World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
88
Citations
30547
World Ranking
1160
National Ranking
102

Medicine

D-Index
90
Citations
31702
World Ranking
12158
National Ranking
1147

Overview

Caroline O. S. Savage is affiliated with GlaxoSmithKline in the United Kingdom. Their research spans multiple disciplines within biomedical science, primarily focusing on biochemistry, genetics, molecular biology, immunology, microbiology, and medicine. The scientist's subfields of study include immunology, molecular biology, cancer research, pulmonary and respiratory medicine, and genetics.

Key topics addressed in Savage's work encompass microRNA in disease regulation, renal and related cancers, extracellular vesicles in disease, T-cell and B-cell immunology, immune cell function and interaction, psoriasis treatment and pathogenesis, and vasculitis and related conditions.

Their recent publications demonstrate a focus on immunological and molecular mechanisms relevant to disease states and therapeutic interventions:

  • Identifying cell-enriched miRNAs in kidney injury and repair (2020, JCI Insight)
  • Depletion of LAG-3+ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781 (2020, Clinical Pharmacology & Therapeutics)
  • A randomised study of rituximab and belimumab sequential therapy in PR3 ANCAassociated vasculitis (COMBIVAS): design of the study protocol (2022, Research Square)

Frequent collaborators in Savage's research include Robert B. Henderson, Katie Connor, Oliver Teenan, Carolynn Cairns, and Victoria Banwell. Their work has been published primarily in the venues JCI Insight, Clinical Pharmacology & Therapeutics, and Research Square.

Best Publications

  • Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis

    Rachel B. Jones;Jan Willem Cohen Tervaert;Thomas Hauser;Raashid Luqmani

  • Defining Early Morbidity of Radical Cystectomy for Patients with Bladder Cancer Using a Standardized Reporting Methodology

    Ahmad Shabsigh;Ruslan Korets;Kinjal C. Vora;Christine M. Brooks

  • Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis.

    R A Luqmani;P A Bacon;R J Moots;B A Janssen

  • Genetically Distinct Subsets within ANCA-Associated Vasculitis

    Paul A Lyons;Tim F Rayner;Sapna Trivedi;Julia U Holle

  • Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial.

    Kirsten de Groot;Lorraine Harper;David R.W. Jayne;Luis Felipe Flores Suarez

  • ANCA-associated vasculitis.

    A. Richard Kitching;Hans Joachim Anders;Neil Basu;Elisabeth Brouwer

  • International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies (ANCA)

    Judy Savige;David Gillis;Elizabeth Benson;David Davies

  • Microscopic polyarteritis: presentation, pathology and prognosis.

    Caroline O. S. Savage;C. G. Winearls;D. J. Evans;A. J. Rees

  • Development and initial validation of the vasculitis damage index for the standardized clinical assessment of damage in the systemic vasculitides

    A. R. Exley;P. A. Bacon;R. A. Luqmani;G. D. Kitas

  • Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial.

    Thomas F. Hiemstra;Michael Walsh;Alfred Mahr;Caroline O. Savage

  • Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up

    Lorraine Harper;Matthew D Morgan;Michael Walsh;Peter Hoglund

  • Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis

    Little Ma;Nightingale P;Verburgh Ca;Hauser T

  • Empirical Study of Data Sharing by Authors Publishing in PLoS Journals

    Caroline J. Savage;Andrew J. Vickers

  • Prospective Study of Tnf Blockade with Infliximab in Anti-Neutrophil Cytoplasmic Antibody-Associated Systemic Vasculitis

    Anthony Booth;Lorraine Harper;Tariq Hammad;Paul Bacon

  • A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis

    Rachel B. Jones;Alastair J. Ferraro;Afzal N. Chaudhry;Paul Brogan

  • The value of pulse cyclophosphamide in ANCA‐associated vasculitis: meta‐analysis and critical review

    Kirsten de Groot;Dwomoa Adu;Caroline O. S. Savage

  • Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells.

    C. O. S. Savage;B. E. Pottinger;G. Gaskin;C. D. Pusey

  • The surgical learning curve for laparoscopic radical prostatectomy: a retrospective cohort study.

    Andrew J Vickers;Caroline J Savage;Marcel Hruza;Ingolf Tuerk

  • Potential Impact of Postoperative Early Complications on the Timing of Adjuvant Chemotherapy in Patients Undergoing Radical Cystectomy: A High-Volume Tertiary Cancer Center Experience

    S. Machele Donat;Ahmad Shabsigh;Caroline Savage;Angel M. Cronin

  • Systematic Review of Pretreatment Prostate-Specific Antigen Velocity and Doubling Time As Predictors for Prostate Cancer

    Andrew J. Vickers;Caroline Savage;M. Frank O'Brien;Hans Lilja

  • Mycophenolate Mofetil vs Azathioprine for Remission Maintenance in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    Thomas F. Hiemstra;Michael Walsh;Alfred Mahr;Caroline O. Savage

Frequent Co-Authors

Andrew J. Vickers
Andrew J. Vickers Memorial Sloan Kettering Cancer Center
Peter T. Scardino
Peter T. Scardino Memorial Sloan Kettering Cancer Center
Hans Lilja
Hans Lilja Memorial Sloan Kettering Cancer Center
Charles D. Pusey
Charles D. Pusey Imperial College London
David Jayne
David Jayne University of Cambridge
James A. Eastham
James A. Eastham Memorial Sloan Kettering Cancer Center
Paul Russo
Paul Russo Memorial Sloan Kettering Cancer Center
Alan D. Salama
Alan D. Salama University College London
Raashid Luqmani
Raashid Luqmani University of Oxford
Anders Bjartell
Anders Bjartell Lund University

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