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D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
30395
World Ranking
3113
National Ranking
1575

Overview

Cynthia L. Sears is affiliated with Johns Hopkins University in the United States. Their research focuses extensively on medicine, with significant contributions in biochemistry, genetics, and molecular biology. The subfields of their work include molecular biology, oncology, epidemiology, infectious diseases, and surgery.

The scientist's main research topics cover gut microbiota and health, cancer immunotherapy and biomarkers, Clostridium difficile and Clostridium perfringens research, Mycobacterium research and diagnosis, colorectal cancer screening and detection, cancer research and treatments, as well as pancreatic and hepatic oncology research.

They have published multiple papers in well-known venues such as Gastroenterology, The Journal of Infectious Diseases, Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), and Cancer Discovery. Their frequent coauthors include Julia L. Drewes, Shaoguang Wu, James R. White, Fyza Y. Shaikh, and Martha J. Shrubsole.

Notable recent papers include:

  • Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps (2021, Cell)
  • A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes (2021, Cancer Discovery)
  • Intestinal Bacteria Maintain Adult Enteric Nervous System and Nitrergic Neurons via Toll-like Receptor 2-induced Neurogenesis in Mice (2020, Gastroenterology)
  • Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice (2022, Cancer Discovery)
  • Prevalence and association of pks+ Escherichia coli with colorectal cancer in patients at the University Malaya Medical Centre, Malaysia (2020, PLoS ONE)

Best Publications

  • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

    Shaoguang Wu;Ki Jong Rhee;Ki Jong Rhee;Ki Jong Rhee;Emilia Albesiano;Shervin Rabizadeh

  • The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints

    Nicolas J. Llosa;Michael Cruise;Ada Tam;Elizabeth C. Wicks

  • Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

    Erick Riquelme;Erick Riquelme;Yu Zhang;Liangliang Zhang;Maria Montiel

  • Microbes, Microbiota, and Colon Cancer

    Cynthia L. Sears;Wendy S. Garrett

  • Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

    Christine M. Dejea;Payam Fathi;John M. Craig;Annemarie Boleij;Annemarie Boleij

  • Microbiota organization is a distinct feature of proximal colorectal cancers

    Christine M. Dejea;Elizabeth C. Wick;Elizabeth M. Hechenbleikner;James R. White

  • Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.

    Cynthia L. Sears;James B. Kaper

  • The emerging clinical importance of non-O157 Shiga toxin-producing Escherichia coli.

    Kristine E. Johnson;Cheleste M. Thorpe;Cynthia L. Sears

  • The Bacteroides fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients

    Annemarie Boleij;Elizabeth M. Hechenbleikner;Andrew C. Goodwin;Ruchi Badani

  • Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

    Heather M. O'Hagan;Wei Wang;Subhojit Sen;Christina DeStefano Shields

  • Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.

    Liam Chung;Erik Thiele Orberg;Abby L. Geis;June L. Chan

  • Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.

    Andrew C. Goodwin;Christina E. Destefano Shields;Shaoguang Wu;David L. Huso

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • A dynamic partnership: celebrating our gut flora.

    Cynthia L. Sears

  • Enterotoxigenic Bacteroides fragilis: a Rogue among Symbiotes

    Cynthia L. Sears

  • Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin

    Shaoguang Wu;Kuei Cheng Lim;Julie Huang;Roxan F. Saidi

  • Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation

    Shaoguang Wu;Patrice J. Morin;Djik Maouyo;Cynthia L. Sears

  • Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia

    Florencia McAllister;Jennifer M. Bailey;Janivette Alsina;Christopher J. Nirschl

  • Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis

    Cynthia L. Sears;Abby L. Geis;Franck Housseau

  • Metabolism links bacterial biofilms and colon carcinogenesis

    Caroline H. Johnson;Christine M. Dejea;David Edler;Linh T. Hoang

Frequent Co-Authors

Franck Housseau
Franck Housseau Johns Hopkins University School of Medicine
Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine
David L. Huso
David L. Huso Johns Hopkins University
Robert A. Anders
Robert A. Anders Johns Hopkins University School of Medicine
Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Kenneth W. Kinzler
Kenneth W. Kinzler Johns Hopkins University
Luis A. Diaz
Luis A. Diaz Memorial Sloan Kettering Cancer Center
Francis M. Giardiello
Francis M. Giardiello Johns Hopkins University School of Medicine
Elizabeth M. Jaffee
Elizabeth M. Jaffee Johns Hopkins University
Nickolas Papadopoulos
Nickolas Papadopoulos Johns Hopkins University School of Medicine

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