Below are some of the recent papers authored or co-authored by Denny Sakkas:

  • Multicenter prospective study of concordance between embryonic cell-free DNA and trophectoderm biopsies from 1301 human blastocysts, 2020, American Journal of Obstetrics and Gynecology
  • DNA fragmentation of sperm: a radical examination of the contribution of oxidative stress and age in 16,945 semen samples, 2020, Human Reproduction
  • A major increase in oocyte cryopreservation cycles in the USA, Australia and New Zealand since 2010 is highlighted by younger women but a need for standardized data collection, 2020, Human Reproduction
  • Characterization of an artificial intelligence model for ranking static images of blastocyst stage embryos, 2022, Fertility and Sterility
  • Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology, 2022, Human Reproduction

Denny Sakkas has collaborated frequently with several researchers, indicating strong professional connections within their field. Frequent co-authors include:

  • Denis A. Vaughan
  • Alan S. Penzias
  • Thomas L. Toth
  • Jaimin S. Shah
  • Ann Korkidakis

The scientist has a notable presence in a variety of academic journals specializing in reproductive health and medicine. The primary publication venues are:

  • Fertility and Sterility
  • Human Reproduction
  • Reproductive BioMedicine Online
  • Journal of Assisted Reproduction and Genetics
  • Obstetrical & Gynecological Survey

The diversity of journals and collaboration with frequent co-authors underscores an active engagement with ongoing research and discourse in reproductive medicine and associated biomedical fields. This enables a blend of clinical, laboratory, and technological insights across multiple dimensions of reproductive biology and health.

Best Publications

  • Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis

    Denny Sakkas;Juan G. Alvarez;Juan G. Alvarez

  • ORIGIN OF DNA DAMAGE IN EJACULATED HUMAN SPERMATOZOA

    Denny Sakkas;Ewa Mariethoz;Giancarlo Manicardi;Davide Bizzaro

  • Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.

    Santiago Munné;Brian Kaplan;John L. Frattarelli;Tim Child

  • Early cleavage of in-vitro fertilized human embryos to the 2-cell stage: a novel indicator of embryo quality and viability.

    Youssef Shoukir;Aldo Campana;Tim Farley;Denny Sakkas

  • Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

    Ashok Agarwal;Neel Parekh;Manesh Kumar Panner Selvam;Ralf Henkel;Ralf Henkel

  • Early cleavage of human embryos to the two-cell stage after intracytoplasmic sperm injection as an indicator of embryo viability.

    Denny Sakkas;Youssef Shoukir;Didier Chardonnens;Patrizia Grace Bianchi

  • Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization

    Emre Seli;Denny Sakkas;Richard Scott;Shing C. Kwok

  • Protein phosphorylation in mammalian spermatozoa.

    Françoise Urner;Denny Sakkas

  • Blastocyst development from supernumerary embryos after intracytoplasmic sperm injection: a paternal influence?

    Youssef Shoukir;Didier Chardonnens;Aldo Campana;Denny Sakkas

  • Metabolomics and its application for non-invasive embryo assessment in IVF

    Lucy Botros;Denny Sakkas;Emre Seli

  • Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study.

    Richard Scott;Emre Seli;Kathy Miller;Denny Sakkas

  • Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization.

    Emre Seli;Lucy Botros;Denny Sakkas;David H. Burns

  • Cellular maturity and apoptosis in human sperm: creatine kinase, caspase-3 and Bcl-XL levels in mature and diminished maturity sperm.

    Sevil Cayli;Denny Sakkas;Lynne Vigue;Ramazan Demir

  • From oocyte to baby: a clinical evaluation of the biological efficiency of in vitro fertilization.

    Pasquale Patrizio;Denny Sakkas

  • Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer.

    Emre Seli;Carlijn G. Vergouw;Hiroshi Morita;Lucy Botros

  • Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: a prospective randomized trial

    T Hardarson;A Ahlström;L Rogberg;L Botros

  • Assessment of early cleaving in vitro fertilized human embryos at the 2-cell stage before transfer improves embryo selection

    Denny Sakkas;Gail Percival;Yvonne D’Arcy;Khaldoun Sharif

  • Relationship between the presence of endogenous nicks and sperm chromatin packaging in maturing and fertilizing mouse spermatozoa.

    Denny Sakkas;Giancarlo Manicardi;Patrizia Grace Bianchi;Davide Bizzaro

  • Protein Tyrosine Phosphorylation in Sperm During Gamete Interaction in the Mouse: The Influence of Glucose

    Françoise Urner;Greet Leppens-Luisier;Denny Sakkas

  • Assessment of embryo viability: the ability to select a single embryo for transfer--a review.

    D.K. Gardner;D. Sakkas

Frequent Co-Authors

David K. Gardner
David K. Gardner University of Melbourne
Carlos Simón
Carlos Simón University of Valencia
Aydin Arici
Aydin Arici Yale University
Alice D. Domar
Alice D. Domar Harvard Medical School
Hugh S. Taylor
Hugh S. Taylor Yale University
Thomas D'Hooghe
Thomas D'Hooghe Yale University
Marcos Meseguer
Marcos Meseguer University of Valencia
Kevin Eggan
Kevin Eggan Harvard University
Dagan Wells
Dagan Wells John Radcliffe Hospital
John L. Rinn
John L. Rinn University of Colorado Boulder

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