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Journal of Medicinal Chemistry
H-index 84

Journal of Medicinal Chemistry

0022-2623

Published by: American Chemical Society Publications

https://pubs.acs.org/journal/jmcmar

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Chemistry 53 814 1558 70

Additional Metrics

Number of Best Scientists*: 2243
Documents by Best Scientists*: 2778
Top 100 Ranked Scientists*: 73
SCIMAGO H-index: 314
SCIMAGO SJR: 1.801
Impact Factor: 6.8

Overview

Top Research Topics at Journal of Medicinal Chemistry?

The objective of the journal is to combine knowledge in the areas of Stereochemistry, Biochemistry, Structure–activity relationship, Pharmacology and Biological activity. It facilitates discussions on Stereochemistry that incorporate concepts from other fields like In vitro, Chemical synthesis, Enzyme inhibitor, Receptor and In vivo. The research on Chemical synthesis featured in it combines topics in other fields like Bicyclic molecule, Moiety, Molecular model and Carboxamide.

Agonist and Antagonist are some of the facets of Receptor tackled in Journal of Medicinal Chemistry. Discussions in the journal are anchored in the subject of Biochemistry and the similar topic of Cell culture. It focuses on Structure–activity relationship research which is adjacent to topics in Stereoisomerism.

The journal links adjacent topics like Pharmacology with Potency.

  • Stereochemistry (47.39%)
  • Biochemistry (23.79%)
  • Structure–activity relationship (18.44%)

What are the most cited papers published in the journal?

  • Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. (5330 citations)
  • Molecular properties that influence the oral bioavailability of drug candidates. (3556 citations)
  • Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein-Ligand Complexes (3484 citations)

Research areas of the most cited articles at Journal of Medicinal Chemistry:

The journal articles facilitate discussions on Stereochemistry, Biochemistry, Structure–activity relationship, Chemical synthesis and Enzyme inhibitor. The Stereochemistry research tackled in the published articles is interrelated with In vivo which concerns subjects like Pharmacology. The published papers explore topics in Structure–activity relationship which can be helpful for research in disciplines like Potency and Stereoisomerism.

What topics the last edition of the journal is best known for?

  • Enzyme
  • Organic chemistry
  • Pharmacology

The previous edition focused in particular on these issues:

Journal of Medicinal Chemistry mostly deals with topics like In vivo, Pharmacology, Cancer research, Biochemistry and In vitro. Topics in In vivo were tackled in line with various other fields like Cell culture, IC50, Small molecule, Cell biology and Structure–activity relationship. The Structure–activity relationship study featured in the journal draws connections with the study of Stereochemistry.

Aside from discussions in Pharmacology, the journal also deals with the subject of Receptor which intersects with Peptide disciplines. Topics in Cancer research explored in the journal were investigated in conjunction with research in Cancer cell, Cancer, Breast cancer, Apoptosis and Kinase. Enzyme is a major topic of Biochemistry research.

The most cited articles from the last journal are:

  • Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models. (24 citations)
  • U.S. FDA Approved Drugs from 2015-June 2020: A Perspective (23 citations)
  • Spirocyclic Scaffolds in Medicinal Chemistry. (20 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Journal of Medicinal Chemistry (based on the number of publications) are:

  • Ettore Novellino (208 papers) published 4 papers at the last edition the same number as at the previous edition,
  • Jan Balzarini (157 papers) absent at the last edition,
  • Erik De Clercq (148 papers) published 5 papers at the last edition, 2 more than at the previous edition,
  • Philip S. Portoghese (138 papers) absent at the last edition,
  • William A. Denny (133 papers) published 1 paper at the last edition the same number as at the previous edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Journal of Medicinal Chemistry (based on the number of publications) are:

  • National Institutes of Health (652 papers) published 16 papers at the last edition, 3 more than at the previous edition,
  • Pfizer (439 papers) published 6 papers at the last edition, 8 less than at the previous edition,
  • Merck & Co. (366 papers) published 10 papers at the last edition, 1 more than at the previous edition,
  • Bristol-Myers Squibb (327 papers) published 14 papers at the last edition, 3 more than at the previous edition,
  • University of Minnesota (320 papers) published 9 papers at the last edition, 2 less than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 6.80% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 15.76% were posted by at least one author from the top 10 institutions publishing in the journal. Another 9.29% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 15.88% of all publications and 59.06% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Top Publications

  • Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism.

    Zhaoping Xiong;Zhaoping Xiong;Dingyan Wang;Xiaohong Liu;Xiaohong Liu;Feisheng Zhong

    (2020)
    946 Citations
  • Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight

    Terence C. S. Ho;Alex H. Y. Chan;A. Ganesan

    (2020)
    693 Citations
  • Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.

    Benjamin M. Johnson;Yue-Zhong Shu;Xiaoliang Zhuo;Nicholas A. Meanwell

    (2020)
    662 Citations
  • Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.

    Murugaiah A. M. Subbaiah;Nicholas A. Meanwell

    (2021)
    608 Citations
  • Rings in Clinical Trials and Drugs: Present and Future

    Unknown

    (2022)
    448 Citations
  • COVID-19: Drug targets and potential treatments.

    Carmen Gil;Tiziana Ginex;Inés Maestro;Vanesa Nozal

    (2020)
    428 Citations
  • Transfer Learning for Drug Discovery

    Chenjing Cai;Shiwei Wang;Youjun Xu;Weilin Zhang

    (2020)
    346 Citations
  • Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

    Arun K Ghosh;Margherita Brindisi;Margherita Brindisi

    (2020)
    344 Citations
  • On the Promise of Photopharmacology Using Photoswitches: A Medicinal Chemist's Perspective

    Matthew J Fuchter

    (2020)
    302 Citations
  • Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

    B. Liu;R. E. L. Trout;G.-H. Chu;D. Mcgarry

    (2020)
    284 Citations

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Best Scientists Contributing to This Journal

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