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Biology and Biochemistry

D-Index
60
Citations
11812
World Ranking
12048
National Ranking
929

Overview

Colin Farquharson is affiliated with the University of Edinburgh in the United Kingdom. Their research spans medicine and biochemistry, genetics, and molecular biology, with significant contributions to molecular biology, endocrinology, diabetes and metabolism, rheumatology, nephrology, and physiology.

The scientist's work has focused on several topics including:

  • Alkaline Phosphatase Research Studies
  • Heterotopic Ossification and Related Conditions
  • Parathyroid Disorders and Treatments
  • Bone Metabolism and Diseases
  • Bone and Joint Diseases
  • Bone and Dental Protein Studies
  • Metabolomics and Mass Spectrometry Studies

Farquharson's recent publications showcase research in cellular biochemistry, skeletal regulation, gene therapy, and dental biology. Prominent examples include:

  • "The role of miR-29 family in disease", 2021, Journal of Cellular Biochemistry
  • "PHOSPHO1 is a skeletal regulator of insulin resistance and obesity", 2020, BMC Biology
  • "Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP-D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia", 2022, JBMR Plus
  • "Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice", 2020, Journal of Cellular Physiology
  • "Transcriptomic profiling of feline teeth highlights the role of matrix metalloproteinase 9 (MMP9) in tooth resorption", 2020, Scientific Reports

The scientist frequently publishes in journals such as Cell Biochemistry and Function, bioRxiv (Cold Spring Harbor Laboratory), Journal of Endocrinology, Bone Reports, and the Journal of Bone and Mineral Research. The number of publications in these venues ranges from several articles to over a dozen for some.

Collaboration is a significant aspect of Farquharson's research. Frequent coauthors include Louise A. Stephen, Katherine Staines, Scott Dillon, A Pitsillides, and Martin Hewison, reflecting interdisciplinary and collaborative efforts in their scientific endeavors.

Best Publications

  • Spironolactone Increases Nitric Oxide Bioactivity, Improves Endothelial Vasodilator Dysfunction, and Suppresses Vascular Angiotensin I/Angiotensin II Conversion in Patients With Chronic Heart Failure

    Colin A. J. Farquharson;Allan D. Struthers

  • Allopurinol improves endothelial dysfunction in chronic heart failure

    Colin A.J. Farquharson;Robert Butler;Alexander Hill;Jill J.F. Belch

  • Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting.

    Samantha L. Eaton;Sarah L. Roche;Maica Llavero Hurtado;Karla J. Oldknow

  • The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.

    Dongxing Zhu;Neil Charles Wallace Mackenzie;José Luis Millán;Colin Farquharson

  • Aldosterone induces acute endothelial dysfunction in vivo in humans: evidence for an aldosterone-induced vasculopathy.

    Colin A J Farquharson;Allan D Struthers

  • Loss of Skeletal Mineralization by the Simultaneous Ablation of PHOSPHO1 and Alkaline Phosphatase Function: A Unified Model of the Mechanisms of Initiation of Skeletal Calcification

    Manisha C Yadav;Ana Maria Sper Simão;Sonoko Narisawa;Carmen Huesa

  • The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling

    Katherine A Staines;Vicky E MacRae;Colin Farquharson

  • Skeletal development in the meat-type chicken

    B Williams;S Solomon;D Waddington;B Thorp

  • Chondrocytes and longitudinal bone growth: the development of tibial dyschondroplasia.

    C. Farquharson;D. Jefferies

  • Functional Involvement of PHOSPHO1 in Matrix Vesicle–Mediated Skeletal Mineralization†

    Scott Roberts;Sonoko Narisawa;Dympna Harmey;José Luis Millán

  • Bone Strength During Growth: Influence of Growth Rate on Cortical Porosity and Mineralization

    B Williams;D Waddington;D H Murray;Colin Farquharson

  • Characterisation of matrix vesicles in skeletal and soft tissue mineralisation

    L. Cui;D.A. Houston;C. Farquharson;V.E. MacRae

  • Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles.

    Pietro Ciancaglini;Manisha C Yadav;Ana Maria Sper Simão;Sonoko Narisawa

  • Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities

    Scott J. Roberts;Alan J. Stewart;Peter J. Sadler;Colin Farquharson

  • Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice

    Neil Charles Wallace Mackenzie;Dongxing Zhu;Elspeth M. Milne;Rob van 't Hof

  • Mechanisms and Clinical Consequences of Vascular Calcification

    Dongxing Zhu;Neil Charles Wallace Mackenzie;Colin Farquharson;Vicky E Macrae

  • Growth and the Growth Hormone-Insulin Like Growth Factor 1 Axis in Children With Chronic Inflammation: Current Evidence, Gaps in Knowledge, and Future Directions

    S C Wong;Ross Dobie;M A Altowati;G A Werther

  • The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins

    S. F. Ahmed;Colin Farquharson

  • The role of sex steroids in controlling pubertal growth.

    R. J. Perry;Colin Farquharson;S. F. Ahmed

  • The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling ([Correction:] vol 214, pg 241, 2012)

    Katherine Staines;Vicky E. MacRae;Colin Farquharson

Frequent Co-Authors

Andrew A. Pitsillides
Andrew A. Pitsillides Royal Veterinary College
José Luis Millán
José Luis Millán Discovery Institute
David J. Buttle
David J. Buttle University of Sheffield
Allan D. Struthers
Allan D. Struthers University of Dundee
Gerard Karsenty
Gerard Karsenty Columbia University
Alan Boyde
Alan Boyde Queen Mary University of London
Mark Hopkinson
Mark Hopkinson University of Sheffield
Stuart H. Ralston
Stuart H. Ralston University of Edinburgh
David W. Burt
David W. Burt University of Queensland

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