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Biology and Biochemistry

D-Index
52
Citations
9011
World Ranking
16747
National Ranking
6915

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Caroline C. Philpott is affiliated with the National Institutes of Health in the United States. Their research centers primarily on topics related to trace elements in health and iron metabolism, with additional focus on endoplasmic reticulum stress, hemoglobinopathies, and RNA biology. The scientist repeatedly contributes to fields within medicine as well as biochemistry, genetics, and molecular biology.

Their publication record includes work spanning several important subfields such as molecular biology, nutrition and dietetics, hematology, cell biology, and genetics. Their research topics cover:

  • Trace Elements in Health
  • Iron Metabolism and Disorders
  • Endoplasmic Reticulum Stress and Disease
  • Hemoglobinopathies and Related Disorders
  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer

Among their frequent co-authors are Olga Protchenko, Minoo Shakoury-Elizeh, Ethan Baratz, Shyamalagauri Jadhav, and Lorena Novoa-Aponte. These collaborations have appeared across various venues including Blood, Proceedings of the National Academy of Sciences, Cell Chemical Biology, Hepatology, and Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.

Representative recent papers authored or co-authored by Caroline C. Philpott include:

  • Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones (2020), Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis (2020), Cell Chemical Biology
  • Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis (2020), Hepatology
  • RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity (2020), Science Advances
  • The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential (2021), Proceedings of the National Academy of Sciences

Their work has been recognized by membership in professional organizations, including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • A Cytosolic Iron Chaperone That Delivers Iron to Ferritin

    Haifeng Shi;Krisztina Z. Bencze;Timothy L. Stemmler;Caroline C. Philpott

  • Iron uptake in fungi: a system for every source.

    Caroline C. Philpott

  • Response to Iron Deprivation in Saccharomyces cerevisiae

    Caroline C. Philpott;Olga Protchenko

  • Regulation of Cation Balance in Saccharomyces cerevisiae

    Martha S. Cyert;Caroline C. Philpott

  • A regulated RNA binding protein also possesses aconitase activity.

    Stamatina Kaptain;William E. Downey;Careen Tang;Caroline Philpott

  • Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

    D.A. Stoyanovsky;Y.Y. Tyurina;I. Shrivastava;I. Bahar

  • Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae.

    Minoo Shakoury-Elizeh;John Tiedeman;Jared Rashford;Tracey Ferea

  • Siderophore-iron uptake in Saccharomyces cerevisiae: Identification of ferrichrome and fusarinine transporters

    Cheol Won Yun;John S. Tiedeman;Robert E. Moore;Caroline C. Philpott

  • Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake.

    Cheol Won Yun;Tracy Ferea;Jared Rashford;Orly Ardon

  • Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2

    Anjali Nandal;Julio C. Ruiz;Poorna Subramanian;Sudipa Ghimire-Rijal

  • The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae.

    Cheol Won Yun;Matthew Bauler;Robert E. Moore;Phillip E. Klebba

  • Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin

    Sebastien Leidgens;Kimberley Z. Bullough;Haifeng Shi;Fengmin Li

  • Metabolic Response to Iron Deficiency in Saccharomyces cerevisiae

    Minoo Shakoury-Elizeh;Olga Protchenko;Alvin Berger;James Cox

  • Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis.

    Hülya Bayır;Hülya Bayır;Tamil S. Anthonymuthu;Tamil S. Anthonymuthu;Yulia Y. Tyurina;Sarju J. Patel

  • α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease.

    Tatiana K. Rostovtseva;Philip A. Gurnev;Olga Protchenko;David Paul Hoogerheide

  • Three cell wall mannoproteins facilitate the uptake of iron in Saccharomyces cerevisiae.

    Olga Protchenko;Tracy Ferea;Jared Rashford;John Tiedeman

  • The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.

    Caroline C. Philpott;Richard D. Klausner;Tracey A. Rouault

  • Differences in the RNA binding sites of iron regulatory proteins and potential target diversity

    Julea Butt;Hae Yeong Kim;James P. Basilion;Seth Cohen

  • Iron-dependent metabolic remodeling in S. cerevisiae.

    Jerry Kaplan;Diane McVey Ward;Robert J. Crisp;Caroline C. Philpott

  • PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

    Moon Suhn Ryu;Deliang Zhang;Olga Protchenko;Minoo Shakoury-Elizeh

Frequent Co-Authors

Tracey A. Rouault
Tracey A. Rouault National Institutes of Health
Valerian E. Kagan
Valerian E. Kagan University of Pittsburgh
James A. Wohlschlegel
James A. Wohlschlegel University of California, Los Angeles
Hülya Bayır
Hülya Bayır University of Pittsburgh
Ajay A. Vashisht
Ajay A. Vashisht University of California, Los Angeles
David Botstein
David Botstein Princeton University
Patrick O. Brown
Patrick O. Brown Stanford University
Zoltán Kutalik
Zoltán Kutalik University of Lausanne
Evan E. Eichler
Evan E. Eichler University of Washington

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