World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
31
Citations
4021
World Ranking
9579
National Ranking
710

Charles H. Large publication distribution in Neuroscience in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Neuroscience in 2026. The highlighted bar marks where Charles H. Large sits on this spectrum.

38–47 publications: 18 scientists 48–57 publications: 79 scientists 58–67 publications: 193 scientists 68–77 publications: 323 scientists 78–87 publications: 406 scientists 88–97 publications: 452 scientists 98–107 publications: 539 scientists 108–117 publications: 505 scientists 118–127 publications: 522 scientists 128–137 publications: 469 scientists 138–147 publications: 456 scientists 148–157 publications: 459 scientists 158–167 publications: 397 scientists 168–177 publications: 383 scientists 178–187 publications: 350 scientists 188–197 publications: 302 scientists 198–207 publications: 306 scientists 208–217 publications: 262 scientists 218–227 publications: 242 scientists 228–237 publications: 220 scientists 238–247 publications: 203 scientists 248–257 publications: 174 scientists 258–267 publications: 176 scientists 268–277 publications: 175 scientists 278–287 publications: 125 scientists 288–297 publications: 116 scientists 298–307 publications: 127 scientists 308–317 publications: 128 scientists 318–327 publications: 99 scientists 328–337 publications: 89 scientists 338–347 publications: 78 scientists 348–357 publications: 96 scientists 358–367 publications: 66 scientists 368–377 publications: 59 scientists 378–387 publications: 65 scientists 388–397 publications: 54 scientists 398–407 publications: 48 scientists 408–417 publications: 49 scientists 418–427 publications: 34 scientists 428–437 publications: 31 scientists 438–447 publications: 30 scientists 448–457 publications: 31 scientists 458–467 publications: 36 scientists 468–477 publications: 40 scientists 478–487 publications: 35 scientists 488–497 publications: 30 scientists 498–507 publications: 23 scientists 508–517 publications: 26 scientists 518–527 publications: 20 scientists 528–537 publications: 23 scientists 538–547 publications: 20 scientists 548–557 publications: 20 scientists 558–567 publications: 17 scientists 568–577 publications: 14 scientists 578–587 publications: 20 scientists 588–597 publications: 20 scientists 598–607 publications: 19 scientists 608–617 publications: 18 scientists 618–627 publications: 17 scientists 628–637 publications: 11 scientists 638–647 publications: 11 scientists 648–657 publications: 11 scientists 658–667 publications: 8 scientists 668–677 publications: 7 scientists 678–687 publications: 11 scientists 688–697 publications: 10 scientists 698–707 publications: 4 scientists 708–717 publications: 6 scientists 718–727 publications: 5 scientists 728–737 publications: 5 scientists 738–747 publications: 9 scientists 748–757 publications: 9 scientists 758–767 publications: 3 scientists 768–777 publications: 7 scientists 778–787 publications: 7 scientists 788–797 publications: 6 scientists 798–807 publications: 2 scientists 808–817 publications: 2 scientists 818–827 publications: 7 scientists 828–837 publications: 0 scientists 838–847 publications: 9 scientists 848–857 publications: 3 scientists 858–867 publications: 1 scientists 868–877 publications: 3 scientists 878–886 publications: 6 scientists 887+ publications: 100 scientists
38 publications 887+

This scientist: 88 publications — 11th percentile

11% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 887 publications or more.

Charles H. Large D-index placement in Neuroscience in 2026

The chart shows the D-index (discipline H-index) distribution of Neuroscience scientists ranked by Research.com in 2026. The highlighted bar marks where Charles H. Large sits on this spectrum.

30–31 D-Index: 42 scientists 32–33 D-Index: 172 scientists 34–35 D-Index: 296 scientists 36–37 D-Index: 435 scientists 38–39 D-Index: 459 scientists 40–41 D-Index: 456 scientists 42–43 D-Index: 467 scientists 44–45 D-Index: 478 scientists 46–47 D-Index: 512 scientists 48–49 D-Index: 435 scientists 50–51 D-Index: 425 scientists 52–53 D-Index: 418 scientists 54–55 D-Index: 392 scientists 56–57 D-Index: 357 scientists 58–59 D-Index: 334 scientists 60–61 D-Index: 328 scientists 62–63 D-Index: 260 scientists 64–65 D-Index: 278 scientists 66–67 D-Index: 239 scientists 68–69 D-Index: 250 scientists 70–71 D-Index: 210 scientists 72–73 D-Index: 200 scientists 74–75 D-Index: 189 scientists 76–77 D-Index: 170 scientists 78–79 D-Index: 146 scientists 80–81 D-Index: 113 scientists 82–83 D-Index: 126 scientists 84–85 D-Index: 100 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 99 scientists 90–91 D-Index: 84 scientists 92–93 D-Index: 85 scientists 94–95 D-Index: 72 scientists 96–97 D-Index: 76 scientists 98–99 D-Index: 45 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 43 scientists 104–105 D-Index: 32 scientists 106–107 D-Index: 45 scientists 108–109 D-Index: 50 scientists 110–111 D-Index: 32 scientists 112–113 D-Index: 39 scientists 114–115 D-Index: 32 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 27 scientists 120–121 D-Index: 19 scientists 122–123 D-Index: 23 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 16 scientists 128–129 D-Index: 24 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 21 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 14 scientists 138–139 D-Index: 15 scientists 140–141 D-Index: 10 scientists 142–143 D-Index: 10 scientists 144–145 D-Index: 13 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 8 scientists 150–151 D-Index: 6 scientists 152–153 D-Index: 6 scientists 154–155 D-Index: 7 scientists 156–157 D-Index: 7 scientists 158–159 D-Index: 10 scientists 160–161 D-Index: 4 scientists 162 D-Index: 8 scientists 163+ D-Index: 100 scientists
30 D-Index 163+

This scientist: 31 D-Index — 1st percentile

1% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 163 D-Index or more.

Overview

Charles H. Large is affiliated with Autifony Therapeutics in the United Kingdom, focusing on research within medicine, biochemistry, genetics, molecular biology, and neuroscience. Their expertise spans multiple subfields including molecular biology, cellular and molecular neuroscience, cardiology and cardiovascular medicine, physiology, and neurology.

The scientist's research primarily centers on ion channel regulation and function, a topic extensively explored in their work. Additional significant areas of study include neuroscience and neuropharmacology research, cardiac electrophysiology and arrhythmias, Alzheimer's disease research and treatments, neurological disorders and treatments, urinary bladder and prostate research, and the neuroscience of respiration and sleep.

Their publication record includes contributions to a variety of scientific venues. The most frequent publication outlets are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Medicinal Chemistry Letters
  • Brain and Neuroscience Advances
  • Journal of Psychopharmacology
  • Cell Reports Medicine

Recent published papers exemplify a focus on ion channels and neurological conditions. Selected works include:

  • "Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia" (2020), ACS Medicinal Chemistry Letters
  • "Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease" (2022), Brain and Neuroscience Advances
  • "The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [18F]-FDOPA imaging in schizophrenia" (2022), Journal of Psychopharmacology
  • "Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy" (2024), Cell Reports Medicine
  • "The binding and mechanism of a positive allosteric modulator of Kv3 channels" (2024), Nature Communications

Collaboration is a notable aspect of their career, having worked frequently with several coauthors including Giuseppe Alvaro, Martin J. Gunthorpe, Nadia Pilati, Stephen J. Kaar, and Alice Sharman.

Best Publications

  • State of the art: Pharmacologic effects on cortical excitability measures tested by transcranial magnetic stimulation.

    Walter Paulus;Joseph Classen;Leonardo G. Cohen;Charles H. Large

  • The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

    Martin J. Gunthorpe;Charles H. Large;Raman Sankar

  • Lamotrigine as add-on therapy in schizophrenia: results of 2 placebo-controlled trials.

    Donald C Goff;Richard Keefe;Leslie Citrome;Katherine Davy

  • Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

    R. Anderson;J.C. Barnes;T.V.P. Bliss;D.P. Cain

  • Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs

    Charles H. Large

  • Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat.

    Nagi F. Idris;P. Repeto;Joanna C. Neill;C.H. Large

  • Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania

    Roberto Arban;Gabriella Maraia;Kim Brackenborough;Lisa Winyard

  • Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine.

    Alessandro Gozzi;Charles H Large;Adam Schwarz;Simone Bertani

  • Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model

    Sharon C Stratton;Charles H Large;Brian Cox;Gary Davies

  • Interleaved transcranial magnetic stimulation/functional MRI confirms that lamotrigine inhibits cortical excitability in healthy young men.

    Xingbao Li;Charlotte C Tenebäck;Ziad Nahas;F Andrew Kozel

  • Acoustic over-exposure triggers burst firing in dorsal cochlear nucleus fusiform cells

    Nadia Pilati;Charles Large;Ian D. Forsythe;Martine Hamann

  • The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use

    Charles H. Large;David M. Sokal;Astrid Nehlig;Martin J. Gunthorpe

  • The potential role of lamotrigine in schizophrenia.

    Charles H. Large;Elizabeth L. Webster;Donald C. Goff

  • Chronic stress‐induced alterations in amygdala responsiveness and behavior – modulation by trait anxiety and corticotropin‐releasing factor systems

    Carmen Sandi;M. Isabel Cordero;Annarosa Ugolini;Emilio Varea

  • Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice.

    Suzanne A. Brody;Mark A. Geyer;Charles H. Large

  • The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat.

    Charles H. Large;Mikhail Kalinichev;Adam Lucas;Corrado Carignani

  • An investigation of the efficacy of mood stabilizers in rodent models of prepulse inhibition.

    Jacob C. Ong;Suzanne A. Brody;Charles H. Large;Mark A. Geyer

  • Modulators of Kv3 potassium channels rescue the auditory function of Fragile X mice

    Lynda El-Hassar;Lei Song;Winston J.T. Tan;Charles H. Large

  • A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons

    Marcelo D. Rosato-Siri;Erika Zambello;Chiara Mutinelli;Nicoletta Garbati

  • Mechanisms contributing to central excitability changes during hearing loss

    Nadia Pilati;Matias J. Ison;Matthew Barker;Mike Mulheran

  • Using interleaved transcranial magnetic stimulation/functional magnetic resonance imaging (fMRI) and dynamic causal modeling to understand the discrete circuit specific changes of medications: Lamotrigine and valproic acid changes in motor or prefrontal effective connectivity

    Xingbao Li;Charles H. Large;Raffaella Ricci;Joseph J. Taylor

  • Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability

    Xingbao Li;Raffaella Ricci;Charles H. Large;Berry Anderson

  • Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons

    Maile Reed Brown;Lynda El-Hassar;Yalan Zhang;Giuseppe Alvaro

Frequent Co-Authors

Mark S. George
Mark S. George Medical University of South Carolina
Xingbao Li
Xingbao Li Medical University of South Carolina
Ziad Nahas
Ziad Nahas University of Minnesota
Leonard K. Kaczmarek
Leonard K. Kaczmarek Yale University
Fiona E. N. LeBeau
Fiona E. N. LeBeau Newcastle University
Mark O. Cunningham
Mark O. Cunningham Trinity College Dublin
Daryl E. Bohning
Daryl E. Bohning Medical University of South Carolina
Daniel B. Polley
Daniel B. Polley Massachusetts Eye and Ear Infirmary
Alessandro Gozzi
Alessandro Gozzi Italian Institute of Technology
Shane McKie
Shane McKie University of Manchester

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