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Biology and Biochemistry

D-Index
77
Citations
32536
World Ranking
4688
National Ranking
2270

Overview

Brian L. West is affiliated with Daiichi Sankyo in the United States. Their research spans multiple disciplines within medicine and neuroscience, with primary focus areas including neurology and hematology. The scientist's work encompasses studies on neuroinflammation, neurodegeneration mechanisms, and leukemia treatments.

Their publication record includes research on topics such as neurogenesis, neuroplasticity mechanisms, acute myeloid leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, and musculoskeletal synovial abnormalities. These topics reflect a broad engagement with both neurological disease mechanisms and hematological disorders.

Frequent coauthors associated with their work include:

  • Henry H. Hsu
  • Paul Severson
  • Eszter Császár
  • Nikolett Lénárt
  • Csaba Cserép

Brian L. West has published extensively in several scientific journals, notably:

  • Journal of Neuroinflammation (2 publications)
  • Clinical Cancer Research (2 publications)
  • The Journal of Experimental Medicine (1 publication)
  • Glia (1 publication)
  • Blood Advances (1 publication)

Selected recent publications include:

  • "Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions" (2022), The Journal of Experimental Medicine
  • "Activated microglia drive demyelination via CSF1R signaling" (2021), Glia
  • "Mitigation of helium irradiation-induced brain injury by microglia depletion" (2020), Journal of Neuroinflammation
  • "A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia" (2020), Blood Advances
  • "Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice" (2020), Journal of Neuroinflammation

Their main fields of study are Medicine and Neuroscience, with subfields including:

  • Neurology
  • Hematology
  • Physiology
  • Genetics
  • Rheumatology

Brian L. West's contributions center around neuroinflammatory processes, neurological disease mechanisms, and hematological malignancies, as seen through both clinical studies and basic science research. This intersection of disciplines situates their work at the nexus of neurobiology and oncology research.

Best Publications

  • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma

    Gideon Bollag;Peter Hirth;James Tsai;Jiazhong Zhang

  • Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

    Monica Renee Pittman Elmore;Allison Rachel Najafi;Maya Allegra Koike;Nabil Nazih Dagher

  • Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

    David G. DeNardo;David G. DeNardo;Donal J. Brennan;Elton Rexhepaj;Brian Ruffell

  • A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

    Guy Cathala;Jean Francois Savouret;Bernardita Mendez;Brian L. West

  • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

    James Tsai;John T. Lee;Weiru Wang;Jiazhong Zhang

  • CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

    Yu Zhu;Brett L. Knolhoff;Melissa A. Meyer;Timothy M. Nywening

  • A structural role for hormone in the thyroid hormone receptor

    Richard L. Wagner;James W. Apriletti;Mary E. McGrath;Brian L. West

  • Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

    Jonathan B Mitchem;Donal J Brennan;Brett L Knolhoff;Brian A Belt

  • Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.

    Elizabeth Spangenberg;Paul L. Severson;Lindsay A. Hohsfield;Joshua Crapser

  • Germline KRAS mutations cause Noonan syndrome

    Suzanne Schubbert;Martin Zenker;Sara L . Rowe;Silke Böll

  • Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

    Elizabeth E. Spangenberg;Rafael J. Lee;Allison R. Najafi;Rachel A. Rice

  • Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors

    Weijun Feng;Ralff C. J. Ribeiro;Ralff C. J. Ribeiro;Richard L. Wagner;Richard L. Wagner;Hoa Nguyen;Hoa Nguyen

  • CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

    Jingying Xu;Jemima Escamilla;Stephen Mok;John David

  • Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.

    Gergely Szalay;Bernadett Martinecz;Nikolett Lénárt;Zsuzsanna Környei

  • Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

    William D Tap;Zev A Wainberg;Stephen P Anthony;Prabha N Ibrahim

  • Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

    Neil Romberg;Khatoun Al Moussawi;Carol Nelson-Williams;Amy L Stiegler

  • Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

    Nabil N. Dagher;Allison R. Najafi;Kara M. Neely Kayala;Monica R. P. Elmore

  • Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

    Nicholas Butowski;Howard Colman;John F. De Groot;Antonio M. Omuro

  • Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling.

    Salvatore J Coniglio;Eliseo Eugenin;Kostantin Dobrenis;E Richard Stanley

  • Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

    Debyani Chakravarty;Elmer Santos;Mabel M Ryder;Jeffrey A. Knauf

Frequent Co-Authors

John D. Baxter
John D. Baxter University of California, San Francisco
Robert J. Fletterick
Robert J. Fletterick University of California, San Francisco
Kim N. Green
Kim N. Green University of California, Irvine
Lisa M. Coussens
Lisa M. Coussens Oregon Health & Science University
Jeffrey A. Sosman
Jeffrey A. Sosman Northwestern University
Antoni Ribas
Antoni Ribas University of California, Los Angeles
Amit Verma
Amit Verma Albert Einstein College of Medicine
John M. Greally
John M. Greally Albert Einstein College of Medicine
Hope S. Rugo
Hope S. Rugo University of California, San Francisco
Patricia C. Babbitt
Patricia C. Babbitt University of California, San Francisco

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