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José Luis Millán

José Luis Millán

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
23002
World Ranking
3907
National Ranking
1933

Overview

José Luis Millán is affiliated with the Discovery Institute in the United States. Their research is primarily situated at the intersection of medicine and biochemistry, genetics, and molecular biology, with a particular focus on endocrinology, diabetes, and metabolism. Their scholarly output also touches on rheumatology, nephrology, and orthopedics and sports medicine.

The core topics of Millán's research include alkaline phosphatase research studies, parathyroid disorders and treatments, heterotopic ossification and related conditions, bone and joint diseases, biochemical and molecular research, bone and dental protein studies, and investigations into S100 proteins and annexins.

Frequent collaborators in Millán's work include Massimo Bottini, Pietro Ciancaglini, Ana Paula Ramos, Sonoko Narisawa, and Maytê Bolean, each contributing to numerous publications and reflecting sustained collaborative relationships.

Millán's research has appeared in a range of specialized journals, with repeated contributions to the Journal of Bone and Mineral Research (8 publications), JBMR Plus (6 publications), Bone (5 publications), Bone Reports (4 publications), and the International Journal of Molecular Sciences (3 publications).

Highlighted recent papers authored or co-authored by José Luis Millán include:

  • Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine, 2021, Nature
  • Localization of Annexin A6 in Matrix Vesicles During Physiological Mineralization, 2020, International Journal of Molecular Sciences
  • Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells, 2020, Biochimica et Biophysica Acta (BBA) - General Subjects
  • Phosphatidylserine controls calcium phosphate nucleation and growth on lipid monolayers: A physicochemical understanding of matrix vesicle-driven biomineralization, 2020, Journal of Structural Biology
  • Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl−/− Mice, 2020, Journal of Bone and Mineral Research

Best Publications

  • Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

    Lovisa Hessle;Kristen A. Johnson;H. Clarke Anderson;Sonoko Narisawa

  • Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone

    Monzur Murshed;Dympna Harmey;José Luis Millán;Marc D. McKee

  • Enzyme-replacement therapy in life-threatening hypophosphatasia.

    Michael P. Whyte;Cheryl R. Greenberg;Nada J. Salman;Michael B. Bober

  • Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.

    Dympna Harmey;Lovisa Hessle;Sonoko Narisawa;Kristen A. Johnson

  • Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia

    Sonoko Narisawa;Nils Fröhlander;Nils Fröhlander;José Luis Millán;José Luis Millán

  • Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

    Lingyin Li;Qian Yin;Pia Kuss;Zoltan Maliga

  • Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia

    Kenton N. Fedde;Libby Blair;Julie Silverstein;Stephen P. Coburn

  • Impaired Calcification Around Matrix Vesicles of Growth Plate and Bone in Alkaline Phosphatase-Deficient Mice

    H. Clarke Anderson;Joseph B. Sipe;Lovisa Hessle;Rama Dhamyamraju

  • Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: Potential mechanism for uremic vascular calcification

    K.A. Lomashvili;P. Garg;S. Narisawa;J.L. Millan

  • Alkaline Phosphatase and Hypophosphatasia

    José Luis Millán;Michael P. Whyte;Michael P. Whyte

  • The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.

    Dongxing Zhu;Neil Charles Wallace Mackenzie;José Luis Millán;Colin Farquharson

  • Immortalization of germ cells and somatic testicular cells using the SV40 large T antigen.

    Marie Claude Hofmann;Sonoko Narisawa;Rex A. Hess;Jose Luis Millán

  • Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice.

    Charlotte Wennberg;Lovisa Hessle;Pernilla Lundberg;Sonia Mauro

  • Loss of Skeletal Mineralization by the Simultaneous Ablation of PHOSPHO1 and Alkaline Phosphatase Function: A Unified Model of the Mechanisms of Initiation of Skeletal Calcification

    Manisha C Yadav;Ana Maria Sper Simão;Sonoko Narisawa;Carmen Huesa

  • Enzyme Replacement Therapy for Murine Hypophosphatasia

    José Luis Millán;Sonoko Narisawa;Isabelle Lemire;Thomas P Loisel

  • Novel Inhibitors of Alkaline Phosphatase Suppress Vascular Smooth Muscle Cell Calcification

    Sonoko Narisawa;Dympna Harmey;Manisha C Yadav;W Charles O'Neill

  • Intestinal alkaline phosphatase prevents metabolic syndrome in mice

    Kanakaraju Kaliannan;Sulaiman R. Hamarneh;Konstantinos P. Economopoulos;Sayeda Nasrin Alam

  • Placental Alkaline Phosphatase as a Tumor Marker for Seminoma

    P.H. Lange;P.H. Lange;P.H. Lange;J.L. Millan;J.L. Millan;J.L. Millan;T. Stigbrand;T. Stigbrand;T. Stigbrand;R.L. Vessella;R.L. Vessella;R.L. Vessella

  • Accelerated fat absorption in intestinal alkaline phosphatase knockout mice.

    Sonoko Narisawa;Lei Huang;Arata Iwasaki;Hideaki Hasegawa

  • Immortalized germ cells undergo meiosis in vitro.

    Marie Claude Hofmann;Rex A. Hess;Erwin Goldberg;José Luis Millán

Frequent Co-Authors

Colin Farquharson
Colin Farquharson University of Edinburgh
Martha J. Somerman
Martha J. Somerman National Institutes of Health
Michael P. Whyte
Michael P. Whyte Washington University in St. Louis
Marc D. McKee
Marc D. McKee McGill University
Panagiotis A. Tsonis
Panagiotis A. Tsonis University of Dayton
Robert Terkeltaub
Robert Terkeltaub University of California, San Diego
Gerard Karsenty
Gerard Karsenty Columbia University
Andrew A. Pitsillides
Andrew A. Pitsillides Royal Veterinary College
Robert L. Sah
Robert L. Sah University of California, San Diego

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