World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
43
Citations
7311
World Ranking
7393
National Ranking
3190

Research.com Recognitions

  • 2007 - Hellman Fellow

Overview

Alexander F. Hoffman is affiliated with the National Institute on Drug Abuse in the United States. Their research focuses primarily on the fields of Neuroscience and Medicine, with significant contributions to Cellular and Molecular Neuroscience, Pharmacology, Molecular Biology, and Social Psychology. Hoffman's work addresses key topics such as Neurotransmitter Receptor Influence on Behavior, Neuroscience and Neuropharmacology Research, Cannabis and Cannabinoid Research, Neuroendocrine Regulation and Behavior, Advanced Neural Network Applications, Advanced Image and Video Retrieval Techniques, and Receptor Mechanisms and Signaling.

Frequent coauthors collaborating with Hoffman include Carl R. Lupica, Ehsan Saboori, Sudhakar Sah, Michael H. Baumann, and Eun-Kyung Hwang. Their collaborative efforts have been published across several notable venues.

Hoffman has published extensively in journals such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • arXiv (Cornell University)
  • Proceedings of the National Academy of Sciences
  • Neuropsychopharmacology
  • ACS Chemical Neuroscience

Selected recent papers authored or co-authored by Hoffman include:

  • "Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients," 2022, Proceedings of the National Academy of Sciences
  • "Positive Allosteric Modulation of the 5-HT1A Receptor by Indole-Based Synthetic Cannabinoids Abused by Humans," 2020, ACS Chemical Neuroscience
  • "Persistent binding at dopamine transporters determines sustained psychostimulant effects," 2023, Proceedings of the National Academy of Sciences
  • "Impairment of Synaptic Plasticity by Cannabis, Δ9-THC, and Synthetic Cannabinoids," 2020, Cold Spring Harbor Perspectives in Medicine
  • "Effects of Withdrawal from Cocaine Self-Administration on Rat Orbitofrontal Cortex Parvalbumin Neurons Expressing Cre recombinase: Sex-Dependent Changes in Neuronal Function and Unaltered Serotonin Signaling," 2021, eNeuro

Hoffman received the Hellman Fellow award in 2007.

Best Publications

  • Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo.

    Barry J. Hoffer;Alex Hoffman;Kate Bowenkamp;Peter Huettl

  • Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus

    Alexander F. Hoffman;Carl R. Lupica

  • Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products.

    Michael H Baumann;John S Partilla;Kurt R Lehner;Eric B Thorndike

  • Single rodent mesohabenular axons release glutamate and GABA

    David H Root;Carlos A Mejias-Aponte;Shiliang Zhang;Hui-Ling Wang

  • Glial Cell Line-Derived Neurotrophic Factor Supports Survival of Injured Midbrain Dopaminergic Neurons

    Kathryn E. Bowenkamp;Alexander F. Hoffman;Greg A. Gerhardt;Michael A. Henry

  • Marijuana and cannabinoid regulation of brain reward circuits.

    Carl R Lupica;Arthur C Riegel;Alexander F Hoffman

  • Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo

    John Hudson;Ann Charlotte Granholm;Greg A. Gerhardt;Michael A. Henry

  • Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons

    Shiliang Zhang;Jia Qi;Xueping Li;Hui-Ling Wang

  • Cocaine Drives Aversive Conditioning via Delayed Activation of Dopamine-Responsive Habenular and Midbrain Pathways

    Thomas C. Jhou;Cameron H. Good;Courtney S. Rowley;Sheng-ping Xu

  • Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure.

    Alexander F. Hoffman;Murat Oz;Tara Caulder;Carl R. Lupica

  • Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids.

    Alexander F. Hoffman;Carl R. Lupica

  • A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons.

    Jia Qi;Shiliang Zhang;Hui-Ling Wang;Huikun Wang

  • Contribution of the Hyperpolarization-Activated Current (I h) to Membrane Potential and GABA Release in Hippocampal Interneurons

    Carl R. Lupica;James A. Bell;Alexander F. Hoffman;Patricia L. Watson

  • Opposing actions of chronic Δ9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation

    Alexander F. Hoffman;Murat Oz;Ruiqin Yang;Aron H. Lichtman

  • Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.

    † Reeti Katoch-Rouse;Olga A. Pavlova;Tara Caulder;Alexander F. Hoffman

  • Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease

    Cameron H. Good;Alexander F. Hoffman;Barry J. Hoffer;Vladimir I. Chefer

  • Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors

    Alexander F. Hoffman;Nora Laaris;Masahito Kawamura;Susan A. Masino

  • Silent synapses in selectively activated nucleus accumbens neurons following cocaine sensitization

    Eisuke Koya;Fabio C Cruz;Robert Ator;Sam A Golden

  • Effects of recording media composition on the responses of Nafion-coated carbon fiber microelectrodes measured using high-speed chronoamperometry.

    Greg A Gerhardt;Alexander F Hoffman

  • Nogo receptor 1 regulates formation of lasting memories

    Alexandra Karlén;Tobias E. Karlsson;Anna Mattsson;Karin Lundströmer

  • Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear.

    A Asok;A Draper;A F Hoffman;J Schulkin

Frequent Co-Authors

Carl R. Lupica
Carl R. Lupica National Institute on Drug Abuse
Greg A. Gerhardt
Greg A. Gerhardt University of Kentucky
Barry J. Hoffer
Barry J. Hoffer Case Western Reserve University
Geoffrey Schoenbaum
Geoffrey Schoenbaum National Institutes of Health
Lars Olson
Lars Olson Karolinska Institute
Marisela Morales
Marisela Morales National Institute on Drug Abuse
Wayne A. Cass
Wayne A. Cass University of Kentucky
Zhiming Zhang
Zhiming Zhang University of Kentucky
Don M. Gash
Don M. Gash University of Kentucky
Nils-Göran Larsson
Nils-Göran Larsson Karolinska Institute

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Alexander F. Hoffman

Trending Scientists

Recently Published Articles