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Biology and Biochemistry

D-Index
47
Citations
16663
World Ranking
18546
National Ranking
593

Overview

Massimo Sargiacomo is affiliated with the Istituto Superiore di Sanità in Italy, with a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their scholarly output includes a concentration on molecular biology and cancer research, alongside studies in infectious diseases, parasitology, and immunology and allergy.

Their scientific publications demonstrate a thematic emphasis on extracellular vesicles and disease mechanisms. These topics include:

  • Extracellular vesicles in disease
  • MicroRNA in disease regulation
  • Amoebic infections and treatments
  • Parasitic infections and diagnostics
  • Cell adhesion molecules research
  • RNA interference and gene delivery
  • Nanoplatforms for cancer theranostics

Massimo Sargiacomo's recent papers cover studies on extracellular vesicles, immunosuppression, metabolic labeling, cholesterol transport, and protein composition of vesicles, as follows:

  • "Exploiting Manipulated Small Extracellular Vesicles to Subvert Immunosuppression at the Tumor Microenvironment through Mannose Receptor/CD206 Targeting" (2020), International Journal of Molecular Sciences
  • "Metabolic labelling of a subpopulation of small extracellular vesicles using a fluorescent palmitic acid analogue" (2023), Journal of Extracellular Vesicles
  • "Inhibition of cholesterol transport impairs Cav-1 trafficking and small extracellular vesicles secretion, promoting amphisome formation in melanoma cells" (2022), Traffic
  • "Unveiling Cryptosporidium parvum sporozoite-derived extracellular vesicles: profiling, origin, and protein composition" (2024), Frontiers in Cellular and Infection Microbiology
  • "A Simple and Scalable Assay for Multiplexed Flow Cytometric Profiling of Surface Markers on Small Extracellular Vesicles" (2025), Cells

Frequent coauthors working alongside Massimo Sargiacomo include:

  • Massimo Sanchez
  • Maria Luisa Fiani
  • Zaira Boussadia
  • Lucia Bertuccini
  • Valeria Barreca

The research contributions appear in several scientific journals, reflecting their range across molecular biology and cell research:

  • Journal of Extracellular Vesicles
  • Frontiers in Cellular and Infection Microbiology
  • International Journal of Molecular Sciences
  • Traffic
  • Cells

This publication pattern underlines a multi-disciplinary approach, crossing boundaries between basic biochemical processes and applied medical research, with a specific focus on cellular mechanisms related to extracellular vesicles and disease regulation.

Best Publications

  • Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

    Isabella Parolini;Cristina Federici;Carla Raggi;Luana Lugini

  • Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains DETERGENT-FREE PURIFICATION OF CAVEOLAE MEMBRANES

    Kenneth S. Song;Shengwen Li;Takashi Okamoto;Lawrence A. Quilliam

  • Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

    M. Sargiacomo;M. Sudol;Zhaolan Tang;M. P. Lisanti

  • Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.

    Michael P. Lisanti;Philipp E. Scherer;Jolanta Vidugiriene;ZhaoLan Tang

  • Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

    Michael P. Lisanti;Philipp E. Scherer;ZhaoLan Tang;Massimo Sargiacomo

  • Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin

    Shengwen Li;Takashi Okamoto;Miyoung Chun;Massimo Sargiacomo

  • Interaction of a Receptor Tyrosine Kinase, EGF-R, with Caveolins: CAVEOLIN BINDING NEGATIVELY REGULATES TYROSINE AND SERINE/THREONINE KINASE ACTIVITIES *

    Jacques Couet;Massimo Sargiacomo;Michael P. Lisanti

  • Oligomeric structure of caveolin: implications for caveolae membrane organization.

    Massimo Sargiacomo;Philipp E. Scherer;ZhaoLan Tang;Eric Kübler

  • A glycophospholipid membrane anchor acts as an apical targeting signal in polarized epithelial cells.

    M P Lisanti;I W Caras;M A Davitz;E Rodriguez-Boulan

  • Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles

    Philipp E. Scherer;Michael P. Lisanti;Giulia Baldini;Giulia Baldini;Massimo Sargiacomo;Massimo Sargiacomo

  • Polarized apical distribution of glycosyl-phosphatidylinositol-anchored proteins in a renal epithelial cell line

    Michael P. Lisanti;Massimo Sargiacomo;Lutz Graeve;Alan R. Saltiel

  • Caveolin Isoforms Differ in Their N-terminal Protein Sequence and Subcellular Distribution. IDENTIFICATION AND EPITOPE MAPPING OF AN ISOFORM-SPECIFIC MONOCLONAL ANTIBODY PROBE

    Philipp E. Scherer;Zhao Lan Tang;Miyoung Chun;Massimo Sargiacomo

  • Integral and peripheral protein composition of the apical and basolateral membrane domains in MDCK cells.

    M Sargiacomo;M Lisanti;L Graeve;A Le Bivic

  • "Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor.

    Marco Gabbianelli;Massimo Sargiacomo;Elvira Pelosi;Ugo Testa

  • Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane RETENTION OF CAVEOLIN-2 AT THE LEVEL OF THE GOLGI COMPLEX

    Isabella Parolini;Isabella Parolini;Massimo Sargiacomo;Ferruccio Galbiati;Giovanni Rizzo

  • Caveolin-3 Directly Interacts with the C-terminal Tail of β-Dystroglycan IDENTIFICATION OF A CENTRAL WW-LIKE DOMAIN WITHIN CAVEOLIN FAMILY MEMBERS

    Federica Sotgia;Federica Sotgia;Jean Kyung Lee;Kallol Das;Mark Bedford

  • Caveolin forms a hetero-oligomeric protein complex that interacts with an apical GPI-linked protein: implications for the biogenesis of caveolae.

    M. P. Lisanti;Zhaolan Tang;M. Sargiacomo

  • Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation

    Marialuisa Lavitrano;Maria Laura Bacci;Monica Forni;Davide Lazzereschi

  • Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton-insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes.

    I Parolini;M Sargiacomo;MP Lisanti;C Peschle

  • Role of Cholesterol in Human Immunodeficiency Virus Type 1 Envelope Protein-Mediated Fusion with Host Cells

    Mathias Viard;Isabella Parolini;Massimo Sargiacomo;Katia Fecchi

Frequent Co-Authors

Michael P. Lisanti
Michael P. Lisanti University of Salford
Philipp E. Scherer
Philipp E. Scherer The University of Texas Southwestern Medical Center
Cesare Peschle
Cesare Peschle Istituto Superiore di Sanità
Ugo Testa
Ugo Testa Istituto Superiore di Sanità
Cesare Peschle
Cesare Peschle Istituto Superiore di Sanità
Enrique Rodriguez-Boulan
Enrique Rodriguez-Boulan Cornell University
Ferruccio Galbiati
Ferruccio Galbiati University of Pittsburgh
Maurizio Sorice
Maurizio Sorice Sapienza University of Rome
Maria Rosaria Torrisi
Maria Rosaria Torrisi Sapienza University of Rome
Mario Falchi
Mario Falchi King's College London

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