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Constance E. Brinckerhoff

Constance E. Brinckerhoff

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
19314
World Ranking
5926
National Ranking
2804

Overview

Constance E. Brinckerhoff is affiliated with Dartmouth College in the United States. Their research spans multiple fields within biomedical sciences, focusing on areas such as oncology, immunology, rheumatology, radiology, nuclear medicine, and cancer research.

The scholar's recent publications include works published in prominent venues. Notable papers include:

  • Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses, 2021, Science Translational Medicine
  • Editorial Board, 2020, Journal of Biological Chemistry
  • Editorial Board, 2020, Journal of Biological Chemistry
  • Editorial Board, 2020, Journal of Biological Chemistry
  • Editorial Board, 2020, Journal of Biological Chemistry

Constance E. Brinckerhoff has contributed 13 publications to the Journal of Biological Chemistry, demonstrating a consistent engagement with this journal. Other publication venues include Science Translational Medicine and UNC Libraries.

Their research covers a range of scientific topics, including:

  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • Rheumatoid Arthritis Research and Therapies
  • HER2/EGFR in Cancer Research
  • Monoclonal and Polyclonal Antibodies Research
  • Protease and Inhibitor Mechanisms

Within subfields, their work focuses on:

  • Oncology
  • Immunology
  • Rheumatology
  • Radiology, Nuclear Medicine and Imaging
  • Cancer Research

Frequent collaborations are evident with several researchers, including Lila M. Gierasch, F. Peter Guengerich, Ruma Banerjee, Roger Colbran, and Peter Cresswell. Each of these coauthors has worked with Brinckerhoff on approximately 13 occasions, indicating ongoing and sustained partnerships.

Best Publications

  • Matrix metalloproteinases: a tail of a frog that became a prince

    Constance E. Brinckerhoff;Lynn M. Matrisian

  • Matrix metalloproteinases: role in arthritis.

    Peter S Burrage;Kimberlee S Mix;Constance E Brinckerhoff

  • Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

    Matthew P Vincenti;Constance E Brinckerhoff

  • Interleukin‐1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c‐jun N‐terminal kinase, and nuclear factor κB: Differential regulation of collagenase 1 and collagenase 3

    John A. Mengshol;Matthew P. Vincenti;Charles I. Coon;Aaron Barchowsky

  • A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-1 Promoter Creates an Ets Binding Site and Augments Transcription

    Joni L. Rutter;Teresa I. Mitchell;Giovanna Butticè;Jennifer Meyers

  • The AP-1 site and MMP gene regulation: what is all the fuss about?

    Ulrike Benbow;Constance E. Brinckerhoff

  • Interstitial collagenases as markers of tumor progression.

    Constance E. Brinckerhoff;Joni L. Rutter;Ulrike Benbow

  • Regulating Expression of the Gene for Matrix Metalloproteinase-1 (Collagenase): Mechanisms that Control Enzyme Activity, Transcription, and mRNA Stability

    Matthew P. Vincenti;Lori A. White;Daniel J. Schroen;Ulrike Benbow

  • IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.

    John A. Mengshol;Matthew P. Vincenti;Constance E. Brinckerhoff

  • Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts.

    Matthew P. Vincenti;Charles I. Coon;Constance E. Brinckerhoff

  • Using inhibitors of metalloproteinases to treat arthritis. Easier said than done

    Matthew P. Vincenti;Ian M. Clark;Constance E. Brinckerhoff;Constance E. Brinckerhoff

  • Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells.

    C O Quinn;D K Scott;C E Brinckerhoff;L M Matrisian

  • Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.

    Brenda L Petrella;Jouko Lohi;Constance E Brinckerhoff

  • Matrix metalloproteinases as therapeutic targets in arthritic diseases: Bull's‐eye or missing the mark?

    John A. Mengshol;Kimberlee S. Mix;Constance E. Brinckerhoff

  • Autocrine induction of collagenase by serum amyloid A-like and beta 2-microglobulin-like proteins

    Constance E. Brinckerhoff;Teresa I. Mitchell;Michael J. Karmilowicz;Barbara Kluve-Beckerman

  • Inhibition by Retinoic Acid of Collagenase Production in Rheumatoid Synovial Cells

    Constance E. Brinckerhoff;Rodger M. McMillan;Jean-Michel Dayer;Edward D. Harris

  • Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta

    Matthew P Vincenti;Constance E Brinckerhoff

  • p53 down-regulates human matrix metalloproteinase-1 (Collagenase-1) gene expression.

    Yubo Sun;Yi Sun;Leonor Wenger;Joni L. Rutter

  • Overexpression of Collagenase 1 (MMP-1) Is Mediated by the ERK Pathway in Invasive Melanoma Cells ROLE OF BRAF MUTATION AND FIBROBLAST GROWTH FACTOR SIGNALING

    Jonathan T. Huntington;Janiel M. Shields;Channing J. Der;Colby A. Wyatt

  • Manganese Superoxide Dismutase Signals Matrix Metalloproteinase Expression via H2O2-dependent ERK1/2 Activation

    Aparna C. Ranganathan;Kristin K. Nelson;Ana M. Rodriguez;Kwi Hye Kim

Frequent Co-Authors

Michael B. Sporn
Michael B. Sporn Dartmouth College
Hideaki Nagase
Hideaki Nagase University of Oxford
Herman S. Cheung
Herman S. Cheung University of Miami
Marc S. Ernstoff
Marc S. Ernstoff Roswell Park Cancer Institute
Aaron Barchowsky
Aaron Barchowsky University of Pittsburgh
Evan D. Rosen
Evan D. Rosen Beth Israel Deaconess Medical Center
Lynn M. Matrisian
Lynn M. Matrisian Vanderbilt University
Gillian Murphy
Gillian Murphy University of Cambridge
Laurie J. Ozelius
Laurie J. Ozelius Harvard University
James F. Gusella
James F. Gusella Harvard University

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