D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 75 Citations 18,584 317 World Ranking 2633 National Ranking 972

Research.com Recognitions

Awards & Achievements

1971 - Paul Karrer Gold Medal, University of Zurich

1969 - Member of the National Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Organic chemistry
  • Biochemistry

Stereochemistry, Biochemistry, Enzyme, Organic chemistry and Hydroxylation are his primary areas of study. His work on Histrionicotoxins as part of general Stereochemistry study is frequently linked to Isoleucine, bridging the gap between disciplines. His Biochemistry study combines topics in areas such as Stimulation, Depolarization and Tetrodotoxin.

His biological study spans a wide range of topics, including Tryptophan, Amphetamine, Tyramine and Phenethylamine. As a part of the same scientific study, he usually deals with the Organic chemistry, concentrating on Metabolism and frequently concerns with Carcinogen, Toxicity, Lysergic acid diethylamide, Biotransformation and Excretion. The Hydroxylation study combines topics in areas such as Proline, Amino acid, Cis–trans isomerism and Normetanephrine.

His most cited work include:

  • Nonenzymatic Cleavage of Peptide Bonds: The Methionine Residues in Bovine Pancreatic Ribonuclease (744 citations)
  • Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds. (530 citations)
  • Hydroxylation-Induced Migration: The NIH Shift Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds (425 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Stereochemistry, Biochemistry, Organic chemistry, Medicinal chemistry and Enzyme. The concepts of his Stereochemistry study are interwoven with issues in Gramicidin A, Cleavage and Hydroxylation. His study in Biochemistry focuses on Proline and Tryptophan.

He most often published in these fields:

  • Stereochemistry (39.46%)
  • Biochemistry (17.77%)
  • Organic chemistry (15.36%)

What were the highlights of his more recent work (between 1973-2006)?

  • Stereochemistry (39.46%)
  • Acetylcholine receptor (4.82%)
  • Acetylcholine (4.22%)

In recent papers he was focusing on the following fields of study:

Bernhard Witkop focuses on Stereochemistry, Acetylcholine receptor, Acetylcholine, Organic chemistry and Membrane potential. Bernhard Witkop interconnects Optically active and Nicotinic acetylcholine receptor in the investigation of issues within Stereochemistry. His Acetylcholine receptor study also includes fields such as

  • Nicotinic agonist that connect with fields like Cholinergic,
  • Biophysics which intersects with area such as Sodium.

His Acetylcholine research focuses on Ion channel and how it relates to Electrophysiology. The study incorporates disciplines such as Photochemistry, Chemical synthesis and Biological activity in addition to Organic chemistry. His Biological activity course of study focuses on Molecular biology and Interferon and Structure–activity relationship.

Between 1973 and 2006, his most popular works were:

  • Gephyrotoxins, Histrionicotoxins and Pumiliotoxins from the Neotropical Frog Dendrobates histrionicus† (97 citations)
  • Anatoxin-a interactions with cholinergic synaptic molecules. (80 citations)
  • Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor. (79 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • Biochemistry

Bernhard Witkop spends much of his time researching Stereochemistry, Acetylcholine, Acetylcholine receptor, Membrane potential and Pharmacology. Bernhard Witkop has included themes like Nicotinic agonist and Cholinergic in his Stereochemistry study. In his research on the topic of Acetylcholine, Biophysics is strongly related with Ion channel.

His research investigates the connection between Acetylcholine receptor and topics such as Agonist that intersect with issues in Myocyte and Muscarinic acetylcholine receptor M4. His Membrane potential research integrates issues from Acetylcholine binding, Affinity chromatography and Dissociation constant. His work deals with themes such as In vitro metabolism, Toxicology and Methylation, which intersect with Pharmacology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Nonenzymatic Cleavage of Peptide Bonds: The Methionine Residues in Bovine Pancreatic Ribonuclease

Erhard Gross;Bernhard Witkop.
Journal of Biological Chemistry (1962)

1241 Citations

Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

J. W. Daly;D. M. Jerina;B. Witkop.
Cellular and Molecular Life Sciences (1972)

828 Citations

Hydroxylation-Induced Migration: The NIH Shift Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds

Gordon Guroff;Jean Renson;Sidney Udenfriend;John W. Daly.
Science (1967)

704 Citations

SELECTIVE CLEAVAGE OF THE METHIONYL PEPTIDE BONDS IN RIBONUCLEASE WITH CYANOGEN BROMIDE1

Erhard Gross;Bernhard Witkop.
Journal of the American Chemical Society (1961)

599 Citations

1,2-naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene.

Donald M. Jerina;John W. Daly;Bernhard Witkop;P. Zaltzman-Nirenberg.
Biochemistry (1970)

597 Citations

A Rapid Spectrophotometric Assay of Monoamine Oxidase Based on the Rate of Disappearance of Kynuramine

Herbert Weissbach;Thomas E. Smith;John W. Daly;Bernhard Witkop.
Journal of Biological Chemistry (1960)

493 Citations

GRAMICIDIN A. V. THE STRUCTURE OF VALINE- AND ISOLEUCINE-GRAMICIDIN A.

Reinhard Sarges;Bernhard Witkop.
Journal of the American Chemical Society (1965)

444 Citations

Role of the arene oxide-oxepin system in the metabolism of aromatic substrates: I. In vitro conversion of benzene oxide to a premercapturic acid and a dihydrodiol

D. Jerina;J. Daly;B. Witkop;P. Zaltzman-Nirenberg.
Archives of Biochemistry and Biophysics (1968)

313 Citations

The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. III. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes

Donald M. Jerina;John W. Daly;Bernhard Witkop;Perola Zaltzman-Nirenberg.
Journal of the American Chemical Society (1968)

302 Citations

Batrachotoxin: chemistry and pharmacology

E. X. Albuquerque;J. W. Daly;B. Witkop.
Science (1971)

274 Citations

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