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Neuroscience

D-Index
31
Citations
4021
World Ranking
9579
National Ranking
711

Overview

Charles H. Large is affiliated with Autifony Therapeutics in the United Kingdom, focusing on research within medicine, biochemistry, genetics, molecular biology, and neuroscience. Their expertise spans multiple subfields including molecular biology, cellular and molecular neuroscience, cardiology and cardiovascular medicine, physiology, and neurology.

The scientist's research primarily centers on ion channel regulation and function, a topic extensively explored in their work. Additional significant areas of study include neuroscience and neuropharmacology research, cardiac electrophysiology and arrhythmias, Alzheimer's disease research and treatments, neurological disorders and treatments, urinary bladder and prostate research, and the neuroscience of respiration and sleep.

Their publication record includes contributions to a variety of scientific venues. The most frequent publication outlets are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Medicinal Chemistry Letters
  • Brain and Neuroscience Advances
  • Journal of Psychopharmacology
  • Cell Reports Medicine

Recent published papers exemplify a focus on ion channels and neurological conditions. Selected works include:

  • "Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia" (2020), ACS Medicinal Chemistry Letters
  • "Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease" (2022), Brain and Neuroscience Advances
  • "The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [18F]-FDOPA imaging in schizophrenia" (2022), Journal of Psychopharmacology
  • "Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy" (2024), Cell Reports Medicine
  • "The binding and mechanism of a positive allosteric modulator of Kv3 channels" (2024), Nature Communications

Collaboration is a notable aspect of their career, having worked frequently with several coauthors including Giuseppe Alvaro, Martin J. Gunthorpe, Nadia Pilati, Stephen J. Kaar, and Alice Sharman.

Best Publications

  • State of the art: Pharmacologic effects on cortical excitability measures tested by transcranial magnetic stimulation.

    Walter Paulus;Joseph Classen;Leonardo G. Cohen;Charles H. Large

  • The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

    Martin J. Gunthorpe;Charles H. Large;Raman Sankar

  • Lamotrigine as add-on therapy in schizophrenia: results of 2 placebo-controlled trials.

    Donald C Goff;Richard Keefe;Leslie Citrome;Katherine Davy

  • Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

    R. Anderson;J.C. Barnes;T.V.P. Bliss;D.P. Cain

  • Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs

    Charles H. Large

  • Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat.

    Nagi F. Idris;P. Repeto;Joanna C. Neill;C.H. Large

  • Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania

    Roberto Arban;Gabriella Maraia;Kim Brackenborough;Lisa Winyard

  • Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine.

    Alessandro Gozzi;Charles H Large;Adam Schwarz;Simone Bertani

  • Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model

    Sharon C Stratton;Charles H Large;Brian Cox;Gary Davies

  • Interleaved transcranial magnetic stimulation/functional MRI confirms that lamotrigine inhibits cortical excitability in healthy young men.

    Xingbao Li;Charlotte C Tenebäck;Ziad Nahas;F Andrew Kozel

  • Acoustic over-exposure triggers burst firing in dorsal cochlear nucleus fusiform cells

    Nadia Pilati;Charles Large;Ian D. Forsythe;Martine Hamann

  • The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use

    Charles H. Large;David M. Sokal;Astrid Nehlig;Martin J. Gunthorpe

  • The potential role of lamotrigine in schizophrenia.

    Charles H. Large;Elizabeth L. Webster;Donald C. Goff

  • Chronic stress‐induced alterations in amygdala responsiveness and behavior – modulation by trait anxiety and corticotropin‐releasing factor systems

    Carmen Sandi;M. Isabel Cordero;Annarosa Ugolini;Emilio Varea

  • Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice.

    Suzanne A. Brody;Mark A. Geyer;Charles H. Large

  • The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat.

    Charles H. Large;Mikhail Kalinichev;Adam Lucas;Corrado Carignani

  • An investigation of the efficacy of mood stabilizers in rodent models of prepulse inhibition.

    Jacob C. Ong;Suzanne A. Brody;Charles H. Large;Mark A. Geyer

  • Modulators of Kv3 potassium channels rescue the auditory function of Fragile X mice

    Lynda El-Hassar;Lei Song;Winston J.T. Tan;Charles H. Large

  • A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons

    Marcelo D. Rosato-Siri;Erika Zambello;Chiara Mutinelli;Nicoletta Garbati

  • Mechanisms contributing to central excitability changes during hearing loss

    Nadia Pilati;Matias J. Ison;Matthew Barker;Mike Mulheran

  • Using interleaved transcranial magnetic stimulation/functional magnetic resonance imaging (fMRI) and dynamic causal modeling to understand the discrete circuit specific changes of medications: Lamotrigine and valproic acid changes in motor or prefrontal effective connectivity

    Xingbao Li;Charles H. Large;Raffaella Ricci;Joseph J. Taylor

  • Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability

    Xingbao Li;Raffaella Ricci;Charles H. Large;Berry Anderson

  • Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons

    Maile Reed Brown;Lynda El-Hassar;Yalan Zhang;Giuseppe Alvaro

Frequent Co-Authors

Mark S. George
Mark S. George Medical University of South Carolina
Xingbao Li
Xingbao Li Medical University of South Carolina
Fiona E. N. LeBeau
Fiona E. N. LeBeau Newcastle University
Mark O. Cunningham
Mark O. Cunningham Trinity College Dublin
Daryl E. Bohning
Daryl E. Bohning Medical University of South Carolina
Shane McKie
Shane McKie University of Manchester
Mark A. Geyer
Mark A. Geyer University of California, San Diego
Daniel B. Polley
Daniel B. Polley Massachusetts Eye and Ear Infirmary
Alessandro Gozzi
Alessandro Gozzi Italian Institute of Technology
Ian D. Forsythe
Ian D. Forsythe University of Leicester

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