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Microbiology

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54
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10814
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3949
National Ranking
85

Overview

Leen Rigouts is affiliated with the Institute of Tropical Medicine Antwerp in Belgium. Their research primarily focuses on medicine, with significant contributions to the fields of infectious diseases, epidemiology, molecular biology, surgery, and molecular medicine. The core areas of their scientific investigation include tuberculosis research and epidemiology, Mycobacterium research and diagnosis, antibiotic resistance in bacteria, diagnosis and treatment of tuberculosis, infectious diseases and tuberculosis, genomics and phylogenetic studies, and Pneumocystis jirovecii pneumonia detection and treatment.

Their recent noteworthy publications include the following:

  • "A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region" (2020), published in Nature Communications
  • "Deep amplicon sequencing for culture-free prediction of susceptibility or resistance to 13 anti-tuberculous drugs" (2020), published in European Respiratory Journal
  • "Reconstituting the genus Mycobacterium" (2021), published in INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
  • "Bedaquiline resistance in patients with drug-resistant tuberculosis in Cape Town, South Africa: a retrospective longitudinal cohort study" (2023), published in The Lancet Microbe
  • "Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains" (2020), published in Journal of Clinical Microbiology

Frequent co-authors who have collaborated extensively with Rigouts include:

  • Bouke C. de Jong
  • Tom Decroo
  • Conor J. Meehan
  • Wim Mulders
  • Jean Claude Semuto Ngabonziza

Leen Rigouts has published multiple articles in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Antimicrobial Agents and Chemotherapy
  • European Respiratory Journal
  • Scientific Reports
  • The International Journal of Tuberculosis and Lung Disease

The scientist's body of work integrates interdisciplinary approaches to tackle questions related to tuberculosis and bacterial resistance, making use of molecular and genomic techniques. Rigouts' research contributions cover both clinical and epidemiological perspectives, often collaborating with experts across microbiology and infectious disease domains. The focus on drug resistance and molecular diagnostics aligns with global health priorities concerning tuberculosis control and treatment efficacy.

Best Publications

  • Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology

    Karine Brudey;Jeffrey R Driscoll;Leen Rigouts;Wolfgang M Prodinger

  • Molecular evidence to support a proposal to reserve the designation Mycobacterium avium subsp. avium for bird-type isolates and 'M. avium subsp. hominissuis' for the human/porcine type of M. avium.

    Wouter Mijs;Petra de Haas;Rudi Rossau;Tridia Van der Laan

  • Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues.

    Conor J. Meehan;Galo A. Goig;Thomas A. Kohl;Lennert Verboven

  • A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

    Paolo Miotto;Belay Tessema;Elisa Tagliani;Leonid Chindelevitch

  • Rifampin Drug Resistance Tests for Tuberculosis: Challenging the Gold Standard

    Armand Van Deun;Armand Van Deun;Kya J. M. Aung;Valentin Bola;Rossin Lebeke

  • Mycobacterium tuberculosis Strains with Highly Discordant Rifampin Susceptibility Test Results

    A. Van Deun;L. Barrera;I. Bastian;L. Fattorini

  • Rifampin Resistance Missed in Automated Liquid Culture System for Mycobacterium tuberculosis Isolates with Specific rpoB Mutations

    Leen Rigouts;Leen Rigouts;Mourad Gumusboga;Willem Bram de Rijk;Elie Nduwamahoro

  • High Level of Cross-Resistance between Kanamycin, Amikacin, and Capreomycin among Mycobacterium tuberculosis Isolates from Georgia and a Close Relation with Mutations in the rrs Gene

    Levan Jugheli;Nino Bzekalava;Pim de Rijk;Krista Fissette

  • Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones: results from a multicountry surveillance project

    Matteo Zignol;Anna S. Dean;Natavan Alikhanova;Sönke Andres

  • GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions.

    Maha R. Farhat;Luca Freschi;Roger Calderon;Thomas Ioerger

  • Mixed infection and clonal representativeness of a single sputum sample in tuberculosis patients from a penitentiary hospital in Georgia

    Isdore C Shamputa;Levan Jugheli;Levan Jugheli;Nikoloz Sadradze;Eve Willery

  • Unexpected high prevalence of resistance-associated Rv0678 variants in MDR-TB patients without documented prior use of clofazimine or bedaquiline.

    Cristina Villellas;Nele Coeck;Conor J. Meehan;Nacer Lounis

  • Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value.

    Maha R. Farhat;Razvan Sultana;Oleg Iartchouk;Sam Bozeman

  • Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial

    Unknown

  • Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study

    Matteo Zignol;Andrea Maurizio Cabibbe;Anna S. Dean;Philippe Glaziou

  • Addressing multidrug-resistant tuberculosis in penitentiary hospitals and in the general population of the former Soviet Union.

    F Portaels;L Rigouts;I Bastian

  • Newly developed primers for the detection of Mycobacterium avium subspecies paratuberculosis.

    Elke Vansnick;Pim de Rijk;Francis Vercammen;Dirk Geysen

  • European 1 : a globally important clonal complex of Mycobacterium bovis

    Noel H. Smith;Stefan Berg;James Dale;Adrian Allen

  • African 1, an epidemiologically important clonal complex of Mycobacterium bovis dominant in Mali, Nigeria, Cameroon, and Chad.

    Borna Müller;Markus Hilty;Stefan Berg;M. Carmen Garcia-Pelayo

  • Multidrug-resistant tuberculosis in prison inmates, Azerbaijan.

    Gaby E. Pfyffer;Anni Strässle;Tamara van Gorkum;Françoise Portaels

  • Genotypic and Phenotypic Heterogeneity among Mycobacterium tuberculosis Isolates from Pulmonary Tuberculosis Patients

    Isdore Chola Shamputa;Leen Rigouts;Lovet Achale Eyongeta;Nabil Abdullah El Aila

Frequent Co-Authors

Françoise Portaels
Françoise Portaels Institute of Tropical Medicine Antwerp
Sebastien Gagneux
Sebastien Gagneux University of Basel
Stefan Niemann
Stefan Niemann Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Ruth McNerney
Ruth McNerney University of Cape Town
Dick van Soolingen
Dick van Soolingen National Institute for Public Health and the Environment
Sven Hoffner
Sven Hoffner Karolinska Institute
Martin L. Hibberd
Martin L. Hibberd London School of Hygiene & Tropical Medicine
Taane G. Clark
Taane G. Clark London School of Hygiene & Tropical Medicine
Arnab Pain
Arnab Pain King Abdullah University of Science and Technology
Susana Campino
Susana Campino London School of Hygiene & Tropical Medicine

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